Erectile dysfunction: prevalence and relationship to depression, alcohol abuse and panic disorder

Okulate, G T; Oladokun, Olayinka; Dogunro, A.S

doi:10.1016/s0163-8343(03)00015-x

Cited by 50 publications

(48 citation statements)

References 20 publications

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“…A handful of studies [26][27][28] have documented the harmful effects of chronic alcohol consumption on sexual functioning but hardly any study found potential beneficial effects of alcohol on ED. We have demonstrated through meta-analysis the possible beneficial effects of alcohol on ED.…”

Section: Discussionmentioning

confidence: 99%

Alcohol consumption and erectile dysfunction: meta-analysis of population-based studies

et al. 2007

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Alcohol is long regarded as a risk factor for erectile dysfunction (ED), but epidemiological evidence has been equivocal. We aimed to investigate the ED risk associated with various levels of alcohol consumption by meta-analysis. We searched for population-based studies on ED through Medline, PubMed, PsychInfo, and scanned through reference lists. Eleven cross-sectional studies were included and analyzed with random effects model. We reviewed the results from one crosssectional study and two cohort studies. Regular alcohol consumption was negatively associated with ED (odds ratio (OR) ¼ 0.79; 99% confidence interval (CI), 0.67-0.92; Po0.001). Consumption of 8 or more drinks/week significantly reduced the risk of ED (OR ¼ 0.85; 99% CI, 0.73-0.99; P ¼ 0.007), but consumption of less alcohol (1-7 drinks/week) was not significant (OR ¼ 0.73; 99% CI, 0.44, 1.20; P ¼ 0.101). Begg's test and Egger's test detected no significant publication bias. Our estimates (in sensitivity analyses) were rendered nonsignificant when International Index of Erectile Function definition was used and when statistical adjustment was made only for age. Meta-analysis of crosssectional studies yielded a protective association of alcohol on ED, but the two cohort studies did not demonstrate any significant findings for alcohol consumption. More research is needed to confirm whether alcohol is protective or is unrelated to ED development.

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Section: Discussionmentioning

confidence: 99%

Alcohol consumption and erectile dysfunction: meta-analysis of population-based studies

et al. 2007

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“…23,24 However, in another study, ex-and current smokers are at greater risk of ED. 25 There is no association between alcohol abuse and ED, 26 but a slight association between alcohol consumption and risk of ED was observed in MMAS subjects. 17 In this study, we acknowledge that the impact of smoking and alcohol on ED is not strong.…”

Section: Discussionmentioning

confidence: 98%

Association among hypogonadism, quality of life and erectile dysfunction in middle-aged and aged male in Taiwan

Hwang

Tsai³

et al. 2006

Int J Impot Res

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The association between hypogonadism, quality of life (QoL), and erectile dysfunction (ED) among the middle-aged and aged male in Taiwan is evaluated. A total of 680 study subjects aged X40 years old were recruited from Northern (n ¼ 276), Middle (n ¼ 238), and Southern (n ¼ 202) Taiwan, respectively. ED was diagnosed by score of International Index of Erectile Function (IIEF-5). Taiwan version questionnaire for QoL includes domain 1 (physical domain), domain 2 (psychological domain), domain 3 (social relationship domain), and domain 4 (environmental domain) was used to measure QoL. Blood hormones, including FSH, LH, Prolactin, SHBG, total testosterone (TT), calculated free testosterone (cFT), and bioavailable testosterone (Bio-T), were determined. Logistic regression analysis was used to estimate crude and multivariate-adjusted odds ratio of risk factors and its 95% confidence interval. A significantly inverse association between concentration of serum cFT and Bio-T, and severity of ED was observed. Scores of QoL of Domain 1-4 were significantly decreased with the increament of severity of ED. Significant correlations were found between IIEF scores and four domains of QoL, respectively. After adjustment for age, cFT and Bio-T, study subjects with ED (IIEFp21) would have significantly high risk of low level of QoL in four domains. In conclusion, a significant association between low levels of serum calculated cFT, Bio-T, and severity of ED was found. In addition, abnormal erectile function significantly associated with low level of QoL in four domains.

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“…Because subjects who were visited at their place of residence did not answer the depression scale, we examined the effect of the consequent selection bias by comparing age difference between subjects included in the analysis and those excluded. Based on the IIEF-5 score of 18, the subjects were divided into the ED group (0-17) and the normal group (18)(19)(20)(21)(22)(23)(24)(25) 3 In addition, the odds ratio of ED according to depression level was obtained through logistic regression analysis. We calculated both the age-adjusted odds ratio, which adjusted only age, and the multivariate-adjusted odds ratio, which adjusted all ED-related factors.…”

Section: Discussionmentioning

confidence: 99%

“…The results of this study are consistent with the results of many previous cross-sectional studies. 2,9,12,[20][21][22][23][24] In the MMAS, a cross-sectional study (N ¼ 1265) conducted from 1986 to 1989 with randomly sampled men aged between 40 and 70 years who were aging normally and healthily, the odds ratio of moderate or completed ED with adjusting related factors was 1.8 (95% CI ¼ 1.21-2.73) in depressive subjects (16XCED-S (the Center for Epidemiological Study's Depression scale)) compared with non-depressive ones. 9 The authors formulated a model for understanding the complex and dynamic relation between depression and ED, which is based on the disablement process applying by Verbrugge and Jette.…”

Section: Discussionmentioning

confidence: 99%

Relationship between ED and depression among middle-aged and elderly men in Korea: Hallym aging study

et al. 2011

Int J Impot Res

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The baseline questionnaires included demographic and health history information. The age-adjusted prevalence of current depression by GDS (X18), of ED by IIEF-5 score (o18), and of concomitant ED and depression were 12.2%, 28.2% and 11.0%, respectively. GDS increased according to severity of ED, adjusted for age, marital status, education, smoking, alcohol, hypertension, regular exercise, total cholesterol level, fasting blood sugar, body mass index (Po0.001, by analysis of covariance). ED was strongly associated with depression symptoms after controlling for potential confounding factors using logistic regression. Compared with GDS o8, odds ratios and 95% confidence intervals for 12-17 GDS and 18 or more GDS were 3.38 (1.30-8.77) and 6.56 (2.18-19.81), respectively. ED is significantly associated with highly depressive symptoms, regardless of age, health habit or concomitant comorbidity. Our results demonstrate that multidisciplinary approaches are important for the successful treatment of ED.

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Erectile dysfunction: prevalence and relationship to depression, alcohol abuse and panic disorder

Cited by 50 publications

References 20 publications

Alcohol consumption and erectile dysfunction: meta-analysis of population-based studies

Alcohol consumption and erectile dysfunction: meta-analysis of population-based studies

Association among hypogonadism, quality of life and erectile dysfunction in middle-aged and aged male in Taiwan

Relationship between ED and depression among middle-aged and elderly men in Korea: Hallym aging study

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