1989
DOI: 10.1111/j.2042-7158.1989.tb06546.x
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Ergometrine and 5-hydroxytryptamine binding sites in rat brain and myometrium

Abstract: Functional studies suggest that ergometrine is a partial agonist involving 5-hydroxytryptamine (5-HT) receptors in rat uterus. Ergometrine displaced [3H]5-HT from specific binding sites in rat brain, but did not displace [3H]5-HT at functionally important concentrations in rat myometrium. These binding studies indicate that the agonist and antagonist actions of ergometrine in rat uterus arise from its initial interaction with binding sites other than those for 5-HT.

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“…5‐HT binding assays were conducted in vitro as described fully elsewhere 12,13 K D and B Max values for specific [ 3 H]5‐HT (27.9 Ci/mmol, DuPont NEN) binding in brain membranes were calculated from Scatchard plots using the computerized nonlinear fitting program, LIGAND 14 …”
Section: Methodsmentioning
confidence: 99%
“…5‐HT binding assays were conducted in vitro as described fully elsewhere 12,13 K D and B Max values for specific [ 3 H]5‐HT (27.9 Ci/mmol, DuPont NEN) binding in brain membranes were calculated from Scatchard plots using the computerized nonlinear fitting program, LIGAND 14 …”
Section: Methodsmentioning
confidence: 99%