Erosive and cariogenicity potential of pediatric drugs: study of physicochemical parameters

Xavier, Alidianne Fábia Cabral; Moura, Eline F F; Azevedo, Waldeneide Fernandes de; Vieira, Fernando Fernandes; Abreu, Mauro Henrique Nogueira Guimarães de; Cavalcanti, Alessandro Leite

doi:10.1186/1472-6831-13-71

Cited by 45 publications

(64 citation statements)

References 18 publications

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“…The use of continuous medication is not the only causal factor for the presence of dental caries [30]; however, considering that pediatric drugs have tooth demineralization potential, these individuals will present an increased risk of erosive lesions [34,35] and caries, since pediatric medicinal products have high concentration of sugars, high titratable acidity, pH below critical value and high viscosity [36].…”

Section: Discussionmentioning

confidence: 99%

Chronology of the First Deciduous Tooth Eruption in Brazilian Children with Microcephaly Associated with Zika Virus: A Longitudinal Study

Aguiar

Cavalcanti

Alencar

et al. 2018

Pesqui. bras. odontopediatria clín. integr.

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Objective: To analyze the chronology of first deciduous tooth eruption in children with microcephaly associated with presumed or confirmed Zika virus. Material and Methods: A longitudinal study was developed with 74 children of both sexes. Data on prematurity, gestational age (in weeks), anthropometric characteristics at birth [length (cm), weight (g) and cephalic perimeter (cm)] and dental eruption (chronological age and corrected age for prematurity in months) were collected and presented through descriptive statistics. Data was analyzed using the Statistical Package for Social Sciences. Results: The majority of children were female (54.1%) and 14.9% were born premature. The mean gestational age was 38.2 (± 1.9) weeks, while length, weight and cephalic perimeter at birth were 45.6 (± 3.1) cm, 2750 (± 526.6) and 30 (± 2.3) cm, respectively. The eruption of the first tooth occurred on average at 12.3 (± 3.0) months of chronological age and at 11.1 (± 2.3) months of corrected age. The first erupted teeth were the lower deciduous central incisors (82.4%). The mean age for dental eruption in males was 12.5 months (± 3.0) and in females 12.0 months (± 3.1) among full-term children. For premature infants, the mean corrected age of dental eruption was 11.5 months (± 3.4) for boys and 11 months (± 1.7) for girls. Conclusion: In this group of children with microcephaly, the first tooth to erupt was the lower central incisor around the first year of life. Girls had lower average eruption time when compared to boys in both chronological age and age corrected for prematurity.

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Section: Discussionmentioning

confidence: 99%

Chronology of the First Deciduous Tooth Eruption in Brazilian Children with Microcephaly Associated with Zika Virus: A Longitudinal Study

Aguiar

Cavalcanti

Alencar

et al. 2018

Pesqui. bras. odontopediatria clín. integr.

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“…Previous studies 1,4,8,11,14,22 evaluated various types of medications, taking into consideration their chemical components, pH, or titratable acidity. Some authors observed that Claritin ® had low endogenous pH, between 2.1 and 2.8, 8,22 and that Polaramine ® presented the highest pH value (6.0).…”

Section: 20mentioning

confidence: 99%

Do pediatric medicines induce topographic changes in dental enamel?

et al. 2016

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The purpose of the present study was to evaluate the effect of common pediatric liquid medicines on surface roughness and tooth structure loss and to evaluate the pH values of these medicines at room and cold temperatures in vitro. Eighty-four bovine enamel blocks were divided into seven groups (n = 12): G1-Aliviumand G7-Milli-Q water (negative control). The pH was determined and the samples were immersed in each treatment 3x/day for 5 min. 3D non-contact profilometry was used to determine surface roughness (linear Ra, volumetric Sa) and the Gap formed between treated and control areas in each block. Scanning electron microscopy (SEM) and energy dispersive spectrometry (EDS) were also performed. The majority of liquid medicines had pH ≤ 5.50. G1, G4, and G5 showed alterations in Ra when compared with G7 (p < 0.05). According to Sa and Gap results, only G5 was different from G7 (p < 0.05). Alteration in surface was more evident in G5 SEM images. EDS revealed high concentrations of carbon, oxygen, phosphorus, and calcium in all tested groups. Despite the low pH values of all evaluated medicines, only Alivium

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“…Extrinsic acid source is derived from the environment (acidic pH of pools, corrosive industrial gases), diet (acidic foods and drinks), medicines (ascorbic, acetyl salicylic acids, antihistamines) and use of illegal drugs [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Erosive Potential of Commercially Available Candies

Lazzaris¹,

Farias²,

Araújo³

et al. 2015

Pesqui. bras. odontopediatria clín. integr.

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Objective: To measure the acidity of commercially available candies. Material and Methods: Tic Tac ® candies with the following flavors were selected: mint, orange, extra-strong, cinnamon, strawberry, cherry/passion fruit, acquired in supermarkets. Candies were triturated and from the resulting powder, 3 samples of 5 grams were separated and dissolved in 10ml of doubly deionized water. This process has allowed reading pH in triplicate, measured with the aid of an in vitro combined potentiometer and electrode, previously gauged with pH 4 and 7 with standard solutions before reading. In candies with pH values under 5.5.pH, tritatable acidity was verified. Three 15-gram candy powder samples were separately dissolved in 30 ml of doubly deionized water. In this solution, aliquots of 100 μl 1N NaOH were added to reach pH 5.5. Mineral water was used as control. The results were submitted to Analysis of Variance (ANOVA). The comparisons of means were carried out by the Tukey test at 5% significance level (p<0.05). Results: Only orange (pH 2.17), cherry/passion fruit (pH 2,26) and strawberry flavors (pH 2.46) have shown pH values under the critical point for enamel dissolution, significantly diverging from control and the other flavors. The volume of 1N NaOH used to raise the pH to 5.5 ranged from 2,000 to 2,800 μl, and the strawberry flavor has presented the highest tritatable acidity, significantly differing from the others. Conclusion: Candies of orange, cherry/passion fruit and strawberry flavors presented erosive potential and their frequent consumption can contribute to the development of dental erosion.

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Erosive and cariogenicity potential of pediatric drugs: study of physicochemical parameters

Cited by 45 publications

References 18 publications

Chronology of the First Deciduous Tooth Eruption in Brazilian Children with Microcephaly Associated with Zika Virus: A Longitudinal Study

Chronology of the First Deciduous Tooth Eruption in Brazilian Children with Microcephaly Associated with Zika Virus: A Longitudinal Study

Do pediatric medicines induce topographic changes in dental enamel?

Erosive Potential of Commercially Available Candies

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