Erratum to: Calcium and oxidative stress mediate perillaldehyde-induced apoptosis in Candida albicans

Tian, Hui; Qu, Su; Wang, Yanzhen; Lu, Zhaoqun; Zhang, Man; Gan, Yeyun; Zhang, Peng; Tian, Jianhua

doi:10.1007/s00253-017-8217-5

Cited by 5 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The preliminary work done by our team has shown that PAE demonstrates significant antifungal activity against filamentous fungi such as Aspergillus flavus and Aspergillus niger (Tian et al, 2015, 2016). Recently, our group has also shown that PAE has a remarkable antifungal effect on C. albicans , with a minimum inhibitory concentration (MIC) of 0.4 μL/mL (Tian et al, 2017b). The team has also identified that the effect of PAE on C. albicans occurs through the mechanism of Ca 2+ and oxidative stress-mediated apoptosis (Tian et al, 2017a).…”

Section: Introductionmentioning

confidence: 99%

“…Recently, our group has also shown that PAE has a remarkable antifungal effect on C. albicans , with a minimum inhibitory concentration (MIC) of 0.4 μL/mL (Tian et al, 2017b). The team has also identified that the effect of PAE on C. albicans occurs through the mechanism of Ca 2+ and oxidative stress-mediated apoptosis (Tian et al, 2017a). However, no research reported in the literature has been designed to investigate the application of PAE to the treatment of C. albicans vaginitis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Perillaldehyde on Prophylaxis and Treatment of Vaginal Candidiasis in a Murine Model

Chen

Tian

et al. 2019

Front. Microbiol.

Self Cite

View full text Add to dashboard Cite

Vulvovaginal candidiasis is a common fungal infection afflicting women which is primarily caused by the yeast Candida albicans ( C. albicans ). It is imperative to introduce new drug classes to counter this threat due to the continuous emergence of drug-resistant cases in recent years. The purpose of this study was to clarify the in vivo antifungal activity of perillaldehyde (PAE) against C. albicans and to prove that PAE is a promising candidate for the control of vaginal candidiasis. An animal model of vaginitis was developed to demonstrate the therapeutic and preventive effects of PAE on vaginal candidiasis, and these were evaluated through fungal and histopathological examinations. In clarifying the mechanism of PAE, standard hematological test results indicated that white blood cells (WBC) were elevated abnormally in mice infected with C. albicans , whereas when the mice were treated with various concentrations of PAE, the number of WBC in the blood was reduced. Flow cytometry was used to detect the populations of neutrophils, macrophages and CD4 T cells in the vaginal tissue of the mice. PAE was found to reduce these immune cells, which all play a key role in the inflammatory response, and the related interleukin and pro-inflammatory cytokines, including IL-17, IL-22 and TNF-α. These were detected using ELISA. Finally, we detected the expression levels of E-cadherin in the PAE treatment mouse group and discovered that it had recovered to its normal levels, but in the infection mouse group, the E-cadherin expression was clearly suppressed by the presence of C. albicans . Our data demonstrated that PAE targets these cytokines and possesses the ability to fight the fungal infection while also reducing the levels of the inflammatory factors identified. Our results demonstrated that PAE has a significant preventative and therapeutic effect on vaginal candidiasis and is a potential candidate for the treatment of vaginal Candida infections.

show abstract