Eruptive Hamartomatous Clear-Cell Acanthomas

Abstract

This is a report on a 38-year-old female, suffering from over 100 solid papules arising on her legs, arms and trunk during the past 10 years. The histology shows the typical feature of clear-cell acanthoma (CCA). Extensive investigations did not reveal any extracutaneous abnormalities. This case is exceptional because of the high number of hamartomatous CCA which exceeds the maximal number of about 20 seen in multiple CCA so far and therefore is referred to as eruptive hamartomatous CCA.

Disseminated Eruptive Clear Cell Acanthoma With Spontaneous Regression: Further Evidence of an Inflammatory Origin?

“…This differs from previous reports, which state that the lesions usually appear slowly increasing in number over a period of 10 or more years. [1][2][3] It is also noteworthy that many of the lesions regressed, fact that has been previously reported. 16 Furthermore, the histopathological study suggested that the formation of clear cells rich in glycogen began close to nearby areas of intense spongiosis, which could support the existence of an underlying inflammatory condition.…”

“…5 Multiple disseminated eruptive CCA is a rare clinical variant that has been rarely reported. [1][2][3]6 It is characterized by the presence of more than 30 lesions from 1 to 10 mm in diameter that usually appear progressively, slowly increasing in number, over a period of years. 1 Lesions usually occur on the lower extremities of adult healthy women, although other locations, such as the trunk, wrist, and perineum have been described.…”

“…6 Differential diagnosis includes other eruptive dermatoses, such as psoriasis guttata, certain forms of parapsoriasis, sarcoidosis, lichen planus, or granuloma annulare. 3 Dermoscopy and videodermatoscopy may be useful for diagnosis of either solitary or multiple lesions, revealing a characteristic pattern consisting of partly homogeneous, symmetrically or bunch-like arranged, pinpoint-like capillaries that show a bush-like aspect at high magnification. 7,8 Cryotherapy and CO 2 laser have been successfully used to treat the lesions.…”

“…A rare eruptive form, with the presence of more than 30 lesions, has been described. [1][2][3] We report the case of a woman with multiple disseminated eruptive CCA. In contrast to previous reports, most lesions appeared in a short period of time (less than a month) and, what is more interesting is that some of them have regressed spontaneously.…”

Urachal duct remnant‐like umbilical clear cell acanthoma in an infant: An unusual presentation and pitfall in clinical practice

“…The exact origin of CCA remains unclear. The epidermis, 12,16,20,21 acrosyringium 22 and hair follicles 23 have been proposed as possible sites of origin. Landry et al.…”