Erworbene reaktiv perforierende Dermatose bei Psoriasis vulgaris - Therapeutisches Ansprechen auf Allopurinol -

Matthes, T; Trost, T. H.; Nilles, M.

doi:10.1055/s-2001-11490

Cited by 3 publications

(3 citation statements)

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“…2,6 Las lesiones pueden medir hasta 2 cm, algunas confluyen formando placas de hasta 8 cm de diámetro. 7,10,12 Kim y colaboradores 13 estudiaron 30 casos de CPRA y detectaron la presencia de prurito en 83.3% de los pacientes, así como fenómeno de Koebner en 31.8%, signos y síntomas útiles para realizar el diagnóstico.…”

Section: Cuadro Clínicounclassified

Colagenosis perforante reactiva adquirida

Ramos-Garibay¹,

Trejo-Acuña²,

Meza-Gaxiola³

2021

Revista Del Centro Dermatológico Pascua

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Caso clínico RESUMENLas dermatosis perforantes constituyen un grupo de enfermedades que se caracterizan clínicamente por la eliminación de diversos materiales cutáneos por vía transepidérmica. Se han descrito cuatro formas clásicas primarias en las que el material de eliminación representa el cuadro clínico distintivo. En las secundarias, la perforación y eliminación de las fibras del tejido conjuntivo constituyen un fenómeno que acompaña a otras dermatosis. La colagenosis perforante reactiva adquirida pertenece a este último grupo. La etiología no es clara, se le asocia con trastornos metabólicos y ciertas neoplasias. El prurito se considera un factor patogénico clave, ya que el rascado constante genera microtraumatismos en pacientes genéticamente predispuestos, provocando la degeneración focal de las fibras de colágeno. La topografía más frecuente es en el tronco (77%), seguido de las extremidades (64%), de las que compromete las zonas extensoras. Se manifiesta clínicamente con la presencia de pápulas eritematosas de aspecto umbilicado, con un tapón de queratina firmemente adherido en el centro. En la histopatología se observa eliminación transepidérmica de fibras de colágeno. Debido a que el tratamiento no está aún bien estandarizado, el manejo del prurito se considera una de las bases del mismo. Se recomienda tratar las enfermedades asociadas.Palabras clave: Dermatosis perforantes, colagenosis perforante reactiva adquirida, enfermedades por eliminación transepidérmica.

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Section: Cuadro Clínicounclassified

Colagenosis perforante reactiva adquirida

Ramos-Garibay¹,

Trejo-Acuña²,

Meza-Gaxiola³

2021

Revista Del Centro Dermatológico Pascua

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“…The clinical morphology of ARPD is characterized by umbilicated papules and plaques measuring 0.5–2.0 cm in diameter (Figures ). Lesions may coalesce to form larger lesions (Figure ), occasionally measuring up to 8 cm in diameter . Along with an erythematous, often only ridge‐like border, the clinical appearance is characterized by crusts which may be green‐brown or have an oyster‐shell‐like black appearance; depressed or flat‐elevated lesions are possible .…”

Section: Clinical Findingsmentioning

confidence: 99%

“…This results in a highly characteristic crater‐like structure, which remains if there are erosions after the crusts detach (Figure ). After the lesions heal, they leave atrophic, depressed, white or hyperpigmented scars . Predilection sites for ARPD include the trunk (Figure ), especially the shoulder girdle (Figure ), and the gluteal region as well as the extensor aspects on the upper and lower extremities .…”

Section: Clinical Findingsmentioning

confidence: 99%

Acquired reactive perforating dermatosis

Wagner

Sachse

2013

J Deutsche Derma Gesell

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Summary Acquired reactive perforating dermatosis is characterized by umbilicated erythematous papules and plaques with firmly adherent crusts. Histopathological examination shows a typical cup‐shaped ulceration in the epidermis containing cellular debris and collagen. There is transepidermal elimination of degenerated material with basophilic collagen bundles. The etiology and pathogenesis of acquired reactive perforating dermatosis are unclear. Metabolic disorders and malignancies are associated with this dermatosis. Associated pruritus is regarded as a key pathogenic factor. Constant scratching may cause a repetitive trauma to the skin. This pathogenesis may involve a genetic predisposition. The trauma may lead to degeneration of the collagen bundles. Treatment of acquired reactive perforating dermatosis follows a multimodal approach. Apart from the treating any underlying disease, treatment of pruritus is a major goal. Systemic steroids and retinoids, as well as UVB phototherapy are well‐established treatment options. Some patients may also benefit from oral allopurinol.

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The treatment of Kyrle's disease: a systematic review

Forouzandeh

Stratman

Yosipovitch

2020

Acad Dermatol Venereol

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Kyrle's disease (KD) is a cutaneous disease that develops in individuals with underlying systemic disease, particularly chronic renal failure and diabetes mellitus (DM), and is associated with a high burden of disease linked to itch. The intensely pruritic, hyperkeratotic papulonodular rash seen in KD dramatically impairs patients’ quality of life and increases their risk of mortality. Unfortunately, no guidelines or evidence‐based regimens have been specifically developed for KD, making the treatment of this disease particularly challenging for physicians. This article aims to provide the first comprehensive, up‐to‐date overview and analysis of treatment options employed for KD. A search of the PubMed/MEDLINE and Scopus databases was performed for articles regarding the treatment of KD, published in English between 1990 and 2019. Seventy‐three articles were identified, of which eighteen met the inclusion criteria. We discovered that a wide variety of treatment regimens for KD have been reported in the literature, including oral antibiotics, immunosuppressants, phototherapy, topical/systemic retinoids, topical keratolytics and various combination therapies, which include some of the aforementioned treatments, in conjunction with oral/topical/injectable steroids, emollients and/or antihistamines. The use of a combination regimen is the most commonly practiced therapeutic approach to KD. Topical corticosteroids and depot corticosteroid injections repeatedly appeared in many of the regimens encountered during our search. While no definitive recommendations can be made based on existing literature, this article provides physicians with a summative outline that can help guide management and be referenced when other treatment efforts fail. The increasing prevalence of renal disease, DM and other chronic diseases will inevitably lead to rising rates of KD in the upcoming years. While randomized controlled trials are greatly needed, novel antipruritic immunomodulatory drugs targeting specific interleukin receptors (IL‐4/13/31) and intracellular signalling (e.g. Janus kinase) pathways may have a potential role in the treatment of this disease.

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Erworbene reaktiv perforierende Dermatose bei Psoriasis vulgaris - Therapeutisches Ansprechen auf Allopurinol -

Cited by 3 publications

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Colagenosis perforante reactiva adquirida

Colagenosis perforante reactiva adquirida

Acquired reactive perforating dermatosis

The treatment of Kyrle's disease: a systematic review

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