Erythroid aplasia after halothane hepatitis

Jurgensen, J C; Abraham, Joseph; Hardy, William W.

doi:10.1007/bf02238120

Cited by 18 publications

(2 citation statements)

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“…The qualitative changes are infrequent and include atypical lymphocytes, macrocytosis, decreased red cell survival (13), and hemolytic anemia. Erythroid aplasia has been noted after halothane hepatitis (15).…”

Section: Discussionmentioning

confidence: 99%

Viral hepatitis and agranulocytosis

1973

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Transient hematopoietic aberrations are often found in association with viral hepatitis but are usually considered to be clinically insignificant. However, these changes are occasionally severe and sometimes fatal. Of the various hematologic manifestations which have been reported, agranulocytosis is very rare. Only two case reports are previously described in the literature (1, 2). We have described here two cases of viral hepatitis with agranulocytosis. The bone marrow examination in both these patients showed hypercellularity. CASE REPORTS Case One An 18-year-old whke male (C.R., WCGH 472170) was admitted to Wayne County General Hospital on October 27, 1971, because of jaundice of 2 weeks' duration. He was well until 2 weeks before the onset of jaundice, when he experienced anorexia, nausea, and progressively increasing weakness. With the onset of jaundice he also noticed pruritus. Bdth gradually increased in severity. On the night before admission, fever, profuse perspiration, sore throat, and dry cough were noticed. He admitted to heavy wine drinking which he stopped after the onset of the present illness. He denied oral or parenteral drug abuse, although he was closely associated with heroin addicts. Two of his friends were hospitalized because of hepatitis. He denied exposure to hepatotoxic drugs. Trimeprazine, 2.5 mg tablets, was prescribed by his family physician for nausea 4 weeks before hospitalization. He took only 2 or 3 tablets and discontinued the medication as he had no relief of symptoms. Physical examination disclosed a well-developed white

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Section: Discussionmentioning

confidence: 99%

Viral hepatitis and agranulocytosis

1973

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“…It is a documented complication of various kinds of hepatitis – viral [12, 13], or drug-induced [14], with both humoral [15, 16, 17, 18]and cell-mediated [19]suppression of erythropoiesis. However, it has not been documented in an ongoing HCV infection.…”

Section: Discussionmentioning

confidence: 99%

Pure Red Cell Aplasia Responsive to Interferon-α in a Patient with Hepatitis C Virus Infection

Davidovitz

Halpern²,

Vardi³

et al. 1998

Acta Haematol

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A 51-year-old man presented with severe anemia, mild splenomegaly and elevated serum aspartate aminotransferase and serum alanine aminotransferase levels. The bone marrow findings were consistent with pure red cell aplasia (PRCA) with a ‘maturation arrest’ at the level of pronormoblast. The patient has been transfusion-dependent for 8 months. Following diagnosis of chronic active hepatitis due to hepatitis C virus (HCV), therapy with interferon-α was initiated. Two weeks later, the hemoglobin level stabilized, and he has not required any transfusion ever since. In spite of ongoing HCV viremia, cessation of interferon therapy, and deterioration of the liver function tests, the patient, followed for 2 years, maintains a high-normal hemoglobin level. To the best of our knowledge, this is the first report of prolonged PRCA corrected by interferon-α therapy, with or without an ongoing HCV infection. We speculate that the ‘maturation arrest’ of the erythroid lineage seen in the bone marrow was the result of an immune mechanism, possibly induced by the HCV, and that the elimination of this mechanism, rather than the elimination of the HCV, provided the opportunity for regeneration of erythropoiesis.

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Transient Red Blood Cell Aplasia in Association With Viral Hepatitis

Sears¹

1975

Arch Intern Med

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Erythroid aplasia after halothane hepatitis

Cited by 18 publications

References 13 publications

Viral hepatitis and agranulocytosis

Viral hepatitis and agranulocytosis

Pure Red Cell Aplasia Responsive to Interferon-α in a Patient with Hepatitis C Virus Infection

Transient Red Blood Cell Aplasia in Association With Viral Hepatitis

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