ERYTHROPOIETIC RESPONSE TO CALORIGENIC HORMONES¹

Erythropoietm and the Kidney

“…In addition, however, estrogens decrease the number of hematopoietic stem cells and also the response of the marrow to EP [25,88,112,160], Several hormones influence EP production indirectly by increasing the amount of tissue oxygen consumption. Examples in this category are thyroxine [52], ACTH [39] and growth hormone. Still others such as angiotensin [45] cause an increase in EP production by decreas ing renal blood flow and aldosterone [174] which increases EP production by increasing oxygen consumption selectively by the kidney.…”

Severe Anemia in a Patient with Isolated Adrenocorticotropin Deficiency.

“…It has been well documented that hypophysectomy or adrenalectomy in experimental animals causes a mild anemia responsive to hormonal replacement therapy (1)(2)(3)(4)(5)(6). Corticosteroid deficiency in humans, such as Addison's disease and isolated adrenocorticotropic hormone (ACTH)deficiency, is known to cause a similar mild normocytic normochromic anemia (7).…”

The Central Nervous System in Regulation of Erythropoiesis

“…It has repeatedly been stated that the effect of the hormones on erythropoiesis is secondary to their control of oxygen consumption (6). Although this remains an important part of the control, re cent studies have changed this view considerably and have in dicated that the hormones have a more specific role in the regula tion of erythropoiesis.…”