¿Es la albúmina un predictor de gravedad y de mortalidad en pacientes con sepsis abdominal?

Abstract

mortalidad. Resultados: Se incluyeron 154 casos, 59 mujeres y 95 hombres. El principal órgano causante de sepsis abdominal fue el apéndice (41.6%). La mortalidad global fue del 14.3%. La presencia de fallas orgánicas fue del 35.1%. El valor medio de HDL se situó en 37.64 mg/dl (desviación estándar: ± 16.16). Los hallazgos, sometidos a verificación estadística mediante la prueba t de Student, mostraron significancia entre los casos con SOFA > 4 (p = 0.01) y Mannheim > 26 (p = 0.001), CONUT > 6 (p = 0.001), presencia de fallas orgánicas (p = 0.001) y mortalidad (p = 0.003). Conclusión: Los valores de HDL se relacionan con la gravedad, con el desarrollo de fallas orgánicas y con la mortalidad en la sepsis.

Lactate dehydrogenase to albumin ratio as a prognostic factor for patients with severe infection requiring intensive care

“…Hypoalbuminemia is a dose-dependent predictor of poor outcomes, including mortality, morbidity, and prolonged ICU and hospital stay. The association between hypoalbuminemia and poor clinical outcomes was independent of both nutritional status and inflammation [9–11] . Therefore, ALB and ALB-based ratios such as CRP/ALB, LAC/ALB, and BUN/ALB ratios have been evaluated as prognostic factors of infection and sepsis [13–15,19,20,29,31] …”

“…Thus some studies have mentioned that LDH level is a prognostic factor for infection [2–7] . Similarly, albumin (ALB) as a negative acute-phase proteins (APPs) can also serve as a biomarker for prognosis in sepsis patients because its levels tend to decrease with infection aggravation [8–11] . However, serum ALB levels can be affected by multiple conditions, including malnutrition and liver cirrhosis.…”

“…[2][3][4][5][6][7] Similarly, albumin (ALB) as a negative acute-phase proteins (APPs) can also serve as a biomarker for prognosis in sepsis patients because its levels tend to decrease with infection aggravation. [8][9][10][11] However, serum ALB levels can be affected by multiple conditions, including malnutrition and liver cirrhosis. For this reason, ALB has been used as a composite indicator such as blood urea nitrogen to albumin (BUN/ALB) ratio, lactate to albumin (LAC/ALB) ratio, C-reactive protein to albumin (CRP/ALB) ratio, and procalcitonin to ALB ratio rather than as a prognostic indicator alone.…”

Lactate dehydrogenase/albumin ratio as a prognostic factor in severe acute respiratory distress syndrome cases associated with COVID-19

“…[9] Serum albumin has been used as a prognostic factor for infections because it potentially decreases with infection exacerbation; it is low in patients with sepsis and has been reported to be a crucial factor affecting mortality and prognosis. [10–12]…”

“…[9] Serum albumin has been used as a prognostic factor for infections because it potentially decreases with infection exacerbation; it is low in patients with sepsis and has been reported to be a crucial factor affecting mortality and prognosis. [10][11][12] Hypoalbuminemia is also associated with chronic comorbid diseases or lifestyle factors such as smoking, alcoholism, and obesity. Therefore, there have been studies regarding albumin as a single prognostic indicator in infections and as a combination indicator of albumin-based ratios.…”