Esofagopatia chagásica na área endêmica de Bambuí - M.G., Brasil

Dias, João Carlos Pinto; Camacho, L; Silva, José Cândido da; Magalhães, João Soares; Krieger, Henrique

doi:10.1590/s0037-86821983000100007

Cited by 11 publications

(4 citation statements)

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“…The digestive form seems to be absent from certain countries, such as Panama and Venezuela, 1,2 whereas in central Brazil, 2-8.8% of patients have megaesophagus. [3][4][5][6] The pathogenesis of chagasic megaesophagus may be related to host characteristics as well as to different strains of the parasite Trypanosoma cruzi. 7 One of the most important factors that determines both symptoms and complications of this clinical form is the denervation of the smooth muscle of the esophagus 8,9 causing several morphological and motor changes, according to which megaesophagi are classified by Grades I-IV.…”

Section: Introductionmentioning

confidence: 99%

Relationship between Trypanosoma cruzi and human chagasic megaesophagus: blood and tissue parasitism.

Lages‐Silva

Crema²,

Ramı́rez³

et al. 2001

The American Journal of Tropical Medicine and Hygiene

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Abstract. The persistence of Trypanosoma cruzi in tissue and blood of 52 patients in the digestive form of chronic Chagas disease was studied. These patients had chagasic megaesophagus and underwent corrective surgery. Parasitologic (xenodiagnosis, hemoculture, or both), histopathologic (hematoxylin and eosin, and peroxidase-anti-peroxidase staining), and molecular (polymerase chain reaction [PCR] followed by slot-blot hybridization) tests were used in the analysis. The presence of T. cruzi, its genomic fragments, or its antigens could be detected in 98% (51 of 52) of the patients. The parasite was randomly identified in 76.9% of esophageal tissues and in 90.4% by PCR and in 73.1% by parasitologic methods from the blood. Fifty percent (26 of 52) of tissue samples had inflammation, 80.8% of which was associated with the parasite. Trypanosoma cruzi was also identified unassociated with inflammatory alterations. Higher tissue parasitism and intense inflammatory processes were observed in esophageal tissue from patients with Grade IV megaesophagus. These data demonstrate that in the digestive form of Chagas' disease, particularly in cases of megaesophagus, T. cruzi is frequently found, both in blood and tissues and may contribute to the pathogenic mechanisms involved.

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Section: Introductionmentioning

confidence: 99%

Relationship between Trypanosoma cruzi and human chagasic megaesophagus: blood and tissue parasitism.

Lages‐Silva

Crema²,

Ramı́rez³

et al. 2001

The American Journal of Tropical Medicine and Hygiene

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“…Não foi encontrada diferença significativa na freqüência de megaesôfago em relação ao sexo 8 . Contudo, outros autores mostraram que o megaesôfago é mais freqüente no sexo masculino 1 4 13 .…”

Section: Discussionunclassified

Estudo radiológico do esôfago de chagásicos, em 25 anos do Projeto Mambaí

Peñaranda-Carrillo

Castro

Rezende

et al. 2006

Rev. Soc. Bras. Med. Trop.

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Este trabalho relata os estudos do esôfago através da abreugrafia, de chagásicos do projeto Mambaí no período de 25 anos. Cada indivíduo realizou duas abreugrafias, em quatro períodos (1975-1976, 1980-1982, 1988-1991 e 1998-2000). A primeira abreugrafia foi realizada em posição obliqua anterior direita imediatamente após a ingestão de 75ml de sulfato de bário e a segunda um minuto após. Em todos os períodos foi utilizada a mesma metodologia, as abreugrafias foram lidas pelo mesmo pesquisador e os megaesôfagos foram classificadas em quatro grupos, segundo os critérios de Rezende e colaboradores. A prevalência de megaesôfago foi 5,2%; 5%; 18,6% e 13,9% em 1975-1976, 1980-1982, 1988-1991 e 1998-2000, respectivamente. A incidência de megaesôfago no período de 1975 a 2000 foi 11,5% (51/445). Durante 25 anos, 394 (84,2%) chagásicos permaneceram com o esofagograma normal, 11 (2,3%) diagnosticados com megaesôfago em 1975-1976, não progrediram, 61 (13%) que eram normais, duvidosos ou já tinham megaesôfago em 1975-1976, progrediram e 2 (0,4%) tiveram regressão do megaesôfago grupo I, diagnosticado em estudos anteriores.

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“…The sample consisted of 350 individuals from 180 families living in Bambui (State of Minas Gerais) in southeastern Brazil, an area endemic for Chagas' disease (for more details see Dias et al, 1983;Abreu et al, 1989;Krieger et al, 1992;Moro-Furlani and Krieger, 1992).…”

Section: Samplementioning

confidence: 99%

Evidence for biological inheritance of the eosinophil response to internal parasites in southeastern Brazil

et al. 1999

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One hundred and seventy-seven individuals belonging to 120 complete or incomplete nuclear families from Bambui, in the State of Minas Gerais, southeastern Brazil, were studied in order to examine causes of variation in the eosinophil rate among subjects infested by intestinal worms with an extra-digestive cycle. Segregation analysis without correction for skewness showed that the hypothesis of the presence of an additive major gene was consistent with the data, although a dominant, recessive, or a multifactorial hypothesis could not account properly for the observed significant familial aggregation. The most parsimonious correction for skewness showed similar results, but could not distinguish between dominant and recessive models, although co-dominance was rejected. Since these models assume that skewness was attributable to the commingling of two distributions, these results seem to agree with those for uncorrected data. These findings suggest that several genetically independent factors determine the resistance/susceptibility to helminth infestation mainly through their ability to influence the eosinophil response.
Uma amostra de 177 indivíduos pertencentes a 120 famílias nucleares, completas ou incompletas, de Bambui, Estado de Minas Gerais, sudeste do Brasil, foi estudada com o objetivo de apurar algumas das causas da variabilidade da taxa de eosinófilos em pessoas parasitadas por vermes intestinais com ciclo de vida extra-digestivo. A análise de segregação, aplicada aos dados sem correção para a assimetria, mostrou que a hipótese de um gene principal aditivo é consistente com os dados, enquanto que as hipóteses que supõem a ação de um gene dominante, de um gene recessivo ou ainda herança multifatorial não explicam, adequadamente, a significante agregação familial observada. A correção mais parcimoniosa para assimetria mostrou resultados semelhantes, mas não permitiu a distinção entre os modelos dominante e recessivo, embora permitisse a rejeição do modelo codominante. Considerando que esse modelo supõe ser a assimetria devida ao entrelaçamento de duas distribuições, esses resultados parecem concordar com aqueles obtidos quando os dados não foram corrigidos. Pode-se sugerir que o papel desempenhado por vários fatores genéticos independentes na resistência/suscetibilidade à infestação por helmintos seja determinado, principalmente, por suas capacidades de agir no estabelecimento de uma resposta eosinofílica

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Esofagopatia chagásica na área endêmica de Bambuí - M.G., Brasil

Abstract: Henrique Krieger4São

Cited by 11 publications

References 4 publications

Relationship between Trypanosoma cruzi and human chagasic megaesophagus: blood and tissue parasitism.

Relationship between Trypanosoma cruzi and human chagasic megaesophagus: blood and tissue parasitism.

Estudo radiológico do esôfago de chagásicos, em 25 anos do Projeto Mambaí

Evidence for biological inheritance of the eosinophil response to internal parasites in southeastern Brazil

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