2012
DOI: 10.1016/j.diabres.2012.01.036
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Esophageal body motility in people with diabetes: Comparison with non-diabetic healthy individuals

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Cited by 12 publications
(11 citation statements)
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“…As a potential limitation of the present study, examination of gastro-oesophageal functions was restricted to the use of high-resolution manometry and did not include radiographic measurements of oesophageal transit times or 24 h oesophageal pH measurements. Previous studies using these methods, conventional oesophageal manometry or radionuclide emptying have revealed faster oesophageal transit times, abnormal oesophageal contractions and reduced pressure measurements of the LES in patients with diabetes [24][25][26]. These conditions have also been assumed to predispose to an increased risk of oesophageal reflux and even Barrett's oesophagus in diabetic patients [31,32].…”
Section: Discussionmentioning
confidence: 99%
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“…As a potential limitation of the present study, examination of gastro-oesophageal functions was restricted to the use of high-resolution manometry and did not include radiographic measurements of oesophageal transit times or 24 h oesophageal pH measurements. Previous studies using these methods, conventional oesophageal manometry or radionuclide emptying have revealed faster oesophageal transit times, abnormal oesophageal contractions and reduced pressure measurements of the LES in patients with diabetes [24][25][26]. These conditions have also been assumed to predispose to an increased risk of oesophageal reflux and even Barrett's oesophagus in diabetic patients [31,32].…”
Section: Discussionmentioning
confidence: 99%
“…Oesophageal motility has been less well studied in patients with type 2 diabetes. The available studies have demonstrated normal oesophageal motility, delayed oesophageal transit times and reduced pressure of the lower oesophageal sphincter (LES) [22,[24][25][26]. However, most of these studies have been performed using conventional manometry catheters, which do not allow for continuous pressure monitoring throughout the oesophagus.…”
Section: Introductionmentioning
confidence: 99%
“…DM-induced changes Histology [16][17][18][58][59][60][61][62][63] Increased wall thickness and wall area, muscle hypertrophy, increased collagen fraction in the mucosa-submucosa layer, eosinophilic bodies, upregulated expressions of AGE and RAGE, axonal changes in the extrinsic and intrinsic parasympathetic fibers, degeneration of large myelinated vagal nerve fibers Passive biomechanical properties [16][17][18]32,62,68,73 Increased stiffness of intact wall in all directions, increased circumferential stiffness of mucosa-submucosa layer, decreased opening angle and residual strains, reduced longitudinal shortening and reduced radial stretch during distension Active biomechanical properties (motility) 3,6,[68][69][70][105][106][107][108][109][110][111][112][113][114][115][116][117][118][119][120] Decreased lower esophageal sphincter tone; increased upper esophageal sphincter tone; decreased esophageal transit; decreased frequency of peristaltic contractions after swallowing; decreased amplitude and velocity of esophageal body contractions; low esophageal peristaltic velocity; increased number of spontaneous and nonpropagating contractions, multipeaked contractions; distension-induced hyperreactivity and impaired coordination of the contractions; impaired relaxation and decreased LES pressure amplitude Sensitivity 13,19,…”
Section: Parametersmentioning
confidence: 99%
“…In a study comparing esophageal manometry of healthy individuals with that of diabetic patients, mechanisms of dysmotility observed included: (i) a decrease in effective peristalsis; (ii) a decrease in velocity and duration of peristaltic waves, especially in the distal esophagus; (iii) lower LES pressure; and (iv) an increase in multipeaked contractions. [30][31][32]…”
Section: Esophageal Dysmotility In Diabeticsmentioning
confidence: 99%
“…Obesity, defined as a BMI >30 kg/m 2 , can decrease life expectancy and increase the risk of developing diabetes 27 Acute changes in glucose can slow gastric emptying De Boer et al 28 Acute hyperglycemia impairs esophageal peristalsis, reduces LES pressure, delays gastric emptying, slows intestinal transit, and reduces gallbladder contraction Bodi et al 29 Diabetics may experience gut-specific capillary damage that affects the myenteric plexus Esophageal dysmotility Kinekawa et al 30 GI reflux and esophageal motility worsen with long duration of diabetes Jorge et al 31 Diabetics experience changes in patterns of esophageal waves Ahmed and Vohra 32 Poor relaxation of LES and slow propulsive velocity were noted in diabetics Kinekawa et al 30 Esophageal motility disorder and abnormal acid reflux related to diabetic motor neuropathy Gastroparesis Fass et al 33 Multifactorial relationship between GERD and gastroparesis involves increased gastric volume, GE pressure gradient, and potentially provoked tLESr Obesity Hirata et al 34 Coexistence of metabolic syndrome and low adiponectin associated with higher prevalence of GERD Hormonal changes Kawahara et al 35 Rikkunshito may increase plasma ghrelin; used for GERD treatment in Japan Rubenstein et al 36 Ghrelin may have protective effect against GERD Nakamone et al 37 Hypomotilinenemia observed in diabetics; gastric emptying highly correlated with fasting plasma motilin levels GE, gastroesophageal; GERD, gastroesophageal reflux disease; GI, gastrointestinal; LES, lower esophageal sphincter; tLESr, transient LES relaxation.…”
Section: Metabolic Syndrome and Obesitymentioning
confidence: 99%