Esophageal lichen planus

Bobadilla, Jaime Fernández de; Hulst, R. W. M. Van Der; Kate, F. J. W. Ten; Tytgat, G. N. J.

doi:10.1016/s0016-5107(99)70238-5

Cited by 38 publications

(20 citation statements)

References 21 publications

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“…A diagnosis of lichenoid oesophagitis was finally considered, based on the following evidence: first, the patient had, histologically confirmed oral lichen planus. Second, he presented with symptoms of dysphagia, odynophagia and sudden weight loss, and barium swallow as well as endoscopie examination revealed a stricture in the upper oesophagus, which corresponded to the previously described cases of lichenoid oesophagitis (8,9), even if histological findings were non-specific and resembled those of chronic mucosal inflammation. Third, poor response to proton pump inhibitors and good response to the treatment with systemic corticosteroid supported the autoimmunity aspects of the disorder.…”

Section: Discussionmentioning

confidence: 53%

Oral and Esophageal Lichen Planus following Radiotherapy of Nasopharyngeal Carcinoma

Wang¹,

Chen²,

Wang³

et al. 2011

Acta Derm Venerol

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Section: Discussionmentioning

confidence: 53%

Oral and Esophageal Lichen Planus following Radiotherapy of Nasopharyngeal Carcinoma

Wang¹,

Chen²,

Wang³

et al. 2011

Acta Derm Venerol

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“…Unfortunately, relapse can be expected in 85% when the treatment dose is reduced or withdrawn. Oral cyclosporine has been used successfully [4], but this did not help our patient. Topical tacrolimus has been used for oral lichen planus and in these patients an improvement of esophageal symptoms was noted and the frequency of dilatations for the known esophageal stricture was reduced [5].…”

Section: Discussionmentioning

confidence: 80%

Esophageal Lichen Planus: Case Report and Literature Review

Westbrook

Riley

2008

Dysphagia

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Lichen planus is an inflammatory mucocutaneous disorder that typically affects the flexor skin surfaces, mucous membranes, and genitalia. We describe a case of severe esophageal lichen planus associated with typical mucocutaneous manifestations and discuss the presentation, diagnosis, and difficulties encountered in treatment. The published literature is reviewed and treatment strategies described.

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“…Different systemic therapies are described. Systemic corticosteroids are supposed to be most effective as well as retinoids, cyclosporine, azathioprine, tacrolimus, rituximab and griseofulvin or intralesional corticosteroids [71,72,76,77,78,79,80,81,82,83,84,85,86]. …”

Section: Discussionmentioning

confidence: 99%

Oral, Esophageal and Cutaneous Lichen Ruber Planus Controlled with Alitretinoin: Case Report and Review of the Literature

Kolios¹,

Maggio²,

Gubler

et al. 2013

Dermatology

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Background: Therapy-resistant lichen planus (LP) can be a challenging condition for dermatologists. There are some case reports about successful treatments with alitretinoin of cutaneous and oral, but not of esophageal LP. Objective: We present the unique case of a patient with cutaneous, oral and esophageal LP which was refractory to classical treatment options (topical clobetasol propionate and pimecrolimus, intramuscular triamcinolone acetonide); because of systemic side effects the patient did not tolerate systemic acitretin dosed up to 25 mg daily. Methods: Oral alitretinoin was used at a dose of 30 mg daily. Results: Both oral and skin changes as well as dysphagia completely resolved within 4 weeks without any severe side effects and the drug was used for 6 months. No papules, intraoral striae or dysphagia recurred during the 6 months of treatment. After 4 months the patient relapsed with mucosal patches so that a second cycle was initiated for 6 months where oral LP lesions resolved after 4 weeks also (with sporadic mild headache). Conclusion: Further studies are needed to better understand the impact of alitretinoin in LP. Our observation suggests alitretinoin as a new, well-tolerated treatment option for esophageal LP after failed response to conventional treatments.

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Esophageal lichen planus

Cited by 38 publications

References 21 publications

Oral and Esophageal Lichen Planus following Radiotherapy of Nasopharyngeal Carcinoma

Oral and Esophageal Lichen Planus following Radiotherapy of Nasopharyngeal Carcinoma

Esophageal Lichen Planus: Case Report and Literature Review

Oral, Esophageal and Cutaneous Lichen Ruber Planus Controlled with Alitretinoin: Case Report and Review of the Literature

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