Esophageal Mucoepidermoid Carcinoma: A Review of 58 Cases

Abstract

BackgroundEsophageal mucoepidermoid carcinoma (EMEC) is a rare disease. The biological behavior and treatment of this malignancy are not well established.MethodsData from 58 patients with EMEC who underwent esophagectomy were retrospectively analyzed and compared with 5028 patients with esophageal squamous cell carcinoma (ESCC). Kaplan–Meier and multivariate Cox regression analyses were conducted to investigate the association between clinicopathological factors and survival.ResultsThe study cohort included 36 males and 22 females with a median age of 59 years (range, 40-78 years). Of the 47 patients who underwent preoperative esophagoscopic biopsy, only 1 patient was diagnosed with EMEC. EMEC was more often found in female patients (39.7% versus 25.8%, P=0.036) and patients with EMEC had a significantly lower rate of lymph node metastasis (25.0% versus 49.4%, P<0.001) than patients with ESCC. After 1:1 propensity score matching, the 5-year overall survival rate of 55.2% for patients with EMEC was similar to that of 61.9% for patients with ESCC (P=0.399).ConclusionsEMEC is a rare disease that more often affects females and these patients has less lymph node metastasis than patients with ESCC. Preoperative esophagoscopic biopsy has difficulty obtaining an accurate pathological diagnosis for EMEC patients. The prognosis for EMEC is similar to that for ESCC.

Clinico-pathological study of esophageal mucoepidermoid carcinoma: a 10-year survival from a single center

“…However, some scholars argue that MECE might originate from squamous epithelium, considering its extension into and infiltration of squamous tissue, predilection for certain sites, close association with dysplastic epithelial areas, and prognosis similar to squamous cell carcinoma [ 10 ]. As reported by Ozawa [ 5 ] and Chen [ 3 ], who noted a 0% accuracy rate for preoperative endoscopic diagnosis of MECE, Wang [ 11 ] observed that in a study of 47 patients, only one was diagnosed with MECE preoperatively via endoscopy, while the others were predominantly misdiagnosed as squamous cell carcinoma. In our series, the preoperative endoscopic diagnosis accuracy was only 6.3% (3/48), with MECE more frequently misdiagnosed as squamous carcinoma than adenocarcinoma (28 cases vs. 8 cases).…”

“…A literature review by Kumagai [ 14 ] of multiple studies from different hospitals and countries revealed a lymph node metastasis rate of 48.9% (45/92) in 92 MECE patients. Chen [ 3 ] and Wang [ 11 ] reported lymph node metastasis rates of 22.3% and 25.0%, respectively, significantly lower than the 49.4% in ESCC patients ( P < 0.001). Our study showed a lymph node metastasis rate of 35.4% (17/48) in MECE patients, which did not significantly differ from that in ESCC (45.5%, P = 0.165) but was higher than in EAC (21.4%, P = 0.034).…”

“…However, more recent studies have shown different results. Wang [ 11 ] and colleagues conducted a propensity score-matched analysis comparing surgically resected MECE with esophageal squamous carcinoma, revealing that the 5-year overall survival rate for MECE patients (58 cases) was 55.2%, similar to 61.9% in ESCC patients ( P = 0.399). In our data, the 5-year OS for MECE was 39.2%, showing no statistical difference with matched ESCC patients (54.5%, P = 0.119), aligning with Wang et al‘s findings.…”

Primary omental smooth muscle tumor in an adult male: a diagnostic dilemma for leiomyoma: a case report

“…The following types of tumors should be considered: gastrointestinal stromal tumor (GIST), solitary fibrous tumor (SFT), schwannoma, perivascular epithelioid cell tumor (PEComa), and a sclerosing variant of well-differentiated liposarcoma. Extra-GISTs are rare, but several cases have been reported [ 32 – 36 ]. Tumors in the greater omentum are frequently diagnosed as GIST [ 34 ].…”