Essential Oil Extracted from <i>Cymbopogon citronella</i> Leaves by Supercritical Carbon Dioxide: Antioxidant and Antimicrobial Activities

Wu, Hong; Li, Jilie; Jia, Yuan; Xiao, Zhihong; Li, Peiwang; Xie, Yingxin; Zhang, Aihua; Liu, Rukuan; Ren, Zewen; Zhao, Mengrui; Zeng, Chaozhen; Li, Changzhu

doi:10.1155/2019/8192439

Cited by 36 publications

(20 citation statements)

References 24 publications

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“…Wu et al have shown that high doses of substances known to have antioxidant property tend to have pro-oxidant activities. 26 In order to further investigate the apoptotic pathways LG may utilize to induce apoptosis, we conducted experiments to see whether inhibition of certain pathways would reduce cell death with the respective treatments. Interestingly, the addition of n-acetyl cysteine (NAC; an antioxidant agent) and Z-VAD-FMK (an irreversible pan-caspase inhibitor) did not inhibit apoptosis in LG-treated cells (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Lemongrass Extract Possesses Potent Anticancer Activity Against Human Colon Cancers, Inhibits Tumorigenesis, Enhances Efficacy of FOLFOX, and Reduces Its Adverse Effects

et al. 2019

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Current chemotherapeutics for metastatic colorectal cancers have limited success and are extremely toxic due to nonselective targeting. Some natural extracts have been traditionally taken and have shown anticancer activity. These extracts have multiple phytochemicals that can target different pathways selectively in cancer cells. We have shown previously that lemongrass (Cymbopogon citratus) extract is effective at inducing cell death in human lymphomas. However, the efficacy of lemongrass extract on human colorectal cancer has not been investigated. Furthermore, its interactions with current chemotherapies for colon cancer is unknown. In this article, we report the anticancer effects of ethanolic lemongrass extract in colorectal cancer models, and importantly, its interactions with FOLFOX and Taxol. Lemongrass extract induced apoptosis in colon cancer cells in a time and dose-dependent manner without harming healthy cells in vitro. Oral administration of lemongrass extract was well tolerated and effective at inhibiting colon cancer xenograft growth in mice. It enhanced the anticancer efficacy of FOLFOX and, interestingly, inhibited FOLFOX-related weight loss in animals given the combination treatment. Furthermore, feeding lemongrass extract to APCmin/+ transgenic mice led to the reduction of intestinal tumors, indicating its preventative potential. Therefore, this natural extract has potential to be developed as a supplemental treatment for colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Lemongrass Extract Possesses Potent Anticancer Activity Against Human Colon Cancers, Inhibits Tumorigenesis, Enhances Efficacy of FOLFOX, and Reduces Its Adverse Effects

et al. 2019

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“…Lemongrass essential oil may be extracted by many different methods like solvent extraction, steam distillation, hydrodistillation (HD), microwave-assisted hydrodistillation (MAHD), and supercritical uid extraction (SFE) with CO 2 . A number of studies have proved that the quality of essential oils depends mainly on its constituents, which is signi cantly in uenced by the extraction techniques [Desai & Parikh, 2015;Schaneberg & Khan, 2002;Wu et al, 2019]. Moreover, methods involving heating may induce thermal degradation or hydrolysis of fragile constituents.…”

Section: Extraction Of Lemongrass Essential Oilmentioning

confidence: 99%

Lemongrass (Cymbopogon citratus) Essential Oil: Extraction, Composition, Bioactivity and Uses for Food Preservation – a Review

Majewska¹,

Kozłowska²,

Gruczyńska–Sękowska³

et al. 2019

Pol. J. Food Nutr. Sci.

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, and the others in South Asia. Cymbopogon exuosus and Cymbopogon citratus represent the two major species vastly cultivated for their essential oils in different regions of the world. C. citratus is known by numerous international common names, such as West Indian lemon grass or lemon grass (English), citronelle or verveine des indes (French), hierba limon or zacate de limón (Spanish), xiang mao (Chinese), capimcidrao or capim-santo (Portuguese), and locally there are identi ed more than 28 indigenous names from different countries of the world. The genus Cymbopogon has been reviewed comprehensively in several articles [Avoseh et al., 2015; Haque et al., 2018]. C. citratus is an aromatic, evergreen, clump-forming, perennial grass producing numerous stiff stems arising from a short rhizomatous rootstock, and growing around 1.5 m tall. It rarely produces owers. The leaves are blue-green in colour, at, erect, linear in shape and give off a characteristic lemon avour when they are crushed. C. citratus is considered to have its origin in Malaysia, nowadays it is widely cultivated in the Central and South America and parts of Africa, Southeast Asia, and the Indian Ocean Islands, both on a commercial scale and in gardens especially in the South

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“…Studies have shown that the main commercial repellents are related to the repellency by the olfactory system of Ae. aegypti , such as DEET, [29] Icaridin, [12] and Citronellol Oil [30] …”

Section: Resultsmentioning

confidence: 99%

Identification of Bioactive Compounds against Aedes aegypti (Diptera: Culicidae) by Bioassays and in Silico Assays

Brito

Oliveira

Silva

et al. 2021

Chemistry & Biodiversity

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Most of the hematophagous insects act as disease vectors, including Aedes aegypti, responsible for transmitting some of the most critical arboviruses globally, such as Dengue. The use of repellents based on natural products is a promising alternative for personal protection compared to industrial chemical repellents. In this study, the repellent effect of essential oils extracted from Lippia thymoides, Lippia alba, Cymbopogon winterianus, and Eucalyptus globulus leaves was evaluated. Essential oils used showed repellent activity against Ae. aegypti in laboratory bioassays, obtaining protection rates above 70 % from 3.75 mg/mL and higher concentration for all analyzed oils. GC/MS identified 57 constituents, which were used in the ligand‐based pharmacophore model to expose compounds with requirements for repellents that modulate mosquitoes behavior through odorant‐binding protein 1 Ae. aegypti. Ligand‐based pharmacophore model approach results suggested that repellent activity from C. winterianus, L. alba, and L. thymoides essential oils’ metabolites is related to Citronelal (QFIT=26.77), Citronelol (QFIT=11.29), Citronelol acetate (QFIT=52.22) and Geranil acetate (QFIT=10.28) with synergistic or individual activity. E. globulus essential oil's repellent activity is associated with Ledol (0.94 %; QFIT=41.95). Molecular docking was applied to understand the binding mode and affinity of the essential oils’ data set at the protein binding site. According to molecular docking, Citronelol (ChemPLP=60.98) and geranyl acetate (ChemPLP=60.55) were the best‐classified compounds compared to the others and they can be explored to develop new repellents.

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Essential Oil Extracted from Cymbopogon citronella Leaves by Supercritical Carbon Dioxide: Antioxidant and Antimicrobial Activities

Cited by 36 publications

References 24 publications

Lemongrass Extract Possesses Potent Anticancer Activity Against Human Colon Cancers, Inhibits Tumorigenesis, Enhances Efficacy of FOLFOX, and Reduces Its Adverse Effects

Lemongrass Extract Possesses Potent Anticancer Activity Against Human Colon Cancers, Inhibits Tumorigenesis, Enhances Efficacy of FOLFOX, and Reduces Its Adverse Effects

Lemongrass (Cymbopogon citratus) Essential Oil: Extraction, Composition, Bioactivity and Uses for Food Preservation – a Review

Identification of Bioactive Compounds against Aedes aegypti (Diptera: Culicidae) by Bioassays and in Silico Assays

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