Establishment of a method for determination of arsenic species in seafood by LC-ICP-MS

Zmozinski, Ariane V.; Llorente-Mirandes, Toni; López-Sánchez, José Fermı́n; Silva, Márcia M. da

doi:10.1016/j.foodchem.2014.10.102

Cited by 58 publications

(42 citation statements)

References 35 publications

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“…Various methods are applied to realize this purpose. Among them, the most often utilized hyphenated technique is high performance liquid chromatography inductively coupled plasma mass spectrometry (HPLC/ICP-MS) [12,15,16,17]; some authors have used other detection techniques, such as inductively coupled plasma optical emission spectrometry (ICP-OES), hydride generation atomic absorption spectrometry (HG-AAS), hydride generation atomic fluorescence spectrometry (HG-AFS), or electrothermal atomic absorption spectrometry (ET-AAS) [4,18,19]. In order to minimize spectral interferences hampering arsenic determination, the dynamic reaction cell (DRC) is often used in ICP-MS instruments [20,21].…”

Section: Introductionmentioning

confidence: 99%

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Total Arsenic and Arsenic Species Determination in Freshwater Fish by ICP-DRC-MS and HPLC/ICP-DRC-MS Techniques

2019

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Analytical methods for the determination of total arsenic (TAs) and arsenic species (arsenite—As(III), arsenate—As(V), monomethylarsenic acid—MMA, dimethylarsenic acid—DMA and arsenobetaine—AsB) in freshwater fish samples were developed. Inductively coupled plasma mass spectrometry with dynamic reaction cell (ICP-DRC-MS) and high-performance liquid chromatography hyphenated to ICP-DRC-MS were used for TAs and arsenic species determination, respectively. The DRC with oxygen as a reaction gas was used. Sample preparation, digestion, and extraction were optimized. Microwave assisted digestion and extraction provided good recovery and extraction efficiency. Arsenic species were fully separated in 8 min using 10 mmol L−1 of ammonium dihydrogen phosphate and 10 mmol L−1 of ammonium nitrate. Overlapping of AsB and As(III) of arsenic species in the presence of a high concentration of AsB and trace amounts of As(III) were studied. Detailed validation of analytical procedures proved the reliability of analytical measurements. Both procedures were characterized by short-term and long-term precision: 2.2% (TAs) up to 4.2% (AsB), and 3.6% (TAs) up to 7.2% (DMA), respectively. Limits of detection (LD) were in the range from 0.056 µg L−1 for TAs to 0.15 µg L−1 for As(V). Obtained recoveries were in the range of 85%–116%. Developed methods were applied to freshwater fish samples analysis.

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Section: Introductionmentioning

confidence: 99%

“…Methanol, water, a mixture of water/methanol in different ratios, and diluted acids are the most frequently used solvents. The most common extraction methods are mechanical stirring, Soxhlet extraction, ultrasound extraction, and microwave-assisted extraction [12,15,16,17,22].…”

Section: Introductionmentioning

confidence: 99%

Total Arsenic and Arsenic Species Determination in Freshwater Fish by ICP-DRC-MS and HPLC/ICP-DRC-MS Techniques

2019

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“…The Agilent Bio SAX stationary phase is based on quaternary ammonium groups (-N + R 3 ), which are therefore expected to be positively charged in the whole pH range (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) of the chromatographic analysis.…”

Section: Hplc-icp-ms Optimization For Arsenic Speciationmentioning

confidence: 99%

“…2,3 Inorganic As is classified as Group I carcinogen, 4,5 being As III (arsenite) more toxic and more mobile than As V (arsenate). [6][7][8][9] The inorganic arsenic species are hundreds of times more toxic than the organic species of monomethylarsonic acid (MMA V ) and dimethylarsinic acid (DMA V ), [10][11][12] while arsenobetaine (AsB) and arsenochloline (AsC), mostly found in fish and aquatic biota, are regarded as nontoxic. [13][14][15][16] Arsenosugars (AsS), mostly found in marine algae, are of low toxicity.…”

Section: Introductionmentioning

confidence: 99%

Arsenic Speciation in Fish and Rice by HPLC-ICP-MS Using Salt Gradient Elution

Nogueira

Melo

Figueiredo

et al. 2018

J. Braz. Chem. Soc.

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This paper presents arsenic speciation studies by high-performance liquid chromatography with inductively coupled plasma-mass spectrometer (HPLC-ICP-MS) using a chromatography column containing a strong anion exchange stationary phase (Agilent Bio SAX G3154A/101) for determination of arsenobetaine (AsB), dimethylarsinic acid (DMA), As III , monomethylarsonic acid (MMA), and As V . The best separation was achieved in 15 min, using a 4 min isocratic step with 1 mM (NH 4 ) 2 HPO 4 pH 10.2, followed by a 2 min salt gradient from 1 to 10 mM, which was kept for 4 min. Compared to the Food and Drug Administration (FDA) method for rice using the PRP-X-100 column, the Bio SAX method was quicker, provided at least equal separation of AsB from the next peak, and led to more symmetrical peaks. The linearity between 0.5 and 60 µg L -1 was shown. The method was tested with 10 µg L -1 fortified rice and fish samples extracted in ultrasound using methanol/water 1:1, and recoveries between 40 and 90% were obtained.

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“…Zmozinski et al. stated that the retention time of As(III) is near the void volume in anion‐exchange column, and it could be coelution of As(III) with AsB and AsC. A combination of anion‐ and cation‐exchange columns was employed to simultaneously separate As species.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous separation and determination of six arsenic species in rice by anion‐exchange chromatography with inductively coupled plasma mass spectrometry

Yang

Tang

et al. 2016

J of Separation Science

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The simultaneous separation and determination of arsenite As(III), arsenate As(V), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), arsenobetaine (AsB), and arsenocholine (AsC) in rice samples have been carried out in one single anion-exchange column run by high-performance liquid chromatography with inductively coupled plasma mass spectrometry. To estimate the effect of variables on arsenic (As) speciation, the chromatographic conditions including type of competing anion, ionic strength, pH of elution buffer, and flow rate of mobile phase have been investigated by a univariate approach. Under the optimum chromatographic conditions, baseline separation of six As species has been achieved within 10 min by gradient elution program using 4 mM NH4 HCO3 at pH 8.6 as mobile phase A and 4 mM NH4 HCO3 , 40 mM NH4 NO3 at pH 8.6 as mobile phase B. The method detection limits for As(III), As(V), MMA, DMA, AsB, and AsC were 0.4, 0.9, 0.2, 0.4, 0.5, and 0.3 μg/kg, respectively. The proposed method has been applied to separation and quantification of As species in real rice samples collected from Hunan Province, China. The main As species detected in all samples were As(III), As(V) and DMA, with inorganic As accounting for over 80% of total As in these samples.

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Establishment of a method for determination of arsenic species in seafood by LC-ICP-MS

Cited by 58 publications

References 35 publications

Total Arsenic and Arsenic Species Determination in Freshwater Fish by ICP-DRC-MS and HPLC/ICP-DRC-MS Techniques

Total Arsenic and Arsenic Species Determination in Freshwater Fish by ICP-DRC-MS and HPLC/ICP-DRC-MS Techniques

Arsenic Speciation in Fish and Rice by HPLC-ICP-MS Using Salt Gradient Elution

Simultaneous separation and determination of six arsenic species in rice by anion‐exchange chromatography with inductively coupled plasma mass spectrometry

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