Establishment of a Mucin-Degrading Intestinal Microflora During the First Two Years of Human Life

Midtvedt, A.-C.; Carlstedt-Duke, B.; Midtvedt, Tore

doi:10.1097/00005176-199404000-00012

Cited by 53 publications

(33 citation statements)

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“…The numbers of bacteria related to A. muciniphila almost doubled in the age period ranging from 6 to 12 months. These data are in agreement with earlier observations (12) which reported the establishment of mucin-degrading microbiota in children from birth to the age of 2 years, based on agar gel electrophoresis of their fecal samples. The establishment of mucin-degrading bacteria was reported during the first months of life and is completed when the children are around 2 years old (12).…”

supporting

confidence: 93%

“…These data are in agreement with earlier observations (12) which reported the establishment of mucin-degrading microbiota in children from birth to the age of 2 years, based on agar gel electrophoresis of their fecal samples. The establishment of mucin-degrading bacteria was reported during the first months of life and is completed when the children are around 2 years old (12). These data indicate that A. muciniphila is colonizing c All data from different age groups were significantly different (P Ͻ 0.05), with only one exception: data from 1-month-old and 6-month-old infants.…”

supporting

confidence: 93%

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Intestinal Integrity and Akkermansia muciniphila , a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly

Collado

Derrien

Isolauri

et al. 2007

Appl Environ Microbiol

591

441

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Fluorescence in situ hybridization and real-time PCR analysis targeting the 16S rRNA gene of Akkermansia muciniphila were performed to determine its presence in the human intestinal tract. These techniques revealed that an A. muciniphila-like bacterium is a common member of the human intestinal tract and that its colonization starts in early life and develops within a year to a level close to that observed in adults (10 8 cells/g) but decreases (P < 0.05) in the elderly.

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supporting

confidence: 93%

supporting

confidence: 93%

Intestinal Integrity and Akkermansia muciniphila , a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly

Collado

Derrien

Isolauri

et al. 2007

Appl Environ Microbiol

591

441

View full text Add to dashboard Cite

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“…An explanation might be that mucins and the other mucin-like glycoproteins present in the breast milk compete with endogenous GI mucins as microbial substrates. 79 A specific transcriptional response to mucin-type oligosaccharides was recently observed in Bifidobacterium spp. in breast fed babies, confirming the reaction of intestinal microbiota to mucin.…”

Section: Mucin Binding By Bacteriamentioning

confidence: 93%

Mucin-bacterial interactions in the human oral cavity and digestive tract

et al. 2010

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“…However, this may only apply to excessive degradation as mucin turnover is a normal part of the colonic ecosystem. MGL homeostasis, with mucin degradation through both bacterial enzymatic processes and peristalsis, occurs shortly after birth 55 , 75 . However in chronic inflammation such as that associated with UC, there is an increased presence of the MDB R. gnavus and torques , 26 , 54 offering a possible explanation for increased mucosa associated bacteria found in IBD.…”

Section: Mucin Degradationmentioning

confidence: 99%

Influences of the colonic microbiome on the mucous gel layer in ulcerative colitis

et al. 2014

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The colonic mucus gel layer (MGL) is a critical component of the innate immune system acting as a physical barrier to microbes, luminal insults, and toxins. Mucins are the major component of the MGL. Selected microbes have the potential to interact with, bind to, and metabolize mucins. The tolerance of the host to the presence of these microbes is critical to maintaining MGL homeostasis. In disease states such as ulcerative colitis (UC), both the mucosa associated microbes and the constituent MGL mucins have been shown to be altered. Evidence is accumulating that implicates the potential for mucin degrading bacteria to negatively impact the MGL and its stasis. These effects appear more pronounced in UC. This review is focused on the host-microbiome interactions within the setting of the MGL. Special focus is given to the mucolytic potential of microbes and their interactions in the setting of the colitic colon.

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Establishment of a Mucin-Degrading Intestinal Microflora During the First Two Years of Human Life

Cited by 53 publications

References 0 publications

Intestinal Integrity and Akkermansia muciniphila , a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly

Intestinal Integrity and Akkermansia muciniphila , a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly

Mucin-bacterial interactions in the human oral cavity and digestive tract

Influences of the colonic microbiome on the mucous gel layer in ulcerative colitis

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