Estimated dietary exposure to veterinary residues in chicken and eggs

Abstract

Background: Chicken tissues and eggs were analyzed for residues of eight veterinary drugs including albendazole, piperazine, tiamulin, chloramphenicol, levamisole, sulphathiazole, sulphamethoxazole and oxytetracyclineoxytetracycline. Results: Mean residue concentrations of all drugs varied by tissue and ranged from 0.004 μg/kg for tiamulin in eggs to 8.6 μg/kg for chloramphenicol in liver. Total residues of all drugs in the liver generally exceeded that of the kidney, muscles and eggs by at least a two-fold difference. The general order of decreasing total drug residue levels is liver > kidney > muscle > eggs. The exposure due to albendazole and sulphamethoxazole in liver were 2-and 7-folds higher than their recommended average daily intake. Exposure due to piperazine, sulphamethoxazole, levamisole and tiamulin were, however, lower than their respective recommended limits. Conclusion: Dietary exposure assessments of all drugs based on quantitated residue levels are within the Joint FAO/ WHO Expert Committee on Food Additives safe regulatory exposure limits. This study informs the public about veterinary drug residues in poultry and helps address policy and regulatory changes in the use of veterinary drugs in poultry.

Human Health Risks Related to Penicillin G and Oxytetracycline Residues Intake Through Beef Consumption and Consumer Knowledge About Drug Residues in Maroua, Far North of Cameroon

“…In comparison to the study conducted in Ghana (16), the GEADE estimated in this study is sometime 260% of ADI. This implies that the concentrations of the antibiotic residues found in the samples present acute toxicity to consumers of Maroua.…”

“…Global estimated acute dietary exposure (GEADE) was calculated based on the 97.5th percentile food consumption amount using the equation as ( 16 ):…”

“…Studies conducted in several countries have highlighted the level of risk faced by populations consuming food of animal origin containing antibiotic residues (15)(16)(17). For example, in Lebanon, the risks due to tetracycline and penicillin residue intake from all dairy products were estimated at 0.007 and 0.006%, respectively (18).…”

Screening of Enrofloxacin and Ciprofloxacin Residues in Chicken Meat by High-Performance Liquid Chromatography

“…The presence of antibiotic residues in animal products above MRL in food-producing animals has serious problems worldwide. Lack of knowledge about the drug withdrawal time and the misuse or overuse of antibiotics lead the formation of antibiotics residues in the animal [15,16]. Many reports indicated that antimicrobial resistance may arise as a result of exposure in animals to these agents and that the resistance may be transferred to human pathogens organisms [17,18].…”

Multi-Class Procedure for Analysis of 50 Antibacterial Compounds in Eggshells Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry

“…The presence of antibiotic residues in food and animal products such as eggs can lead to adverse effects, the most common of which are allergic reactions. Some antibiotics have the potential to cause immunopathological effects, nephropathy, hepatotoxicity, reproductive disorders, and even mutagenicity or carcinogenicity [ 40 , 41 , 42 , 43 ]. The most important adverse effect of antibiotic residues in food is the possibility of inducing antimicrobial resistance (AMR), which has become a significant global threat to human and animal health [ 44 ].…”