Estimated relative bioavailability of supplemental inorganic molybdenum sources and their effect on tissue molybdenum and copper concentrations in lambs

Pott, E. B.; Henry, P. R.; Rao, P. V.; Hinderberger, Edward J; Ammerman, C. B.

doi:10.1016/s0377-8401(99)00019-x

Cited by 10 publications

(2 citation statements)

References 6 publications

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“…Research has demonstrated that Cu toxicity could be reduced by the use of Mo and S supplements, and that low levels of Mo in the feed enhance the deposition of Cu in the liver, leading to Cu excess [6,7]. Despite numerous studies on the separate and combined effects of Cu, Mo, and S on growth performance, mineral stores, and fiber characteristics in lambs [8][9][10][11], in goats [12] or in cattle [13][14][15], there is no consistent conclusion yet. The information on the effects of Cu and Mo supplements or their interactions on cashmere measurements in cashmere goats appears to be limited.…”

Section: Introductionmentioning

confidence: 99%

Effect of Different Levels of Copper and Molybdenum Supplements on Performance, Nutrient Digestibility, and Follicle Characteristics in Cashmere Goats

Zhang

Zhu

et al. 2011

Biol Trace Elem Res

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A 2 × 3 factorial arrangement of treatments was used to investigate the effects of different levels of copper (Cu, 0, 19, and 38 mg/kg, dry matter (DM)) and molybdenum (Mo, 0 and 5 mg/kg, DM) supplements and an interaction of these two factors on growth performance, nutrient digestibility, and cashmere and follicle characteristics in cashmere goats. Thirty-six Liaoning cashmere goats (approximately 1.5 years of age; 27.53 ± 1.38 kg of body weight) were assigned randomly to one of six treatments and fed with Chinese wildrye- and alfalfa hay-based treatment diets (the basal diet contained 4.72 mg Cu/kg, 1.65 mg Mo/kg, and 0.21% S.). Body weight was measured on two consecutive days at the start and the end of the 70-day experimental period. On day 30, the metabolism trial was conducted to study the effects of dietary Cu and Mo on nutrient digestibility. The cashmere and skin samples were collected on day 70. Copper supplementation increased (P < 0.05) growth performance and fiber digestion, but there were no differences (P > 0.05) between Cu-supplemented groups. Addition of 19 mg Cu/kg DM increased (P < 0.05) cashmere growth length or growth rate by increasing the number of active secondary follicles. Molybdenum supplementation decreased (P < 0.05) growth, but did not affect (P > 0.05) nutrient digestion, cashmere, and follicle characteristics. There is a tendency or significant interaction effect of Cu and Mo on growth performance (P = 0.057), cashmere growth (P = 0.076), or diameter (P < 0.05) which might be accomplished by changing the number of secondary follicle and active secondary follicle, and secondary to primary follicle ratio. In conclusion, the optimal supplemental Cu level for Liaoning cashmere goats fed with the basal diet was 19 mg/kg DM (the total dietary Cu level of 23.72 mg/kg DM), while 38 mg Cu/kg DM supplementation was found to be needed when 5 mg Mo/kg was added in the basal diet during the cashmere growing period.

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Section: Introductionmentioning

confidence: 99%

Effect of Different Levels of Copper and Molybdenum Supplements on Performance, Nutrient Digestibility, and Follicle Characteristics in Cashmere Goats

Zhang

Zhu

et al. 2011

Biol Trace Elem Res

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“…Nesta pesquisa, também foi observado que o aumento do Mo da dieta incrementou a concentração de Cu nos rins, o nível serico total de Cu e Cu insolúvel em ATC e excreção diária de cobre pelas fezes. Aparentemente, a biodisponibilidade do Mo estaria dependendo mais da concentração do elemento na dieta que do tempo de consumo, visto que POTT et al (1999a) não observaram diferença quando os animais foram expostos a 14 ou 28 dias de ingestão de Mo, mas quando comparados quatro níveis de Mo na dieta (0, 15, 30 e 45ppm) mostraram que a excreção urinária e fecal de Mo aumentou em forma linear.…”

Section: Fatores Que Influenciam a Interação Cu-mo-sunclassified

Interação cobre, molibdênio e enxofre em ruminantes

2001

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O cobre (Cu) é um componente essencial a varias funções no metabolismo animal. A deficiência de Cu em ruminantes é endêmica em varias regiões ao redor do mundo, especialmente quando as pastagens são altas em molibdênio. O Cu, Mo e enxofre podem se combinar no rúmen para formar complexos triplos não absorvíveis denominados cupro-tiomolibdatos (Cu-TMs). O efeito fisiológico importante dos Cu-TMs está na restrição da disponibilidade de Cu para a síntese de ceruloplasmina. Os ruminantes, especialmente ovinos, são muito mais susceptíveis ao inbalanço Cu:Mo que animais não ruminantes pela relação entre as bactérias rumenais com a geração de sulfeto. Os efeitos de um determinado nível de Cu dietéticos são altamente influenciados pelo índice deste cobre com o molibdênio e enxofre dietéticos.

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Effect of Different Levels of Copper and Molybdenum Supplements on Serum Lipid Profiles and Antioxidant Status in Cashmere Goats

Zhang

et al. 2012

Biol Trace Elem Res

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An experiment was conducted to investigate on the effects of different levels of copper (Cu: 0, 19, and 38 mg/kg) and molybdenum (Mo: 0 and 5 mg/kg) supplements and the interaction of these two factors on serum lipid profiles and antioxidant status in cashmere goats during the cashmere fiber growing period. Thirty-six Liaoning cashmere goats (approximately 1.5 years of age; 27.53±1.38 kg of body weight) were assigned to one of six treatments in a completely randomized design involving a 2×3 factorial arrangement. Goats were housed in individual pens and fed with Chinese wild rye- and alfalfa hay-based diet containing 4.72 mg Cu/kg, 0.16 mg Mo/kg, and 0.21 % S for 84 days. Blood samples were collected on day 84. The triglyceride concentration did not differ among treatments (P>0.05). Supplemental Cu, regardless of Mo level, decreased (P<0.05) the concentrations of serum total cholesterol and low density lipoprotein cholesterol, and increased (P<0.05) the concentration of serum high density lipoprotein cholesterol, but there were no differences (P>0.05) in these values between Cu-supplemented groups. Supplemental Cu increased (P<0.05) the activities of serum ceruloplasmin (Cp), Cu-zinc superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px), and decreased (P<0.05) the malondialdehyde content. The serum GSH-Px activity was also increased (P<0.05) by Mo supplementation. There was a tendency of the interaction effects of Cu and Mo on the activities of Cp (P=0.094), SOD (P=0.057), and GSH-Px (P=0.062), and goats fed with 19 mg Cu/kg in the absence of Mo tended to show the highest serum SOD activity, while goats fed with 38 mg Cu/kg with 5 mg Mo/kg tended to show the highest values of serum Cp and GSH-Px. Addition of Cu, Mo, or their interaction had no influence (P>0.05) on the activities of serum glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, and lactate dehydrogenase, and the concentrations of serum glucose and total protein. In conclusion, addition of 19 mg Cu/kg in the absence of Mo (the total dietary Cu level of 23.72 mg/kg) was recommended for altering the fat metabolism and obtaining the optimal antioxidant activity of cashmere goats, while 38 mg Cu/kg should be supplemented when 5 mg Mo/kg was added in the basal diet (the total dietary level of 42.72 mg Cu/kg, 5.16 mg Mo/kg, and 0.21 % S) during the cashmere growing period.

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Estimated relative bioavailability of supplemental inorganic molybdenum sources and their effect on tissue molybdenum and copper concentrations in lambs

Cited by 10 publications

References 6 publications

Effect of Different Levels of Copper and Molybdenum Supplements on Performance, Nutrient Digestibility, and Follicle Characteristics in Cashmere Goats

Effect of Different Levels of Copper and Molybdenum Supplements on Performance, Nutrient Digestibility, and Follicle Characteristics in Cashmere Goats

Interação cobre, molibdênio e enxofre em ruminantes

Effect of Different Levels of Copper and Molybdenum Supplements on Serum Lipid Profiles and Antioxidant Status in Cashmere Goats

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