Estimates of the cancer incidence and mortality in Europe in 2006

Ferlay, Jacques; Autier, Philippe; Boniol, Mathieu; Heanue, Mary; Colombet, Murielle; Boyle, Peter

doi:10.1093/annonc/mdl498

Cited by 2,457 publications

(1,400 citation statements)

References 15 publications

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“…Our cancer patients and controls differed significantly due to age because breast cancer is a disease mainly prevalent in older women [24], whereas fibroadenoma is the most common benign breast tumor in adolescent girls and young women [38]. In spite of age difference found between the groups compared we did not adjust Cd concentration in breast tissue for age assuming that being a possible environmental-estrogen and accumulating in a human body it could simultaneously explain significance of age to the disease, especially knowing that breast cancer is a disease of postmenopausal women.…”

Section: Resultsmentioning

confidence: 96%

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Cadmium concentration in biological media of breast cancer patients

Strumylaitė

Boguševičius

Abdrachmanovas

et al. 2010

Breast Cancer Res Treat

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The study aimed to determine and compare cadmium (Cd) concentration in different biological media of breast cancer and benign breast tumor patients. Methods Concentration of Cd was determined in breast tissue, urine and blood of 57 breast cancer and 51 benign tumor patients. Two samples of breast tissue from each patient, i.e. tumor and healthy tissue were taken for the analysis. Cd in biological media was determined by atomic absorption spectrometry (Perkin-Elmer, Zeeman 3030). Results The mean Cd concentration in breast cancer patients was 0.053 µg/g (95% CI=0.042-0.065) for tumor sample and 0.02 µg/g (95% CI=0.014-0.026) for healthy breast tissue sample (p<0.001). In benign tumor patients the figures were following: 0.037 µg/g (95% CI=0.023-0.051) and 0.032 µg/g (95% CI=0.018-0.047) (p>0.05). Cd content in malignant tumor significantly differed from that in benign tumor (p<0.01). Cancer patients with positive estrogenreceptors had significantly greater concentration of breast tissue Cd compared to patients with negative estrogenreceptors (p=0.035). Adjusted for creatinine Cd in urine was significantly higher in cancer patients than in controls (p<0.001). In cancer patients a positive Spearman's correlation was found between Cd in tumor and healthy breast tissue, blood (r=0.44 and r=0.39, respectively, p<0.01). Correlation between Cd in urine of cancer patients and number of cigarettes smoked during lifetime was suggestive (r=0.59, p=0.075). Conclusion The data obtained show higher concentration of cadmium in breast tumor and urine of cancer patients and support a possible relationship between cadmium and breast cancer.

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Section: Resultsmentioning

confidence: 96%

“…There was no a significant difference according to Cd found in urine and breast tumor tissue of both smoking differentially cancer patients and controls (p>0.05). [24]. About half of breast cancer cases can be explained by known risk factors related to the reproductive life, inheritance and socioeconomic status [25,26].…”

Section: Resultsmentioning

confidence: 99%

Cadmium concentration in biological media of breast cancer patients

Strumylaitė

Boguševičius

Abdrachmanovas

et al. 2010

Breast Cancer Res Treat

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“…1,2 The widespread use of serum prostate specific antigen (PSA) testing along with increasing public awareness of prostate cancer has resulted in a significant increase in the proportion of patients with clinically localized tumors at the time of diagnosis who likely will not die of the disease. 3 Localized prostate cancers exhibit high levels of genetic, biological and clinical heterogeneity, 4,5 and current prognostic tools (based upon clinicopathologic parameters) are imperfect predictors of disease course.…”

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confidence: 99%

Discovery of circulating microRNAs associated with human prostate cancer using a mouse model of disease

Selth

Townley

Gillis

et al. 2011

Intl Journal of Cancer

177

155

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Circulating microRNAs (miRNAs) are emerging as useful non-invasive markers of disease. The objective of this study was to use a mouse model of prostate cancer as a tool to discover serum miRNAs that could be assessed in a clinical setting. Global miRNA profiling identified 46 miRNAs at significantly altered levels (p 0.05) in the serum of TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP) mice with advanced prostate cancer compared to healthy controls. A subset of these miRNAs with known human homologues were validated in an independent cohort of mice and then measured in serum from men with metastatic castration-resistant prostate cancer (mCRPC; n 5 25) or healthy men (n 5 25). Four miRNAs altered in mice, mmumiR-141, mmu-miR-298, mmu-miR-346 and mmu-miR-375, were also found to be at differential levels in the serum of men with mCRPC. Three of these (hsa-miR-141, hsa-miR-298 and hsa-miR-375) were upregulated in prostate tumors compared with normal prostate tissue, suggesting that they are released into the blood as disease progresses. Moreover, the intra-tumoral expression of hsa-miR-141 and hsa-miR-375 were predictors of biochemical relapse after surgery. This study is the first to demonstrate that specific serum miRNAs are common between human prostate cancer and a mouse model of the disease, highlighting the potential of such models for the discovery of novel biomarkers.Prostate cancer is the most commonly diagnosed non-skin malignancy in men in Western countries, constituting up to 25% of all male cancer diagnoses and 9% of cancer deaths among men in the USA and Europe. 1,2 The widespread use of serum prostate specific antigen (PSA) testing along with increasing public awareness of prostate cancer has resulted in a significant increase in the proportion of patients with clinically localized tumors at the time of diagnosis who likely will not die of the disease. 3 Localized prostate cancers exhibit high levels of genetic, biological and clinical heterogeneity, 4,5 and current prognostic tools (based upon clinicopathologic parameters) are imperfect predictors of disease course. New molecular markers are urgently required to better predict the likely outcome and behavior of individual cancers. microRNAs (miRNAs) are small RNA molecules of 21-23nt that bind with imperfect complementarity to sequences in specific mRNA targets and typically silence their expression by translational inhibition or mRNA decay. miRNAs are estimated to regulate the expression of greater than 60% of all protein-coding genes 6 and, as such, play vital roles in all aspects of normal physiology. Given their biological importance, it is not surprising that miRNA expression is frequently dysregulated in human cancer. 7 Accumulating evidence suggests that miRNAs can contribute to tumorigenesis either by directly modulating oncogenic or tumor suppressor pathways (oncomirs and tumor suppressor miRNAs, respectively) and/or being regulated by oncogenes or tumor suppressor genes. 8 Several characteristics of miRNAs make them ideal biomarkers for...

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“…Some authors estimated that HPV-related cancers at penile, anal, and oropharynx sites are rare among men, occurring in about 1-6/100,000 in the general population [39]. It is estimated that penile cancer amounts to 1/100,000 inhabitants in the Western world, while increases in the Latin America area (1.5-3.7/ 100,000) and East Africa (2.8/100,000) [29,55]. HPV DNA is found in approximately 40-50 % of all penile cancers of the penis and epidemiological studies confirmed the predominant role of HPV 16 and 18 [5].…”

Section: Related Pathologiesmentioning

confidence: 99%

Human papillomavirus (HPV) infection: a Mozambique overview

2016

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Human Papillomavirus is agent of the most common sexually transmitted disease which is able to infect mucosal and cutaneous membranes of the anogenital region, upper aerodigestive tract, and other head and neck mucosal regions. Although mainly HPV infection can be asymptomatic and transient, it may persist and give rise to various lesions such as warts, condyloma dysplasia and cancers depending on low or high risk type of HPV infection. Moreover, growing recent evidence suggests a role of this virus in male and female fertility. To date no effective prevention, test, treatment and control strategies are provided for people in developing countries despite the reported high incidence of HPV both in women and men. This paper reviews the more recent literature about HPV infection highlighting epidemiology, related pathologies and possible fertility effects of HPV in male and female with particular attention to the Mozambique context.

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Estimates of the cancer incidence and mortality in Europe in 2006

Cited by 2,457 publications

References 15 publications

Cadmium concentration in biological media of breast cancer patients

Cadmium concentration in biological media of breast cancer patients

Discovery of circulating microRNAs associated with human prostate cancer using a mouse model of disease

Human papillomavirus (HPV) infection: a Mozambique overview

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