Estimating the Effects of Right Median Nerve Stimulation on Memory in Alzheimer's Disease: A Randomized Controlled Pilot Study

Scherder, E.J.A.; Vuijk, Pieter Jelle; Swaab, Dick F.; Someren, Eus J.W. Van

doi:10.1080/03610730701238915

Cited by 6 publications

(2 citation statements)

References 18 publications

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“…First, Alzheimer patients received transcutaneous neurostimulation over paravertebral back muscles daily during 6 [26] or 3 hours [27,28] for 6 weeks while we used a single 20-minute session of supraorbital neurostimulation. In a more recent randomized sham-controlled pilot trial of right median nerve stimulation, Scherder et al [32] found no significant effect on memory in Alzheimer's disease and the same group reported that cranial electrostimulation had no effect on rest-activity rhythm neither at low frequency [33] nor at high frequency [34]. More interestingly, we found a hypnotic effect with high frequency (120 Hz) stimulation, whereas the beneficial effects in Alzheimer's disease were obtained with burst of stimuli (9 pulses at 160 Hz) delivered at a low frequency of 2 Hz, a frequency that in our study concordantly increased critical flicker fusion frequency.…”

Section: Discussionmentioning

confidence: 99%

Supraorbital transcutaneous neurostimulation has sedative effects in healthy subjects

Piquet¹,

Balestra²,

Sava

et al. 2011

BMC Neurol

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BackgroundTranscutaneous neurostimulation (TNS) at extracephalic sites is a well known treatment of pain. Thanks to recent technical progress, the Cefaly® device now also allows supraorbital TNS. During observational clinical studies, several patients reported decreased vigilance or even sleepiness during a session of supraorbital TNS. We decided therefore to explore in more detail the potential sedative effect of supraorbital TNS, using standardized psychophysical tests in healthy volunteers.MethodsWe performed a double-blind cross-over sham-controlled study on 30 healthy subjects. They underwent a series of 4 vigilance tests (Psychomotor Vigilance Task, Critical Flicker Fusion Frequency, Fatigue Visual Numeric Scale, d2 test). Each subject was tested under 4 different experimental conditions: without the neurostimulation device, with sham supraorbital TNS, with low frequency supraorbital TNS and with high frequency supraorbital TNS.ResultsAs judged by the results of three tests (Psychomotor Vigilance Task, Critical Flicker Fusion Frequency, Fatigue Visual Numeric Scale) there was a statistically significant (p < 0.001) decrease in vigilance and attention during high frequency TNS, while there were no changes during the other experimental conditions. Similarly, performance on the d2 test was impaired during high frequency TNS, but this change was not statistically significant.ConclusionSupraorbital high frequency TNS applied with the Cefaly® device decreases vigilance in healthy volunteers. Additional studies are needed to determine the duration of this effect, the underlying mechanisms and the possible relation with the stimulation parameters. Meanwhile, this effect opens interesting perspectives for the treatment of hyperarousal states and, possibly, insomnia.

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Section: Discussionmentioning

confidence: 99%

Supraorbital transcutaneous neurostimulation has sedative effects in healthy subjects

Piquet¹,

Balestra²,

Sava

et al. 2011

BMC Neurol

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“…In association with MEG, median nerve stimulation has been used to examine evoked responses to somatosensory stimuli in order to examine somatosensory cortical function [ 31 , 36 , 37 ] and ascending pathways from the peripheral receptors to the spinal cord, brainstem, thalamus, and cortex [ 38 ]. This technique has also been used to examine physical and cognitive impairments in individuals with Alzheimer's [ 39 ], stroke patients [ 40 ], and infantile autism [ 41 ], for example. Using MEG, we investigated the oscillatory changes during somatosensory activation in adults with and without ADHD.…”

Section: Introductionmentioning

confidence: 99%

MEG event-related desynchronization and synchronization deficits during basic somatosensory processing in individuals with ADHD

et al. 2008

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Background: Attention-Deficit/Hyperactivity Disorder (ADHD) is a prevalent, complex disorder which is characterized by symptoms of inattention, hyperactivity, and impulsivity. Convergent evidence from neurobiological studies of ADHD identifies dysfunction in fronto-striatal-cerebellar circuitry as the source of behavioural deficits. Recent studies have shown that regions governing basic sensory processing, such as the somatosensory cortex, show abnormalities in those with ADHD suggesting that these processes may also be compromised.

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Current awareness in geriatric psychiatry

2007

Int J Geriat Psychiatry

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of geriatric psychiatry. Each bibliography is divided into 9 sections: 1 Reviews; 2 General; 3 Assessment; 4 Epidemiology; 5 Therapy; 6 Care; 7 Dementia; 8 Depression; 9 Psychology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted

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Estimating the Effects of Right Median Nerve Stimulation on Memory in Alzheimer's Disease: A Randomized Controlled Pilot Study

Cited by 6 publications

References 18 publications

Supraorbital transcutaneous neurostimulation has sedative effects in healthy subjects

Supraorbital transcutaneous neurostimulation has sedative effects in healthy subjects

MEG event-related desynchronization and synchronization deficits during basic somatosensory processing in individuals with ADHD

Current awareness in geriatric psychiatry

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