Estimating the risk of bladder and kidney cancer from exposure to low-levels of arsenic in drinking water, Nova Scotia, Canada

Saint-Jacques, Nathalie; Brown, Patrick; Nauta, Laura; Boxall, James; Parker, Louise; Dummer, Trevor J.B.

doi:10.1016/j.envint.2017.10.014

Cited by 93 publications

(46 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, most of the current frameworks used to regulate arsenic exposure in drinking water have been derived from studies performed in specific populations exposed to high levels of arsenic, such as Bangladesh, Chile, and China [9,133,134]. However, an increased risk of arsenic-related health effects (including cancer) has been documented at levels below current safety thresholds that are commonly found in water sources throughout North America and Europe [7]. Thus, characterizing the effects of these agents at the genomic/epigenomic level will not only aid in determining the oncogenes that are perturbed in environmentally-induced lung cancers, but may also uncover early molecular events that can be used as diagnostic and prognostic markers.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, the molecular aberrations associated with these compounds and the onset of lung cancer in never-smokers follows a mechanism distinct from that of tobacco smoke [5]. While strict guidelines regarding exposure to these compounds have been implemented in some regions, mounting evidence suggests that carcinogenic effects may result from chronic exposure to environmental levels that are well below those currently deemed "safe" [6,7]. Additionally, individual differences may contribute to varying degrees of susceptibility to the carcinogenic effects of these compounds.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oncogenetics of Lung Cancer Induced by Environmental Carcinogens

Martínez¹,

Sage²,

Marshall³

et al. 2019

Oncogenes and Carcinogenesis

View full text Add to dashboard Cite

The molecular landscape of non-tobacco-induced primary lung tumors displays specific oncogenetic features. The etiology of these tumors has been largely associated with exposure to well-established environmental lung carcinogens such as radon, arsenic, and asbestos. Environmental carcinogens can induce specific genetic and epigenetic alterations in lung tissue, leading to aberrant function of lung cancer oncogenes and tumor suppressor genes. These molecular events result in the disruption of key cellular mechanisms, such as protection against oxidative stress and DNA damage-repair, which promotes tumor development and progression. This chapter provides a comprehensive discussion of the specific carcinogenic mechanisms associated with exposure to radon, arsenic, and asbestos. It also summarizes the main protein-coding and non-coding genes affected by exposure to these environmental agents, and the underlying molecular mechanisms promoting their deregulation in lung cancer. Finally, the chapter examines the anticipated challenges in personalized intervention strategies in non-tobacco-induced lung cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oncogenetics of Lung Cancer Induced by Environmental Carcinogens

Martínez¹,

Sage²,

Marshall³

et al. 2019

Oncogenes and Carcinogenesis

View full text Add to dashboard Cite

show abstract

“…Association and risk of occupational exposure for KCa distribution Table 5shows socio demographic distribution as mean age from all studies was 56.45±17.6 and male were majority with average percentage of 95.3% and about 42.5% were smokers. Table 6 and Figure 4 shows association and risk of occupational exposure for renal cancer distribution.Peters et al 20 (OR 1.63, 95% CI: 1.33-1.96), Saint-Jacques et al 22 (OR 1.808, 95% CI: 1.34-2.43) and Michelek et al 23 (OR 1.842, 95% CI: 1.53-2.18) showed significant risk but Michelek et al 23 (OR 0.81, 95% CI: 0.71-1.15 ), Zaitsu et al 19 (OR 1.04,95% CI: 0.96-1.12) and Callahan et al 24 (0.95, 95% CI: 0.84-1.37 ) showed no significant risk or association. After analysis of multiple paper regarding the association between KCa and different occupational exposure we found no significant association (OR 1.04, 95% CI:0.94-1.34).…”

Section: Categorical Meta-analysis Findingsmentioning

confidence: 97%

“…For the studies that investigated the association of occupational exposure and risk of KCa; there were 4 case control studies, 17,20,21,24 3 cohort studies18, 19,23 and 1 ecological study 22 they were all population based studies. For the studies that investigated the association of occupational exposures and risk of bladder cancer; there were 5 case control studies, 26,30,31,34,35 3 cohort studies, 25,28,33 2 cross sectional studies, 27,29 and 1 social perspective.…”

Section: Quality Assessment Of Studiesmentioning

confidence: 99%

Occupational exposure as risk factor for kidney and bladder cancer: a systematic review and meta-analysis

Deb¹,

Okechukwu²,

Emara³

et al. 2019

UNOAJ

View full text Add to dashboard Cite

Background: Occupational exposure plays a huge role in the epidemiology, pathogenesis and prevalence of kidney cancer (KCa) and bladder cancer (BCa) worldwide. Objective: The aim of this study was to analyze qualitatively and quantitatively the association between occupational exposure and risk of KCa and BCa. Method: We identified peer-reviewed articles published in English by searching PubMed, Embase, Surveillance, Epidemiology, and End Results (SEER) and Cochrane databases. We selected articles published between January 2018 to May 2019. We summed up all relative risk estimates to ensure accuracy, comprehensiveness and maximize statistical power given the low absolute occupational risk of KCa, occupational risk of BCa and standardized incidence ratios (SIRs). We reported this systematic review and meta-analysis in accordance with the Preferred Reporting Items for Systematic Reviews and metaanalyses (PRISMA) checklist. Quantitative analyzes was performed using Comprehensive Meta-Analysis version 3 (Biostat, Inc, Englewood, New Jersey, USA). Results:We found no significant association between occupational exposure and KCa (OR 1.04, 95% CI: 0.94-1.34), but there was a significant association between occupational exposure and BCa (OR 1.54, 95% CI: 1.44-1.75). Conclusion:From the result of our qualitative and quantitative analysis there was no significant association between occupational exposure and KCa whereas there was a significant association between occupational exposure and BCa.

show abstract

“…A rsenic contamination represents a growing public health concern in numerous countries across the globe (Mukherjee et al 2006; Uddin and Huda 2011; Alarcón‐Herrera et al 2013; Huang et al 2015; Ayotte et al 2017; Hsu et al 2017; Malloch et al 2017; Saint‐Jacques et al 2018; Zeng et al 2018). It has been responsible for some of the most devastating natural mass poisoning incidents in recent times, according to the World Health Organization (WHO) (Flanagan et al 2012), and represents a looming threat as concerns about water security and water shortages increase (IPCC 2013, 2014).…”

mentioning

confidence: 99%

Arsenic Concentrations in Ground and Surface Waters across Arizona Including Native Lands

Jones

Credo

Ingram

et al. 2020

Contemporary Water Research

View full text Add to dashboard Cite

Parts of the Southwestern United States report arsenic levels in water resources that are above the United States Environmental Protection Agency's current drinking water limits. Prolonged exposure to arsenic through food and drinking water can contribute to significant health problems including cancer, developmental effects, cardiovascular disease, neurotoxicity, and diabetes. In order to understand exposure risks, water sampling and testing have been conducted throughout Arizona. This information is available to the public through often non‐overlapping databases that are difficult to access and in impracticable formats. The current study utilized a systemic compilation of online databases to compile a spreadsheet containing over 33,000 water samples. The reported arsenic concentrations from these databases were collected from 1990–2017. Using ArcGIS software, these data were converted into a map shapefile and overlaid onto a map of Arizona. This visual representation shows that arsenic levels in surface and ground water exceed the United States Environmental Protection Agency's drinking water limits for many sites in several counties in Arizona, and there is an underrepresentation of sampling in several tribal jurisdictions. This information is useful for water managers and private well owners throughout the State for determining safe drinking water sources and limiting exposure to arsenic.

show abstract

Estimating the risk of bladder and kidney cancer from exposure to low-levels of arsenic in drinking water, Nova Scotia, Canada

Cited by 93 publications

References 65 publications

Oncogenetics of Lung Cancer Induced by Environmental Carcinogens

Oncogenetics of Lung Cancer Induced by Environmental Carcinogens

Occupational exposure as risk factor for kidney and bladder cancer: a systematic review and meta-analysis

Arsenic Concentrations in Ground and Surface Waters across Arizona Including Native Lands

Contact Info

Product

Resources

About