Evapotranspiration (ET) is a crucial process in the terrestrial water cycle, and understanding its stable isotopic evolution is essential for comprehending hydrological processes. The Craig–Gordon (C-G) model is widely used to describe isotopic fractionation during pure evaporation. However, in natural environments, ET involves both transpiration (T) and evaporation (E), and the traditional C-G model does not account for the effect of transpiration on isotopic fractionation. To address this gap, we propose the evapotranspiration-unified C-G (ET-UCG) model, which extends the C-G model by incorporating transpiration’s effect on water isotopes. We verified the validity of the ET-UCG model by comparing its simulation results with the traditional C-G model’s discrete results for a special scenario that simulated the isotopic evolution of residual water after daily transpiration consumption. Further, we simulated two different ET process scenarios using the ET-UCG model to investigate transpiration’s effect on the residual water’s isotopic composition. Our numerical experiments show that transpiration indirectly affects the degree of water isotope fractionation by reducing the true evaporation ratio, even though it does not directly produce isotope fractionation. Therefore, the isotopic composition of residual water estimated by the ET-UCG model is consistently lighter than that estimated using the traditional C-G model in the simulation of ET. Despite different T/ET conditions, the isotopic evolution process follows the same evaporation line. These results highlight the importance of considering transpiration effects when using the C-G model and provide valuable insights into ET processes with potential applications in the field.