ESTIMATION OF ESTROGENIC AND TOXIC POTENCIES OF SUGAR BEET'S PLANT<i>(BETA VULGARIS)</i>AND SILAGE IN MICE

Grünert, E; Elghamry, M. I.; Aehnelt, E

doi:10.1055/s-0028-1099830

Planta Med

1969

DOI: 10.1055/s-0028-1099830

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ESTIMATION OF ESTROGENIC AND TOXIC POTENCIES OF SUGAR BEET'S PLANT(BETA VULGARIS)AND SILAGE IN MICE

E Grünert¹,

M. I. Elghamry²,

E Aehnelt³

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Cited by 4 publications

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“…Beet leaves, on the other hand, appear to be estrogenic; cattle fed large amounts of sugar beet leaves (from a different variety of the same species as red beets) manifested infertility and genital tract abnormalities, and several fractions of sugar beet leaves injected subcutaneously increased uterine weights in mice (a test for estrogenicity) (Elghamry et al, 1970(Elghamry et al, -1971. Root extracts, however, had no apparent estrogenic effects in doses as high as 20 mg daily (Grunert et al, 1969). A novel isoflavone, 5,2 -dihydroxy-6,7-methylenedioxyisoflavone, has been isolated from the seed balls of sugar beet (Chiji et al, 1986), but no animal or in vitro studies on this isoflavone were identified.…”

mentioning

confidence: 96%

Treatment of fibroids: the use of beets (Beta vulgaris) and molasses (Saccharum officinarum) as an herbal therapy by Dominican healers in New York City

Fugh‐Berman

Balick

Kronenberg

et al. 2004

Journal of Ethnopharmacology

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mentioning

confidence: 96%

Treatment of fibroids: the use of beets (Beta vulgaris) and molasses (Saccharum officinarum) as an herbal therapy by Dominican healers in New York City

Fugh‐Berman

Balick

Kronenberg

et al. 2004

Journal of Ethnopharmacology

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Potential Value of Plants as Sources of New Antifertility Agents II *

Farnsworth¹,

Bingel

Cordell

et al. 1975

Journal of Pharmaceutical Sciences

263

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E-Screen evaluation of sugar beet feedstuffs in a case of reduced embryo transfer efficiencies in cattle: the role of phytoestrogens and zearalenone

Shappell

Mostrom

Lenneman

2012

In Vitro Cell.Dev.Biol.-Animal

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The E-Screen assay was used to evaluate the estrogenicity of sugar beet by-products obtained from a dairy farm experiencing low success rates of embryo transfer. The beet tailings had ~3-fold the estradiol equivalents of the pelleted beet pulp (3.9 and 1.2 μg estradiol equivalents or E(2)Eq/kg dry matter, respectively). Whole sugar beets, sugar beet pellets, and shreds from several Midwest US locations were also evaluated by E-Screen. All pellets examined were found to have some estrogenic activity (range ~0.1-2.0 μg E(2)Eq/kg DM) with a mean of 0.46 μg/kg dry matter and median of 0.28 μg/kg dry matter. Relative E(2)Eq ranked as follows: pellets > shreds > most unprocessed roots. Using recommended feeding levels and conservative absorption estimates (10%), the estrogenic activity in the original samples could result in blood estradiol equivalents ≥ those found at estrus (10 pg/mL, cows). Chemical analyses revealed no known phytoestrogens, but the estrogenic mycotoxin, zearalenone, was found in 15 of 21 samples. Of significance to those using the E-Screen are our findings that contradict previous reports: ß-sitosterol has no proliferative effect and genistein's glucuronidated form-genistin-is equal to genistein in proliferative effect. The latter is the result of deconjugation of genistin to genistein in the presence of fetal bovine serum (determined by LC MSMS). These data show the usefulness and caveats of the E-Screen in evaluation of feedstuffs, and indicate a potential for sugar beet by-products to contain zearalenone at concentrations that may impact reproduction.

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ESTIMATION OF ESTROGENIC AND TOXIC POTENCIES OF SUGAR BEET'S PLANT(BETA VULGARIS)AND SILAGE IN MICE

Cited by 4 publications

References 0 publications

Treatment of fibroids: the use of beets (Beta vulgaris) and molasses (Saccharum officinarum) as an herbal therapy by Dominican healers in New York City

Treatment of fibroids: the use of beets (Beta vulgaris) and molasses (Saccharum officinarum) as an herbal therapy by Dominican healers in New York City

Potential Value of Plants as Sources of New Antifertility Agents II *

E-Screen evaluation of sugar beet feedstuffs in a case of reduced embryo transfer efficiencies in cattle: the role of phytoestrogens and zearalenone

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