Estimation of human leukocyte antigen class I and class II high-resolution allele and haplotype frequencies in the Italian population and comparison with other European populations

Rendine, S.; Ferrero, Norma; Sacchi, Nicoletta; Costa, Cristina; Pollichieni, Simona; Amoroso, Antonio

doi:10.1016/j.humimm.2012.01.005

Cited by 47 publications

(48 citation statements)

References 15 publications

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“…The frequencies of HLA‐A, ‐B, ‐C, ‐DRB1 and ‐DQB1 alleles, including the relative frequencies inside each allelic group, are listed in Tables and . Our data are comparable to those reported for healthy Italian donors recruited in the Italian Bone Marrow Donor Registry (IBMDR) . For class I, a total of 37 HLA‐A, 52 HLA‐B and 31 HLA‐C alleles were identified, while in class II we identified 38 DRB1 and 17 DQB1 different alleles.…”

Section: Resultsmentioning

confidence: 56%

Influence of the HLA characteristics of Italian patients on donor search outcome in unrelated hematopoietic stem cell transplantation

et al. 2014

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The information regarding the probability of finding a matched unrelated donor (MUD) within a relatively short time is crucial for the success of hematopoietic stem cell transplantation (HSCT), particularly in patients with malignancies. In this study, we retrospectively analyzed 315 Italian patients who started a search for a MUD, in order to assess the distribution of human leukocyte antigen (HLA) alleles and haplotypes in this population of patients and to evaluate the probability of finding a donor. Comparing two groups of patients based on whether or not a 10/10 HLA-matched donor was available, we found that patients who had a fully-matched MUD possessed at least one frequent haplotype more often than the others (45.6% vs 14.3%; P = 0.000003). In addition, analysis of data pertaining to the HLA class I alleles distribution showed that, in the first group of patients, less common alleles were under-represented (20.2% vs 40.0%; P = 0.006). Therefore, the presence of less frequent alleles represents a negative factor for the search for a potential compatible donor being successful, whereas the presence of one frequent haplotype represents a positive predictive factor. Antigenic differences between patient and donor observed at C and DQB1 loci, were mostly represented by particular B/C or DRB1/DQB1 allelic associations. Thus, having a particular B or DRB1 allele, linked to multiple C or DQB1 alleles, respectively, might be considered to be associated with a lower probability of a successful search. Taken together, these data may help determine in advance the probability of finding a suitable unrelated donor for an Italian patient.

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Section: Resultsmentioning

confidence: 56%

Influence of the HLA characteristics of Italian patients on donor search outcome in unrelated hematopoietic stem cell transplantation

et al. 2014

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“…These results show HLA genetic characteristics of both Mediterranean and Near East populations; also one Eurasiatic haplotype is found in a relatively high frequency. References for Table 4 footnote are: a [45], b [32, 36, 41], c [45], d [35], e [32, 33, 39, 41, 46], f [38], g [32, 33, 38, 41, 47, 48, 49], h [50], i [35], k [35], j [45] and l [51]. …”

Section: Resultsmentioning

confidence: 99%

Genetic HLA Study of Kurds in Iraq, Iran and Tbilisi (Caucasus, Georgia): Relatedness and Medical Implications

Arnaiz‐Villena¹,

Palacio-Grüber²,

Muñiz³

et al. 2017

PLoS ONE

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Kurds from Iraq (Dohuk and Erbil Area, North Iraq) have been analyzed for HLA genes. Their HLA genetic profile has been compared with that of other Kurd groups from Iran and Tbilisi (Georgia, Caucasus) and also Worldwide populations. A total of 7,746 HLA chromosomes have been used. Genetic distances, NJ dendrograms and correspondence analyses have been carried out. Haplotype HLA-B*52—DRB1*15 is present in all three analyzed Kurd populations. HLA-A*02-B*51-DRB1*11 is present in Iraq and Georgia Kurds. Haplotypes common to Iran and Iraq Kurds are HLA DRB1*11—DQB1*03, HLA DRB1*03—DQB1*02 and others in a lower frequency. Our HLA study conclusions are that Kurds most probably belong to an ancient Mediterranean / Middle East / Caucasian genetic substratum and that present results and those previously obtained by us in Kurds may be useful for Medicine in future Kurd transplantation programs, HLA Epidemiology (HLA linked diseases) and Pharmacogenomics (HLA-associated drug side effects) and also for Anthropology. It is discussed that one of the most ancient Kurd ancestor groups is in Hurrians (2,000 years BC).

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“…Under the dominant model, the genotype DRB1*03:01‐DQB1*02:01 accounted for 42.3% of the PAR in our population group. However, the carrier rate of the DR3 haplotype in the Taiwanese population is lower than that of Caucasians, which may partially explain the lower incidence of T1D in Taiwan . Furthermore, we even detected LD in the extended 5‐locus haplotype C*03:02‐B*58:01‐DRB1*03:01‐DQB1*02:01‐DPB1*04:01.…”

Section: Discussionmentioning

confidence: 70%

Comprehensive human leukocyte antigen genotyping of patients with type 1 diabetes mellitus in Taiwan

et al. 2018

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Estimation of human leukocyte antigen class I and class II high-resolution allele and haplotype frequencies in the Italian population and comparison with other European populations

Cited by 47 publications

References 15 publications

Influence of the HLA characteristics of Italian patients on donor search outcome in unrelated hematopoietic stem cell transplantation

Influence of the HLA characteristics of Italian patients on donor search outcome in unrelated hematopoietic stem cell transplantation

Genetic HLA Study of Kurds in Iraq, Iran and Tbilisi (Caucasus, Georgia): Relatedness and Medical Implications

Comprehensive human leukocyte antigen genotyping of patients with type 1 diabetes mellitus in Taiwan

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