Estimation of Serum Copper and Zinc Levels in Oral Submucous Fibrosis: An Atomic Absorption Spectroscopic Study

Neethi, H; Patil, Shankargouda; Rao, Roopa S

doi:10.5005/jp-journals-10024-1406

Cited by 7 publications

(3 citation statements)

References 9 publications

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“…Similar contradictory observations have been reported by previous studies. 20,21 23 We found males were mostly involved in areca nut product consumption and these findings are consistent with Okade et al 13 who reported 96.6% male population in their recent study. Similar male proclivity was reported by a previous study.…”

Section: Discussionsupporting

confidence: 90%

Serum Copper and Zinc Levels of Oral Submucous Fibrosis Patients Using Areca Nut Products Reported at Isra University Hospital Hyderabad

Tariq¹,

Iqbal²,

Channa³

et al. 2021

PJMHS

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Objective: To determine the copper and zinc levels in serum among oral submucous fibrosis patients using various areca nut products by taking healthy individuals as control at Isra University Hospital Hyderabad. Methodology: This descriptive case-control study was conducted on patients of oral submucosal fibrosis (OSMF) attending the Outpatient Department, Oral Surgery Isra Dental College, Isra university during a period of one year from November 2016 to October 2017. A total of 30 patients above 16 years of age and who were diagnosed cases of OSMF and gave history of areca nut and its commercial products consumption for more than one year were included as group (B)and in equal number healthy individuals were enrolled as control as group(A). The 6ml blood sample was collected in gel tube and then we centrifuged at 3000 rpm gravity for 10min to separate the serum from blood. The 4 to 5ml serum collected in this way was analyzed by spectrophotometric method on Hitachi 902(Roche Germany). The levels of copper and zinc were estimated from serum of both groups. All the data was collected via study proforma and analysis of the data was done by using SPSS version 20. Results: Mean age of the patients was 23.33±4.97 years and mean age of healthy controls was 22.80±4.61 years. The males were most common in both groups. Manipuri was commonest consumed areca nut (50.0%) followed by sweet scented areca nut and Gutkha 33.3% and 36.6% respectively. Mean of serum Cu in patients was lower 86±4.20 µg/dl in contrast to controls 114.0±13.8 µg/dl (p-0.0001). Average of serum Zinc was higher among patients 94.20±15.11 µg/dl as compared to controls as 68.06±17.10 µg/dl (p-0.0001). Conclusion: The average of serum copper level was observed to be significantly less and average of serum zinc significantly higher among OSMF patients using areca nut as compared to healthy individuals. These serum trace element levels could be used as potential prognostic and diagnostic markers in the OSMF patients. Key words: OSMF, Zinc, Copper, Areca nut

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Section: Discussionsupporting

confidence: 90%

Serum Copper and Zinc Levels of Oral Submucous Fibrosis Patients Using Areca Nut Products Reported at Isra University Hospital Hyderabad

Tariq¹,

Iqbal²,

Channa³

et al. 2021

PJMHS

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“…They even concluded that early evaluation of serum zinc levels contributes to early diagnosis of disease. 16 The present study used atomic absorption spectroscopy for evaluation of salivary levels which is expensive and may not available in all clinical setups but has exceptional accuracy. We further recommend the correlation of salivary levels with the clinical staging of OSMF.…”

Section: Discussionmentioning

confidence: 99%

Salivary Evaluation of trace Elements in Oral Submucous Fibrosis– An Atom Absorption Spectroscopic Study

Kanjani¹

2019

jmscr

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Introduction: Oral submucous fibrosis is chronic debilitating disease of oral mucosa, associated with consumption of arecanut, causing mucosal progressive fibrosis and restricted mouth opening. The premalignant nature of OSMF is multifactorial. Trace elements such as copper and zinc are involved in various enzymatic reactions thereby acting as diagnostic and prognostic marker in oral lesions. Therefore, the present study was conducted to evaluate the salivary levels of copper and zinc in OSMF patients and to compare it with matched healthy individuals. Material and Methods: The present case control study included 40 clinically diagnosed OSMF cases and 40 matched healthy controls of age range of 25 -60 years. Along with questionnaire, the clinical examination was performed. The unstimulated saliva samples were collected from all participants in sterile containers and assessed for copper and zinc levels using atomic absorption spectroscopy. The obtained data was compiled and analyzed using SPSS software version 21.0. Results: In the present study, the mean salivary levels of copper in OSMF cases and controls were 83. 38 ± 4.83 μg/dL and 42.84 ± 3.38 μg/Dl respectively. The mean salivary zinc levels were 23.54 ± 3.46 μg/dL and 37.32 ± 4.82 μg/dL in OSMF cases and controls respectively. The results showed significant difference in levels of salivary copper and zinc in OSMF cases as compared to healthy controls with p value of less than 0.05. Conclusion:The present study revealed that trace elements can be used as diagnostic and prognostic marker in oral premalignant and malignant lesions.

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“…Both the biological sample and gender did not affect the difference in the levels of trace elements between OSF and healthy controls. The level of plasma/serum/saliva Zn in OSF participants has been evaluated in numerous investigations [ 4 , 23 , 26 , 27 , 29 – 31 , 35 , 37 , 55 ]. Only four of these did not report lower Zn levels in OSF patients [ 12 , 28 , 34 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis

Sachdev

Freeland‐Graves

Beretvas

et al. 2018

International Journal of Dentistry

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Oral submucous fibrosis (OSF) is a potentially malignant disorder which causes fibrosis and inflammation of the oral mucosa. Studies have reported altered levels of trace elements in oral submucous fibrosis subjects, but findings have been inconsistent. The objective of this research is to perform a meta-analysis to summarize studies that report zinc (Zn), copper (Cu), and iron (Fe) in patients, with and without OSF. A literature search of Embase, PubMed, Cochrane Library, and Web of Science electronic databases was conducted for studies up to January 2017. A total of 34 reports met the inclusion criteria. The standardized mean difference was utilized as the effect size. The robust variance estimation method was chosen to handle dependency of multiple related outcomes in meta-analysis. There was a significant increase in the levels of Cu (effect size = 1.17, p value < 0.05, 95% confidence interval (CI): 0.164–2.171) and a significant decrease in levels of Zn (effect size = −1.95, p value < 0.05, 95% CI: −3.524 to −0.367) and Fe (effect size = −2.77, p value < 0.01, 95% CI: −4.126 to −1.406) in OSF patients. The estimation of Zn, Cu, and Fe levels may serve as additional biomarkers in the diagnosis and prognosis of OSF along with the clinical features.

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Estimation of Serum Copper and Zinc Levels in Oral Submucous Fibrosis: An Atomic Absorption Spectroscopic Study

Cited by 7 publications

References 9 publications

Serum Copper and Zinc Levels of Oral Submucous Fibrosis Patients Using Areca Nut Products Reported at Isra University Hospital Hyderabad

Serum Copper and Zinc Levels of Oral Submucous Fibrosis Patients Using Areca Nut Products Reported at Isra University Hospital Hyderabad

Salivary Evaluation of trace Elements in Oral Submucous Fibrosis– An Atom Absorption Spectroscopic Study

Zinc, Copper, and Iron in Oral Submucous Fibrosis: A Meta-Analysis

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