Estimation of the Exposure and a Risk-Benefit Analysis for a CT System Designed for a Lung Cancer Mass Screening Unit

Nishizawa, Kanae; Iwai, Keisuke; Matsumoto, Teppei; Sakashita, Kentaro; Iinuma, Toshio; Tateno, Yukio; Miyamoto, Tomofumi; Shimura, A; Takagi, Haruyuki

doi:10.1093/oxfordjournals.rpd.a031801

Cited by 16 publications

(11 citation statements)

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“…According to Nishizawa et al (1996), the effective dose using low-dose CT scan of the chest is 3.6 mSv and the surface dose is 7.6 mGy, when CT scans are performed with a tube current set at 50 mA. Their risks-benefits analysis indicated that the benefits of annual CT screening for lung cancer outweigh the risk in men aged 40 years and women aged 45 years.…”

Section: Discussionmentioning

confidence: 99%

Results of three-year mass screening programme for lung cancer using mobile low-dose spiral computed tomography scanner

et al. 2001

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SummaryThe aim of this study was to evaluate the usefulness of annual screening for lung cancer by low-dose computed tomography (CT) and the characteristics of identified lung cancers. Subjects consisted of 5483 general population aged 40-74 years, who received initial CT scans in 1996, followed by repeat annual scans for most subjects in 1997 and 1998, with a total of 13 786 scans taken during 1996-1998. Work-up examinations for patients with suspicious lesions were conducted using diagnostic CTs. The initial screening in 1996 detected suspicious nodules in 279 (5.1%) of 5483 subjects, and 22 (8%) were confirmed surgically to have lung cancer. Corresponding figures in 1997 and 1998 screening studies were 173 (3.9%) of 4425 and 25 (14%) of 173, and 136 (3.5%) of 3878 and 9 (7%) of 136, respectively. The sensitivity and specificity of detecting surgically confirmed lung cancer were 55% (22/40) and 95% (4960/5199) in 1996 and 83% (25/30) and 97% (4113/4252) in 1997 screening, respectively. 88% (55/60) of lung cancers identified on screening and surgically confirmed were AJCC stage IA. Our trial allowed detection of nearly 11 times the expected annual number of early lung cancers. Repeat CT allowed the detection of more aggressive, rapidly growing lung cancers, compared to those in the initial screening. 25-32 © 2001 Cancer Research Campaign doi: 10.1054/ bjoc.2000.1531 available online at http://www.idealibrary.com on http://www.bjcancer.com to 150 detected SSPNs from these screenees. A much larger series of SSPN is required to study the second question, the prevalence of malignancy among the detected SSPNs, by getting an appreciable number of malignant SSPN, because the prevalence of malignant SSPN among high-risk population is estimated to be of the order of 1%. We defined our sample size of 5000 to 10 000, which was fairly larger than that indicated by Henschke et al, because we aimed to conduct our trial of CT screening for lung cancer using CT among the general population, which included never-smoked inhabitants in this rural area in Japan. In our study, inhabitants of 29 local municipalities in the Nagano Prefecture, Japan, who were 40 years of age or older were specifically requested in 1996 to volunteer for this programme. The annual mortality rate due to lung cancer in the same region was 37.3 per 100 000 population in 1998. Therefore, it was expected in our trial at least nearly 100 SSPNs be detected at each annual screening to undergo work-up examination, which would permit us to estimate the probability of CT-detected SSPN. Although we expected to encounter at least several cases with lung cancer among the total 5000 to 10 000 participants, we were not sure about the expected number of cancer cases because no information on this aspect was available. All subjects gave informed consent to receive base line and annual repeat CT scans of the thorax. SubjectsThe material of this study comprised a total of 13 786 CT examinations, including 5483 initial CT scans in 1996, 4425 first-year repeat CT scans in...

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Section: Discussionmentioning

confidence: 99%

Results of three-year mass screening programme for lung cancer using mobile low-dose spiral computed tomography scanner

et al. 2001

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“…For low-dose CT lung examinations, current-exposure-time settings typically range from 30 to 100 mAs (1-7); the National Lung Screening Trial protocol (8) recommends 60 mAs. In the calculations that follow, we have used a direct measurement by Nishizawa et al (39), scaled to a current-exposure-time setting of 60 mAs, which yields a dose of 5.2 mGy Ϯ 0.9 to the lung.…”

Section: Radiation Doses To the Lung From Low-dose Ct Lung Screeningmentioning

confidence: 99%

Radiation Risks Potentially Associated with Low-Dose CT Screening of Adult Smokers for Lung Cancer

Brenner¹

2004

Radiology

406

240

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“…A previous study reported that the background dose was 8.71 mGy in the lung, with an effective dose that ranged between 3.61 and 3.64 mSv (ICRP 60) using an anthropomorphic phantom, which is a model of a Japanese adult (RANDO; Alderson Research Laboratory, Salem, NY, USA, 163 cm height, 53 kg weight, without legs or arms) (Nishizawa et al 1996). The scanning parameters for lung cancer used for a single spiral CT were 120 kVp and 50 mA, a slice thickness of 10 mm, tube rotation speed of 2 s, a reconstructed image pitch of 10 mm, and a table speed of 10 mm/s.…”

Section: Discussionmentioning

confidence: 99%

Low-dose CT scan screening for lung cancer: comparison of images and radiation doses between low-dose CT and follow-up standard diagnostic CT

et al. 2013

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ObjectivesThis study aim to compare image quality and radiation doses between low-dose CT and follow-up standard diagnostic CT for lung cancer screening.MethodsIn a single medical institution, 19 subjects who had been screened for lung cancer by low-dose CT before going through follow-up standard diagnostic CT were randomly selected. Both CT image sets for all subjects were independently evaluated by five specialized physicians.ResultsThere were no significant differences between low-dose CT screening and follow-up standard diagnostic CT for lung cancer screening in all 11 criteria. The concordance rate for the diagnoses was approximately 80% (p < 0.001) for all categories. Agreement of the evaluation of all categories in the final diagnosis exceeded 94% (p < 0.001). Five physicians detecting and characterizing the pulmonary nodules did not recognized the difference between low-dose CT screening and follow-up standard diagnostic CT. With low-dose CT, the effective dose ranged between 1.3 and 3.4 mSv, whereas in the follow-up diagnostic CT, the effective dose ranged between 8.5 and 14.0 mSv.ConclusionThis study suggests that low-dose CT can be effectively used as a follow-up standard diagnostic CT in place of standard-dose CT in order to reduce the radiation dose.

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Estimation of the Exposure and a Risk-Benefit Analysis for a CT System Designed for a Lung Cancer Mass Screening Unit

Cited by 16 publications

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Results of three-year mass screening programme for lung cancer using mobile low-dose spiral computed tomography scanner

Results of three-year mass screening programme for lung cancer using mobile low-dose spiral computed tomography scanner

Radiation Risks Potentially Associated with Low-Dose CT Screening of Adult Smokers for Lung Cancer

Low-dose CT scan screening for lung cancer: comparison of images and radiation doses between low-dose CT and follow-up standard diagnostic CT

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