Estrogen and estrogen-progesterone treatments counteract the effect of scopolamine on reinforced T-maze alternation in female rats.

Dohanich, Gary P.; Fader, Aric J.; Javorsky, Debbie J.

doi:10.1037/0735-7044.108.5.988

Cited by 94 publications

(43 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…E2 administration up to 72 hours prior to testing to ovariectomized rats completely counteracted the negative learning effects of the cholinergic antagonist scopolamine on alternation learning (Dohanich et al 1994). E2 replacement in ovariectomized rats enhanced acquisition of spatial memory tasks and partially blunted the effects of hippocampal administration of the anticholinergic scopolamine (Gibbs 1999).…”

Section: Discussionmentioning

confidence: 90%

Estradiol interacts with the cholinergic system to affect verbal memory in postmenopausal women: Evidence for the critical period hypothesis

Dumas

Hancur-Bucci

Naylor

et al. 2008

Hormones and Behavior

View full text Add to dashboard Cite

Estradiol has been shown to interact with the cholinergic system to affect cognition in postmenopausal women. This study further investigated the interaction of estradiol and cholinergic system functioning on verbal memory and attention in two groups of healthy younger (ages 50-62) and older (ages 70-80) postmenopausal women. Twenty-two postmenopausal women were randomly and blindly placed on 1 mg of 17-beta estradiol orally for one month then 2 mg for two months or matching placebo pills after which they participated in three anticholinergic challenge sessions when verbal memory performance was assessed. Subjects were administered either the antimuscarinic drug scopolamine (SCOP), the antinicotinic drug mecamylamine (MECA) or placebo. After the first challenge phase, they were crossed over to the other hormone treatment for another three months and repeated the challenges. Results showed that estradiol pretreatment significantly attenuated the anticholinergic drug-induced impairments on a test of episodic memory (the Buschke Selective Reminding test) for the younger group only, while estradiol treatment impaired performance of the older group. The results suggest that younger subjects may experience more cholinergic benefit from estradiol treatment than older subjects, supporting the concept of a critical period for postmenopausal estrogen use.

show abstract

Section: Discussionmentioning

confidence: 90%

Estradiol interacts with the cholinergic system to affect verbal memory in postmenopausal women: Evidence for the critical period hypothesis

Dumas

Hancur-Bucci

Naylor

et al. 2008

Hormones and Behavior

View full text Add to dashboard Cite

show abstract

“…Notably, few studies have looked at effects of E 2 and P and P alone for cognitive performance in a "healthy" animal as most have used pharmacological agents or neurodegeneration models. For instance, administration of E 2 alone, or with P, to ovx rats attenuated scopolamine-induced deficits in T-maze alternations (Dohanich et al, 1994). Co-administration of E 2 and P 4 enhances performance of young oxv rats with neurodegeneration in the hippocampally-mediated spatial task (Vongher & Frye, 1999).…”

Section: Discussionmentioning

confidence: 98%

Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task

Frye

Duffy

Walf

2007

Neurobiology of Learning and Memory

218

219

View full text Add to dashboard Cite

Steroid modulation of cognitive function has focused on estrogen (E 2 ), but progestins naturally covary with E 2 and may also influence cognitive performance. Spatial performance in the object placement task over endogenous hormonal states in which E 2 and progestins vary, and when E 2 and/ or progestins were administered, was examined. Experiment 1: Rats in proestrus or estrus had significantly better performance in the object placement task than did diestrous rats. Experiment 2: Rats in the third trimester, post-partum, or lactation exhibited significantly better performance in the object placement task than did rats in the first trimester. Experiment 3: Ovariectomized (ovx) rats administered 17β-estradiol (0.9 mg/kg, subcutaneously (sc), progesterone (P; 4 mg/kg, sc), or E 2 and P, immediately after training in the object placement task, performed significantly better when tested 4 hours later, than did control rats administered vehicle (sesame oil 0.2 cc). Experiment 4: Ovx rats administered E 2 or P with a one and a half hour delay after training in the object placement task, did not perform differently than vehicle-administered controls. Experiment 5: Ovx rats administered post-training E 2 , which has a high affinity for both E 2 receptor (ER)α and β isoforms, or propyl pyrazole triol (PPT; 0.9 mg/kg, sc), which is more selective for ERα than ERβ, had significantly better performance in the object placement task than did rats administered vehicle or diarylpropionitrile (DPN; 0.9 mg/kg, sc), an ERβ selective ligand. Experiment 6: Ovx rats administered P, or its metabolite, 5α-pregnan-3α-ol-20-one (3α,5α-THP; 4 mg/kg, sc), immediately post-training performed significantly better in the object placement task than did vehicle control rats. Thus, performance in the object placement task is better when E 2 and/or P are naturally elevated or when E 2 , the ERα selective ER modulator PPT, P, or its metabolite, 3α,5α-THP, are administered post-training.

show abstract

“…For instance, cyclic estrogen replacement has been shown to significantly improve cognitive function in ovariectomized female monkeys [217]. Furthermore, estrogen replacement has been shown to improve the performance of ovariectomized rats in memory tasks such as radial mazes and water mazes [218][219][220][221][222][223][224][225], as well as in the operant alternation task [226,227] and the active avoidance task [228]. A number of studies have also provided evidence that estrogen can enhance working memory in ovariectomized animals [229][230][231][232].…”

Section: Estrogen and Memorymentioning

confidence: 99%

Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications

et al. 2007

View full text Add to dashboard Cite

Estrogen is an important hormone signal that regulates multiple tissues and functions in the body. This review focuses on the neurotrophic and neuroprotective actions of estrogen in the brain, with particular emphasis on estrogen actions in the hippocampus, cerebral cortex and striatum. Sex differences in the risk, onset and severity of neurodegenerative disease such as Alzheimer's disease, Parkinson's disease and stroke are well known, and the potential role of estrogen as a neuroprotective factor is discussed in this context. The review assimilates a complex literature that spans research in humans, non-human primates and rodent animal models and attempts to contrast and compare the findings across species where possible. Current controversies regarding the WHI (Women's Health Initiative) study, its ramifications, concerns and the new studies needed to address these concerns are also addressed. Signaling mechanisms underlying estrogen-induced neuroprotection and synaptic plasticity are reviewed, including the important concepts of genomic versus nongenomic mechanisms, types of estrogen receptor involved and their subcellular targeting, and implicated downstream signaling pathways and mediators. Finally, a multicellular mode of estrogen action in the regulation of neuronal survival and neurotrophism is discussed, as are potential future directions for the field.

show abstract

Estrogen and estrogen-progesterone treatments counteract the effect of scopolamine on reinforced T-maze alternation in female rats.

Cited by 94 publications

References 31 publications

Estradiol interacts with the cholinergic system to affect verbal memory in postmenopausal women: Evidence for the critical period hypothesis

Estradiol interacts with the cholinergic system to affect verbal memory in postmenopausal women: Evidence for the critical period hypothesis

Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task

Neurotrophic and neuroprotective actions of estrogen: Basic mechanisms and clinical implications

Contact Info

Product

Resources

About