Estrogenic activity in extracts and exudates of cyanobacteria and green algae

Sychrová, Eliška; Štěpánková, Tereza; Nováková, Kateřina; Bláha, Luděk; Giesy, John P.; Hilscherová, Klára

doi:10.1016/j.envint.2011.10.004

Cited by 56 publications

(33 citation statements)

References 42 publications

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“…It is evident that the range of health hazards presented by cyanobacteria and their metabolites is only partially understood. For example, in vitro bioassays have revealed a stimulation of mammalian estrogenic activity by cyanobacterial exudates (Sychrova et al, 2012) and a stimulation of proinflammatory responses by MC-LR; the latter effect not being attributable to the long-known inhibition of protein phosphatases by MCs (Adamovsky et al, 2015). Recognition of the roles of exposure media and routes via which cyanotoxins may present risks to human health has also been increased: one of the first risk assessments of exposure to cyanotoxins from terrestrial sources concerned potential inhalation exposure to airborne MCs from cyanobacterial desert crusts (Metcalf et al, 2012).…”

Section: Fate Impact and Health Effectsmentioning

confidence: 99%

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Toxic cyanobacteria and cyanotoxins in European waters – recent progress achieved through the CYANOCOST Action and challenges for further research

et al. 2017

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This review aims to summarise the outcomes of some recent European research concerning toxic cyanobacteria and cyanotoxins, with an emphasis on developments within the framework of the CYANOCOST Action: COST Action ES1105, Cyanobacterial Blooms and Toxins in Water Resources: Occurrence, Impacts and Management. Highlights of the Action include phycological and ecological studies, development of advanced techniques for cyanotoxin analysis, elucidation of cyanotoxin modes of action, management techniques to reduce cyanobacterial mass development, and research on methods and practices for cyanotoxin removal during drinking water treatment. The authors have identified a number of gaps in knowledge. Proposed directions for future research on toxic cyanobacteria and cyanotoxins are also discussed.

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Section: Fate Impact and Health Effectsmentioning

confidence: 99%

“…These include for example the production of endocrine-or pro-inflammatory-modulators (Sychrova et al, 2012;Adamovsky et al, 2015), and of retinoic acid receptors which cause malformations during fish embryogenesis (Kaya and Sano, 2017). Several cyanobacterial exposure routes e.g.…”

Section: Effectsmentioning

confidence: 99%

Toxic cyanobacteria and cyanotoxins in European waters – recent progress achieved through the CYANOCOST Action and challenges for further research

et al. 2017

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“…The blooms in drinking water sources and at recreational sites are of special concern and pose a threat to humans and animals (Dittmann et al 2012, Kardinaal 2007, KuiperGoodman et al 1999, Sychrova et al 2012. Some species of cyanobacteria produce metabolites that show hepatotoxic, neurotoxic, cytotoxic or dermatotoxic activities.…”

Section: Introductionmentioning

confidence: 99%

Cyanobacteria and cyanotoxins in Polish freshwater bodies

Kobos

Błaszczyk

Hohlfeld

et al. 2013

Oceanological and Hydrobiological Studies

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In this work, the authors examined the presence of cyanobacteria and cyanotoxins in 21 samples collected from fresh water bodies located in 5 provinces in Poland: Lublin (2), Podlasie (1), Pomerania (6), Warmia-Masuria (1) and Wielkopolska (11). In addition, to determine the general pattern of geographical distribution, frequency of cyanobacteria occurrence, and cyanotoxins production, the published data from 238 fresh water bodies in Poland were reviewed. On the basis of these collected results, we concluded that Planktothrix, Aphanizomenon, Microcystis and Dolichospermum were dominant. The general pattern in geographical distribution of the identified cyanobacterial genera was typical of other eutrophic waters in Europe. The production of cyanotoxins was revealed in 18 (86%) of the 21 samples analyzed in the present work and in 74 (75%) of the 98 total water bodies for which the presence of toxins had been examined. Among the 24 detected microcystin variants, [Asp 3 ]MC-RR was most common. These results can be verified when more data from the less explored water bodies in the southern and eastern parts of Poland are available.

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“…Unfortunately, most were directed at specific types of main groups of toxins, such as microcystins or cylindrospermopsin (see reviews by Singh et al, 2012 andWeller, 2013). Pioneering studies from the laboratories of Ludek Bláha and Klára Hilscherová applied reporter gene-based biosensors to evaluation of endocrine disruption potential of cyanobacterial cell components, with estrogen-like and retinoid-like activity detected (Štěpánková et al, 2011;Sychrová et al, 2012;Jonas et al, 2014Jonas et al, , 2015.…”

Section: Introductionmentioning

confidence: 97%

“…Presently, following some new reports on the activity of unknown endogenous toxic substances contained in cyanobacterial blooms (Sedmak andŠuput, 2002;Bláha et al, 2010;Štěpánková et al, 2011;Nováková et al, 2011Nováková et al, , 2012Sychrová et al, 2012), a holistic approach to water quality monitoring based on physiological effect of combined toxins and xenobiotics present in the cyanobacterial bloom seems to be a necessary complement for regulatory and monitoring purposes. Such an approach must involve the assessment of toxicity mechanisms on the organism, cellular and molecular level which are physiologically relevant to living components of the environment, especially to human health.…”

Section: Introductionmentioning

confidence: 98%