Estrogenic Alkylphenols Induce Cell Death by Inhibiting Testis Endoplasmic Reticulum Ca2+ Pumps

Hughes, Philip; McLellan, H; Lowes, Damon A.; Kahn, S Z; Bilmen, Jonathan G.; Tovey, Stephen C.; Godfrey, Rita E.; Michell, Robert H.; Kirk, Christopher J.; Michelangeli, Francesco

doi:10.1006/bbrc.2000.3710

Cited by 139 publications

(84 citation statements)

References 35 publications

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“…The results of this study showed that BPA strongly affected TM4 cell viability and morphology at concentrations of BPA over 150 M. This anomalous situation has also been discussed in previous reports. 10,20) Especially, the viability of TM4 cells decreased to about 60% of that of untreated cells after exposure to over 300 M of BPA for 16 h.…”

Section: Discussionmentioning

confidence: 98%

“…The number of mature Sertoli cells determines spermatogenesis in adult life, since one Sertoli cell can nurture only a finite number of developing sperm cells. 9,10) But there has been no reported study of overall protein alterations in cell lines exposed to BPA. In the present study, the effect of BPA on protein expression in Sertoli cells was investigated because these cells are known to provide structural and nutritional support conducive to germ cell differentiation.…”

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confidence: 99%

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Analysis of Differentially Regulated Proteins in TM4 Cells Treated with Bisphenol A

Lee

Joo

et al. 2004

Bioscience, Biotechnology, and Biochemistry

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

Analysis of Differentially Regulated Proteins in TM4 Cells Treated with Bisphenol A

Lee

Joo

et al. 2004

Bioscience, Biotechnology, and Biochemistry

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“…Hughes et al (2000), supported by the Medical Research Council, the British Heart Fund, and the European Chemical Industry Council, examined the effects of bisphenol A on rat testicular calcium pumps. Other phenolic compounds were examined, some in greater detail than bisphenol A, but this discussion is limited to bisphenol A.…”

Section: Utility (Adequacy) For Cerhr Evaluation Processmentioning

confidence: 99%

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

Chapin

Adams

Boekelheide

et al. 2008

Birth Defects Research Pt B

404

304

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“…Hughes et al [15] have proven that alkylphenol causes testicular cell death due to inhibition of endoplasmic reticulum Ca 2+ pumps. Also, it has been shown that alkylphenols containing NP cause cell death in skeletal muscle due to inhibition of sarcoplasmic reticulum Ca 2+ pumps by similar mechanisms.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Nonylphenol on Hearing in Rats

Yücedağ¹,

Okur²,

Uğuz³

et al. 2014

Int Adv Otol

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OBJECTIVE:Nonylphenol is a neurotoxic substance widely present in the environment. Although its neurotoxic effects are well-known, to our knowledge, the ototoxic effects of nonylphenol on hearing have not been published in the literature yet. We aimed to investigate the effect of nonylphenol on hearing function in rats. MATERIALS and METHODS:Fifty rats were randomly divided into five Groups each containing 10 animals. Group 1 was a control Group and Group 2 was a solvent control containing ethanol alone, whereas Groups 3, 4, and 5 were treatment Groups exposed to the different concentrations of nonylphenol dissolved in ethanol for six-weeks. Distortion product otoacoustic emission measurements were evaluated at the end of exposure. RESULTS:In the distortion product otoacoustic emission measurement, signal-to-noise ratio values did not show any statistically significant differences between the control and ethanol Groups (p>0.05). But, we found significant differences between signal-to-noise ratio values of control and nonylphenol Groups at 4000 and 6000 Hz frequencies (p<0.05). Also, we found statistically significant difference between signal-to-noise ratio values of ethanol and nonylphenol Groups at 4000 and 6000 Hz frequencies (p<0.05). There was no statistically significant difference for signal-tonoise ratio values among nonylphenol Groups (Groups 3-5) (p>0.05). CONCLUSION:Our study showed that nonylphenol has negative effects on hearing function in rats but the effects do not seem to be dose-dependent. Further studies are needed to find whether nonylphenol has an effect on hearing loss in rats as well as hearing in human beings.

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Estrogenic Alkylphenols Induce Cell Death by Inhibiting Testis Endoplasmic Reticulum Ca2+ Pumps

Cited by 139 publications

References 35 publications

Analysis of Differentially Regulated Proteins in TM4 Cells Treated with Bisphenol A

Analysis of Differentially Regulated Proteins in TM4 Cells Treated with Bisphenol A

NTP‐CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A

The Effects of Nonylphenol on Hearing in Rats

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