Estrogenization in Women with Postmenopausal Ovarian Hyperthecosis

Kemmann, Ekkehard; Orenstein, David M.; Smith, Curtis; Shelden, Robert M.; Jones, James R.

doi:10.1002/j.1879-3479.1980.tb00278.x

Cited by 5 publications

(1 citation statement)

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“…In our case, α-inhibin reacted with clusters of stromal vacuolated cells, ovarian tumor was tan-yellow in color grossly and contained oil-red-O-positive lipids in the α-inhibin-positive foamy stromal cells. Ovarian stromal hyperplasia and hyperthecosis is known to be associated with estrogenic and androgenic stimulation, and are considered to be the origin of excessive steroid hormones in the circulation [5,14]. Main source of the excess steroid hormones in ovarian stromal hyperthecosis can be proven from the marked decrease in the plasma levels of steroid hormones after ovarian wedge resection or oophorectomy [15].…”

Section: Discussionmentioning

confidence: 99%

Ovarian Endometrioid Adenocarcinoma with Functioning Stroma Accompanied with Endometrial Endometrioid Adenocarcinoma: Immunohistochemical Study and Literature Review

Yuri¹,

Mizokami²,

Kinoshita³

et al. 2013

OJPathology

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Background: The ovarian tumors with functioning stroma are defined by the morphological presence of endocrine active cells in stroma, and the clinical, biochemical or pathological evidence of endocrine function. Case Report: The ovarian endometrioid adenocarcinoma with functioning stroma accompanied with endometrial endometrioid adenocarcinoma was found in 64-year-old post-menopausal woman complaining abnormal genital bleeding and mammary distention. Her preoperative serum 17ß-estradiol level was high (53.2 pg/ml) while human chorionic gonadotropin (hCG) level was within normal limit. Her right ovary with 8.8 × 5.3 cm in size and tan-yellow in color mostly consisted of solid tumor. Histologically, tumor was composed of estrogen receptor (ER)-and progesterone receptor (PgR)-positive, and androgen receptor (AR)-negative cancerous endometrial cells with aggregates of vacuolated foamy stromal cells resembling luteinized cells. These stromal cells contained lipid droplets, and was immunopositive for α-inhibin and 17ß-estradiol. After surgery, serum 17ß-estradiol level decreased and became normal (14.2 pg/ml). These findings indicate the production of steroid hormone (17ß-estradiol) from the foamy stromal cells and may be correlated with the clinical symptoms. Furthermore, ER-and PgR-positive endometrial endometrioid adenocarcinoma developed synchronously. However, ovary and uterus were totally immunonegative for human chorionic gonadotropin (hCG). Four other cases from the literature including ours are reviewed. Conclusion: Cancer cells were positive for ER and PgR in both ovary and uterus responded to steroid hormone produced by foamy stromal cells, which played a role in proliferation and progression of ovarian and endometrial endometrioid adenocarcinoma, respectively.

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Section: Discussionmentioning

confidence: 99%