Estrogens down-regulate the stem cell factor (SCF)/c-KIT system in prostate cells: Evidence of antiproliferative and proapoptotic effects

The protective effect of regucalcin against radiation-induced damage in testicular cells

“…Therefore, the enzymatic activity of caspase-3 has been widely used to measure apoptosis [12,40,44].…”

Is Normal Kidney Cells Viability Influenced by Estradiol Valerate Administration in Cell Culture?

“…The results also has demonstrated that E2 down-regulates the expression of SCF/c-KIT system in prostate cells, which is associated with antiproliferative and proapoptotic effects. [12] Exposure to corticosteroids decreased mesenchymal stem cells viability in a curvilinear dose-response pattern. [13] Steroidal molecules also play an important role in determining the fate of mesenchymal stem cells, mainly by altering the expression of key cellular molecules.…”

“…Since sex steroids such as estrogens are important hormonal drugs in the world [9] and also in Iran [11] and according to the side effects caused by many drugs [12] and costly treatment imposed on patients with cancer [13] and conflicting data on the effects of sex steroids on cancer cells [4], [7 ], this study was carried out to determine the effects of aspirin on viability of normal kidney cells in cell culture. …”

“…In contrast, Some Studies show that some of sex steroids have a protective role counteracting prostate overgrowth [7].…”

The effect of mast cells on the biological characteristics of prostate cancer cells

“…The signalling pathway of proliferation and differentiation of PCa cells was closely related to c-kit [ 14 ]. Stem cell factor (SFC) was found in the 1990s, as kit ligand [ 15 ], mast cell growth factor [ 16 ], and stem cell factor [ 17 ], now known as stem cell factor. Consistent with this, in this study, by QRT-PCR assay and western blot experiments, the mRNA and protein expression of SCF and c-kit in the experimental group was significantly higher than that seen in the control group, and the difference was statistically significant ( p < 0.05).…”