Cognitive Fusion is related to psychological problems, such as anxiety and depression, and is assessed through the Cognitive Fusion Questionnaire (CFQ). Aim: to confirm the unidimensional structure of the CFQ, its internal consistency reliability, and convergent and divergent validity in a sample of Ecuadorian college students. Method: instrumental design using Confirmatory Factor Analysis (CFA) and Structural Equation Modeling (SEM) to estimate convergent and divergent validity of the CFQ. Participants: 356 college students (59.1% women) aged between 18 and 58 years (M = 25.52, SD = 7.51) from several universities in Ecuador (43.9% public institutions). Results: the unidimensional structure of the CFQ is confirmed, through adequate fit indices. Its reliability is excellent (ω = .954) and, regarding convergent and divergent validity, it correlates positively with Experiential Avoidance (AAQ-II) and negatively with Satisfaction with Life (SWLS). Conclusion: The Psychometric properties of the CFQ are adequate for its application in Ecuadorian college students.