Ethanol Enhances De Novo Synthesis of High Density Lipoprotein Cholesterol

Cluette, Joanne E.; Mulligan, John J.; Noring, Richard; Doyle, Kathleen M.; Hojnacki, Jerome L.

doi:10.3181/00379727-176-4-rc2

Cited by 14 publications

(3 citation statements)

References 4 publications

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“…42 Moderate alcohol consumption raises the levels of both HDL-C and apo A-l 2 0 2 2 probably because of enhanced hepatic synthesis and secretion. 43 Adolescents consuming alcohol in the current study showed consistently higher levels of both HDL-C and apo A-l. Although alcohol intake (ml/week) and the number of weekly cigarettes are interrelated (r = 0.15 in the present study), persons who smoked cigarettes showed decreased levels of both HDL-C and apo A-l independently of alcohol intake.…”

Section: Discussionsupporting

confidence: 46%

Correlates of high density lipoprotein cholesterol and apolipoprotein A-I levels in children. The Bogalusa Heart Study.

Freedman¹,

Srinivasan²,

Shear³

et al. 1987

Arteriosclerosis

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Section: Discussionsupporting

confidence: 46%

Correlates of high density lipoprotein cholesterol and apolipoprotein A-I levels in children. The Bogalusa Heart Study.

Freedman¹,

Srinivasan²,

Shear³

et al. 1987

Arteriosclerosis

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“…Despite nearly similar prevalences of the metabolic syndrome, the AFLD group had significantly higher HDL cholesterol and higher triglycerides than the NAFLD group (Additional file 1). In the face of otherwise matched groups, these lipid differences are likely to be due to alcohol, which is known to increase both HDL cholesterol and triglyceride concentrations [23,24]. Diastolic blood pressure was also significantly higher in AFLD than in NAFLD, which could also be due to alcohol use independent of obesity and insulin [25].…”

Section: Discussionmentioning

confidence: 99%

Non-alcoholic and alcoholic Fatty Liver Disease - two Diseases of Affluence associated with the Metabolic Syndrome and Type 2 Diabetes: the FIN-D2D Survey

et al. 2010

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BackgroundNon-alcoholic fatty liver disease (NAFLD) is known to be associated with the metabolic syndrome (MetS) and abnormal glucose tolerance. Whether alcoholic fatty liver disease (AFLD) is associated with similar metabolic abnormalities has not been examined in a population-based study. We aimed at assessing the prevalences of NAFLD and AFLD, and to examine to what extent these conditions are associated with MetS and abnormal glucose tolerance.MethodsThe cohort included 2766 Finnish subjects (45-74 years) from the population-based FIN-D2D survey. Features of insulin resistance, components of the MetS, glucose tolerance status by oral glucose tolerance test, serum liver enzyme concentrations, and daily alcohol consumption were assessed.ResultsSubjects with NAFLD and AFLD were equally obese and had similar fasting and insulin concentrations. The prevalences of NAFLD and AFLD were 21% (95% CI: 19%-22%) and 7% (95% CI: 6%-8%). The MetS was slightly more prevalent in AFLD (73%) than in NAFLD (70%, p = 0.028), and type 2 diabetes was similarly prevalent in NAFLD and AFLD (24-25%). The MetS and type 2 diabetes were more prevalent in subjects with NAFLD or AFLD compared to subjects with normal LFTs (53% and 14%, p < 0.0001 for both).Discussion and conclusionIn Finnish middle-aged population, the prevalence of NAFLD is 3-fold higher than that of AFLD. The prevalences of MetS and type 2 diabetes are, however, significantly increased in both NAFLD and AFLD compared to subjects with normal LFTs. Subjects with AFLD are thus similarly metabolically unhealthy as subjects with NAFLD.

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“…Early studies in rats that were chronically treated with ethanol found an elevation in serum cholesterol bound to high density lipoprotein (HDL) [Hirayama et al 1979]. These increases were later shown to be due to de novo synthesis of HDL [Cluette et al 1984] and were found in humans as well [McConnell et al 1997;Dai et al 1985]. In addition to elevated HDL levels, chronic ethanol consumption decreased LDL levels [Langer et al 1992;Taskinen et al 1987].…”

Section: Threshold Lethalmentioning

confidence: 99%

Ethanol for cardiac ischemia: the role of protein kinase c

Churchill

Disatnik

Budas

et al. 2008

Therapeutic Advances in Cardiovascular Disease

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The physiological effects of ethanol are dependent upon the amount and duration of consumption. Chronic excessive consumption can lead to diseases such as liver cirrhosis, and cardiac arrhythmias, while chronic moderate consumption can have therapeutic effects on the cardiovascular system. Recently, it has also been observed that acute administration of ethanol to animals prior to an ischemic event provides significant protection to the heart. This review focuses on the different modalities of chronic vs. acute ethanol consumption and discusses recent evidence for a protective effect of acute ethanol exposure and the possible use of ethanol as a therapeutic agent.

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Ethanol Enhances De Novo Synthesis of High Density Lipoprotein Cholesterol

Abstract: Male squirrel monkeys fed ethanol at variable doses were used to assess whether alcohol enhances de novo synthesis of high density lipoprotein (HDL) cholesterol in vivo. Monkeys were divided

Cited by 14 publications

References 4 publications

Correlates of high density lipoprotein cholesterol and apolipoprotein A-I levels in children. The Bogalusa Heart Study.

Correlates of high density lipoprotein cholesterol and apolipoprotein A-I levels in children. The Bogalusa Heart Study.

Non-alcoholic and alcoholic Fatty Liver Disease - two Diseases of Affluence associated with the Metabolic Syndrome and Type 2 Diabetes: the FIN-D2D Survey

Ethanol for cardiac ischemia: the role of protein kinase c

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