The separation of organic molecules
in downstream processes, such
as distillation, plays a vital role in biobased chemical production.
A comprehensive study was performed here using ultrasonic energy to
separate 11 organic molecules from their binary aqueous solutions
under nonthermal, nonequilibrium, and phase-change free conditions.
A batch sonoseparator with a three-stage mist collection unit allowed
direct analysis of ultrasound-generated mist with an HPLC/GC and differentiation
and quantification of the vapor and mist. The results showed that
the alcohols (1-butanol, ethanol, 1-propanol, and methanol) and acetone
were enriched in the ultrasound-generated mist with enrichment ratios
of 3.2–5. On the other hand, ethylene glycol, glycerol, γ-valerolactone
(GVL), glucose, and sucrose were diluted with dilution ratios in the
range of 2.04–15.7 in the mist and vapor generated by ultrasound
(or concentrated in the bulk solution). No enrichment nor dilution
of acetic acid was observed. The role of various physicochemical parameters
such as dynamic viscosity, surface tension, Henry’s law of
solubility constant, vapor pressure, and octanol–water partition
coefficient in the enrichment was examined. The hydrophobicity of
the organic molecules represented by the octanol–water partition
coefficient was found to play a crucial role in determining the separation
characteristics of the molecules in ultrasound-generated mist and
vapor.