Ethanol extract from Moringa oleifera leaves modulates brown adipose tissue and bone morphogenetic protein 7 in high-fat diet mice

Syamsunarno, Mas Rizky Anggun Adipurna; Alia, Fenty; Anggraeni, Neni; Sumirat, Vanessa Ayu; Praptama, Suhendra; Atik, Nur

doi:10.14202/vetworld.2021.1234-1240

Cited by 8 publications

(19 citation statements)

References 42 publications

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“…In recent years, some studies have shown that extracts from M. oliefera leaves could regulate lipid metabolism. For example, Syamsunarno et al ( 43 ) explored the effects of ethanol extract from M. oleifera leaves on modulating brown adipose tissue differentiation in mice fed an HFD. Mabrouki et al ( 44 ) evaluated the effect of the methanolic extract of M. oleifera leaves on HFD-induced obesity and cardiac damage in rats.…”

Section: Discussionmentioning

confidence: 99%

“…Our team has also investigated M. oleifera leaf petroleum ether extract inhibits lipogenesis ( 46 ). In these studies, the main components of M. oleifera leaf extracts were phenolic compounds ( 44 ) and flavonoid glycosides ( 46 ), without even elucidating their main components ( 43 , 45 ). Therefore, the activity of MOP in regulating lipid metabolism is currently unclear.…”

Section: Discussionmentioning

confidence: 99%

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Crude Polysaccharide Extracted From Moringa oleifera Leaves Prevents Obesity in Association With Modulating Gut Microbiota in High-Fat Diet-Fed Mice

Wen

et al. 2022

Front. Nutr.

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Moringa oleifera is a commonly used plant with high nutritional and medicinal values. M. oleifera leaves are considered a new food resource in China. However, the biological activities of M. oleifera polysaccharides (MOP) in regulating gut microbiota and alleviating obesity remain obscure. In the present study, we prepared the MOP and evaluated its effects on obesity and gut microbiota in high-fat diet (HFD)-induced C57BL/6J mice. The experimental mice were supplemented with a normal chow diet (NCD group), a high-fat diet (HFD group), and HFD along with MOP at a different dose of 100, 200, and 400 mg/kg/d, respectively. Physiological, histological, biochemical parameters, genes related to lipid metabolism, and gut microbiota composition were compared among five experimental groups. The results showed that MOP supplementation effectively prevented weight gain and lipid accumulation induced by HFD, ameliorated blood lipid levels and insulin resistance, alleviated the secretion of pro-inflammatory cytokines, and regulated the expression of genes related to lipid metabolism and bile acid metabolism. In addition, MOP positively reshaped the gut microbiota composition, significantly increasing the abundance of Bacteroides, norank_f_Ruminococcaceae, and Oscillibacter, while decreasing the relative abundance of Blautia, Alistipes, and Tyzzerella, which are closely associated with obesity. These results demonstrated that MOP supplementation has a protective effect against HFD-induced obesity in mice, which was associated with reshaping the gut microbiota. To the best of our knowledge, this is the first report on the potential of MOP to prevent obesity and modulating gut microbiota, which suggests that MOP can be used as a potential prebiotic.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Crude Polysaccharide Extracted From Moringa oleifera Leaves Prevents Obesity in Association With Modulating Gut Microbiota in High-Fat Diet-Fed Mice

Wen

et al. 2022

Front. Nutr.

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“…This study suggested that flavonoids found in MO could modulate the BMP7 expression. However, this study did not provide phytochemical analysis, but they proposed that flavonoids were responsible for the mechanisms ( Syamsunarno et al, 2021 ). These data were supported by an in vitro study that used human adipose-derived mesenchymal stem cells to investigate the effect of MO on lipids metabolism and antioxidant systems related to the adipogenesis process ( Barbagallo et al, 2016 ).…”

Section: Role Of Mo In Cardiovascular Diseasesmentioning

confidence: 87%

“…MO is traditionally consumed in raw materials, such as fresh leaves or leaves powder, manufactured commercially by the community ( Syamsunarno et al, 2021 ). These preparations are also applied in various human studies and become a challenge in implementing studies that use oral administration methods due to the unpleasant odor and intolerable taste of MO leaves.…”

Section: Limitations and Recommendation For Future Researchmentioning

confidence: 99%

The Potency of Moringa oleifera Lam. as Protective Agent in Cardiac Damage and Vascular Dysfunction

et al. 2022

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Cardiac damage and vascular dysfunction due to underlying diseases, such as hypertension and cardiac thrombosis, or side effects from certain drugs may lead to critical illness conditions and even death. The phytochemical compounds in natural products are being prospected to protect the heart and vascular system from further damage. Moringa genus is a subtropical tree native to Asia and Africa, which includes 13 species; Moringa oleifera Lam. (MO) is the most cultivated for its beneficial uses. MO is also known as the “miracle tree” because it has been used traditionally as a food source and medicine to treat various diseases such as anemia, diabetes, and infectious or cardiovascular diseases. The phytochemical compounds identified in MO with functional activities associated with cardiovascular diseases are N,α-L-rhamnopyranosyl vincosamide, isoquercetin, quercetin, quercetrin, and isothiocyanate. This study aims to investigate the potency of the phytochemical compounds in MO as a protective agent to cardiac damage and vascular dysfunction in the cardiovascular disease model. This is a scoping review by studying publications from the reputed database that assessed the functional activities of MO, which contribute to the improvement of cardiac and vascular dysfunctions. Studies show that the phytochemical compounds, for example, N,α-L-rhamnopyranosyl vincosamide and quercetin, have the molecular function of antioxidant, anti-inflammation, and anti-apoptosis. These lead to improving cardiac contractility and protecting cardiac structural integrity from damage. These compounds also act as natural vasorelaxants and endothelium protective agents. Most of the studies were conducted on in vivo studies; therefore, further studies should be applied in a clinical setting.

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“…Coagulant protein isolated from MO possessed a great antimicrobial action against many isolates of bacteria isolated from water [195]. Leaf extract could modulate the diferentiation of brown adipose tissue through the upregulation of bone morphogenetic protein 7 (BMP7) levels in obese mice [196]. Te ethanolic extracts were associated with signifcant normalization of proteins of antioxidant, antiinfammatory, and antiapoptotic activities [197].…”

Section: Moringa Oleifera and Proteinsmentioning

confidence: 99%

Moringa oleifera: Recent Insights for Its Biochemical and Medicinal Applications

Abdelazim,

Afifi,

Abu-Alghayth

et al. 2024

Journal of Food Biochemistry

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Plants could be used for multiple medicinal purposes. Moringa oleifera (MO) is considered the most famous plant used for this purpose. The present review aimed to spot the light on the recent medicinal, biochemical, and nutritional applications of MO. The plant contains a huge number of nutrients such as fatty acids, amino acids, proteins, polysaccharides, minerals, and vitamins. It has been used to control glucose, lipids, proteins, minerals, vitamins, hormones, and antioxidants in many animals and human models. Its medicinal applications are also varied and wide; it could be used to control and manage lots of disorders. Extracts and isolated ingredients from the plant open the way for many researchers all over the world to study its biochemical and medicinal impact on many experimental and clinical models. The present review spots the light on the recent medicinal and biochemical significance of MO opening the discussion and demonstrating the strengths and weaknesses in the MO research area. Regardless of the contrary concept, we considered MO a promising plant that could be studied for its medicinal applications on both biochemical and molecular levels. We recommended further research on the molecular effects of MO in healthy and diseased models.

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Ethanol extract from Moringa oleifera leaves modulates brown adipose tissue and bone morphogenetic protein 7 in high-fat diet mice

Cited by 8 publications

References 42 publications

Crude Polysaccharide Extracted From Moringa oleifera Leaves Prevents Obesity in Association With Modulating Gut Microbiota in High-Fat Diet-Fed Mice

Crude Polysaccharide Extracted From Moringa oleifera Leaves Prevents Obesity in Association With Modulating Gut Microbiota in High-Fat Diet-Fed Mice

The Potency of Moringa oleifera Lam. as Protective Agent in Cardiac Damage and Vascular Dysfunction

Moringa oleifera: Recent Insights for Its Biochemical and Medicinal Applications

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