Ethanol Extract of Brassica Rapa Attenuate the Complete Freund’s Adjuvant-Induced Inflammation in Rats

Abstract

Turnip is an ancient edible plant belongs to family Braaicacaceae. Traditionally it is used for the treatment of various disorders such as diabetes, hepatotoxicity, ulcer, and anti-inflammatory activity. Therefore the current investigation was attempted to investigate the anti-inflammatory activity of Brassica rapa root extract against complete fluids adjuvant induced inflammation in experimental animals. The Ethanol extract of Brassica rapa was prepared by a hot extraction procedure and phytochemical analysis of different extract was done by different chemical tests. Daily oral treatment of indomethacin, and extract for twenty-one days after three days of CFA administration significantly decrease the paw volume, hepatic biomarkers as well as ameliorated the level of a hematological parameter such as hemoglobin, RBC, WBC, ESR and bodyweight of experimental animals. From the result of the current investigation, it can be concluded that the Brassica rapa extract possesses anti-inflammatory activity. Further study is required to explore the mechanism responsible for its anti-inflammatory activity.

Preclinical Assessment of Aceclofenac Transdermal Patch by Freund’s Complete Adjuvant-induced Arthritis in Rats

“…The anti-arthritic activity of the ACF-loaded patch P13 was evaluated in Wistar albino rats by using Freund's complete adjuvant (FCA) induced arthritis model. 9 Each rat in the groups was placed in an observation chamber for 10-15 minutes to minimize the stress-related behaviors. Arthritis was induced in all groups of animals excluding naive control, with 0.1 mL of complete Freund's adjuvant in the right hind paw.…”

Inter-Varietal Variation in Phenolic Profile, Antioxidant, Anti-Inflammatory and Analgesic Activities of Two Brassica rapa Varieties: Influence on Pro-Inflammatory Mediators

“…Inflammation is the main protective response of the primary immune system against damage and is characterized by both acute and chronic inflammations [ 1 , 2 ]. Acute inflammation results in the formation of edema, leukocyte infiltration, and macrophage infiltration in the damaged muscle [ 3 ].…”

“…Certain dietary polyphenols such as quercetin and catechin are natural antioxidants and exhibit the effect of balancing the generation of pro- and anti-inflammatory cytokines, and increase IL-10 secretion while inhibiting TNF-α [ 10 , 11 ]. Thus, anti-inflammatory drugs derived from natural sources and used in traditional medicine have attracted the attention of health professionals and the pharmaceutical industry due to their effectiveness and fewer side effects [ 1 , 2 , 4 ]. Polyphenols are a class of natural compounds that are under consideration due to many reasons [ 8 , 12 , 13 ].…”

“…B. rapa is a rich source of bioactive compounds including isothiocyanates, glucosinolates, anthocyanins, carotenoids, flavonoids, sulforaphane, organic acids and phenolic compounds [ 17 , 18 ]. The whole plant has been used not only for nourishment, but also as a traditional remedy against several diseases, including inflammation [ 2 ]. B. rapa ethanol extract has been reported to display an anti-arthritis effect against complete Freund’s adjuvant-induced inflammation and exhibits incredible anti-inflammatory effect and analgesic potential [ 2 , 19 ].…”

“…The whole plant has been used not only for nourishment, but also as a traditional remedy against several diseases, including inflammation [ 2 ]. B. rapa ethanol extract has been reported to display an anti-arthritis effect against complete Freund’s adjuvant-induced inflammation and exhibits incredible anti-inflammatory effect and analgesic potential [ 2 , 19 ].…”