Ethanol Reduces Amyloid Aggregation In Vitro and Prevents Toxicity in Cell Lines

Ormeño, David; Romero, Fernando; Fenner, Julio López; Ávila, Andrés I.; Martı́nez-Torres, Ataúlfo; Parodí, Jorge

doi:10.1016/j.arcmed.2012.12.004

Cited by 26 publications

(26 citation statements)

References 52 publications

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“…Bate et al [62] reported that low concentrations of ethanol (0.02-0.08%) partially protect cultured cortical and hippocampal neurons against the Aβ-induced synapse toxicity. The results are similar to another observation that low concentrations of ethanol protect against damage induced by Aβ in primary neuronal cultures [30,31] and cell lines [32]. Moreover, they found that after consuming 6% ethanol for 2 months, the learning and memory abilities in 3xTg-AD mice were improved [30].…”

Section: Studies In Animal and Cell Culture Modelssupporting

confidence: 88%

“…Higher concentrations of ethanol contribute to increased accumulation/production of Aβ and the precursor protein [34]. One recent study showed that alcohol drinking in the show that low or moderate concentrations of ethanol reduce the damage induced by β-amyloid (Aβ) in AD [30][31][32][33]. Higher concentrations of ethanol contribute to increased accumulation/production of Aβ and the precursor protein [34].…”

Section: Introduction and Alcohol Use: Dual Effects And Mechanismsmentioning

confidence: 99%

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Role of Alcohol Drinking in Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis

Peng

Yang²,

Joshi

et al. 2020

IJMS

103

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Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS), increase as the population ages around the world. Environmental factors also play an important role in most cases. Alcohol consumption exists extensively and it acts as one of the environmental factors that promotes these neurodegenerative diseases. The brain is a major target for the actions of alcohol, and heavy alcohol consumption has long been associated with brain damage. Chronic alcohol intake leads to elevated glutamate-induced excitotoxicity, oxidative stress and permanent neuronal damage associated with malnutrition. The relationship and contributing mechanisms of alcohol with these three diseases are different. Epidemiological studies have reported a reduction in the prevalence of Alzheimer’s disease in individuals who drink low amounts of alcohol; low or moderate concentrations of ethanol protect against β-amyloid (Aβ) toxicity in hippocampal neurons; and excessive amounts of ethanol increase accumulation of Aβ and Tau phosphorylation. Alcohol has been suggested to be either protective of, or not associated with, PD. However, experimental animal studies indicate that chronic heavy alcohol consumption may have dopamine neurotoxic effects through the induction of Cytochrome P450 2E1 (CYP2E1) and an increase in the amount of α-Synuclein (αSYN) relevant to PD. The findings on the association between alcohol consumption and ALS are inconsistent; a recent population-based study suggests that alcohol drinking seems to not influence the risk of developing ALS. Additional research is needed to clarify the potential etiological involvement of alcohol intake in causing or resulting in major neurodegenerative diseases, which will eventually lead to potential therapeutics against these alcoholic neurodegenerative diseases.

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Section: Studies In Animal and Cell Culture Modelssupporting

confidence: 88%

Section: Introduction and Alcohol Use: Dual Effects And Mechanismsmentioning

confidence: 99%

Role of Alcohol Drinking in Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis

Peng

Yang²,

Joshi

et al. 2020

IJMS

103

View full text Add to dashboard Cite

show abstract

“…However, a number of interesting studies have indicated a beneficial effect of light to moderate alcohol consumption, regardless of the type of beverage, on incident dementia and the development of Alzheimer disease (Anstey et al., ; Letenneur, ; Neafsey and Collins, ; Solfrizzi et al., ; Weyerer et al., ). Alzheimer disease features the accumulation of a specific form of amyloid, and experimentally, EtOH in vitro protects cells against the formation of stable multimers of amyloid molecules (Ormeno et al., ).…”

Section: Dementiamentioning

confidence: 99%

To Drink or Not to Drink: That Is the Question

Rubin

2014

Alcoholism Clin & Exp Res

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“…Several human studies have reported that moderate alcohol intake is associated with a lower risk of Alzheimer disease (AD) dementia [3,[9][10][11][12][13]. Neurobiological findings from animal and cell culture models have demonstrated that moderate alcohol intake confers protection by attenuating molecular amyloid-beta (Aβ) pathology and blocking Aβ-induced damage [17][18][19][20]. Moderate alcohol intake decreased Aβ peptides in AD transgenic mice by promoting the non-amyloidogenic processing of amyloid precursor protein [17].…”

Section: Introductionmentioning

confidence: 99%

Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study

Kim

Byun

et al. 2020

PLoS Med

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Background An emerging body of literature has indicated that moderate alcohol intake may be protective against Alzheimer disease (AD) dementia. However, little information is available regarding whether moderate alcohol intake is related to reductions in amyloid-beta (Aβ) deposition, or is protective via amyloid-independent mechanisms in the living human brain. Here we examined the associations of moderate alcohol intake with in vivo AD pathologies, including cerebral Aβ deposition, neurodegeneration of AD-signature regions, and cerebral white matter hyperintensities (WMHs) in the living human brain.

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Ethanol Reduces Amyloid Aggregation In Vitro and Prevents Toxicity in Cell Lines

Cited by 26 publications

References 52 publications

Role of Alcohol Drinking in Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis

Role of Alcohol Drinking in Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis

To Drink or Not to Drink: That Is the Question

Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study

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