Ethno-pharmacological insulin signaling induction of aqueous extract of Syzygium paniculatum fruits in a high-fat diet induced hepatic insulin resistance

Konda, Prabhakar Yellanur; Chennupati, Vidyasagar; Dasari, Sreenivasulu; Sharma, Nidhi; Muthulingam, Muthukumaran; Ramakrishnan, Ranjani; Ankanna, S.; Jagadheeshkumar, Vigneshwari; Vijayakumar, Natesan; Jaiswal, Krishna Kumar

doi:10.1016/j.jep.2020.113576

Cited by 11 publications

(3 citation statements)

References 37 publications

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“…To stabilize and improve the bioavailability of the drug molecules, NE as a delivery system can be a suitable approach for solving these issues (Akhtar et al, 2016;Nanjwade et al, 2013). Several in vitro and in vivo studies have reported the antidiabetic activity of biologically active herbal formulations from Mentha aquatica, Syzygium paniculatum Gaertn, pectinase -treated probiotic banana juice, Persea americana, Mangifera indica, to name a few for the treatment of hyperglycemia conditions (Konda et al, 2020(Konda et al, , 2021Ojo et al, 2022;Sudha Madhuri & Mohanvelu, 2017;Yellanur et al, 2020). Therefore, NE as a delivery vehicle can be applied to these novel phytocompounds to enhance their effectiveness and biopharmaceutical properties.…”

Section: Eos Ofmentioning

confidence: 99%

Plant‐based essential oil encapsulated in nanoemulsions and their enhanced therapeutic applications: An overview

Jamir,

Bhushan,

Sanjukta

et al. 2023

Biotech & Bioengineering

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In recent years, studies on the formulation of nanoemulsions have been the focus of attention due to their potential applicability in food, pharmaceuticals, cosmetics, and agricultural industries. Nanoemulsions can be formulated using ingredients approved by the Food and Drug Administration (FDA), which assures their safety profiles to a great extent. Bioactive compounds such as essential oils although have strong biological properties and antimicrobial compounds, their usage is restricted due to their high volatility, instability, and hydrophobic nature. Therefore, nanoemulsion as carrier vehicle can be used to encapsulate essential oils to obtain stable and enhanced physicochemical characteristics of the essential oils. This review details the structure, formulation, and characterization techniques used for nanoemulsions, with a focus on the essential oil‐based nanoemulsions which have the potential to be used as antimicrobial and anticancer therapeutics.

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Section: Eos Ofmentioning

confidence: 99%

Plant‐based essential oil encapsulated in nanoemulsions and their enhanced therapeutic applications: An overview

Jamir,

Bhushan,

Sanjukta

et al. 2023

Biotech & Bioengineering

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“…Myricitrin isolated from the S. malaccense leaf extract exhibited insulin-like effects by enhancing lipid accumulation, glucose uptake, and adiponectin secretion via the activation of the insulin signaling pathway [ 58 ]. The aqueous extract of Syzygium paniculatum fruits alleviated hepatic insulin resistance at a 100 mg/kg dose by reducing the blockage of the insulin signaling pathway via the improvement of insulin receptor (IR and IRS-1) function in HFD-induced diabetic rats [ 59 ]. In addition, the IR mRNA levels were restored to the control level in type-2 diabetic rats treated with Syzygium jambolanum homeopathic remedies, suggesting improvement in insulin secretion [ 60 ].…”

Section: Neuroprotective Agents From Syzygiummentioning

confidence: 99%

Roles of Syzygium in Anti-Cholinesterase, Anti-Diabetic, Anti-Inflammatory, and Antioxidant: From Alzheimer’s Perspective

Rawa

Mazlan

Ahmad

et al. 2022

Plants

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Alzheimer’s disease (AD) causes progressive memory loss and cognitive dysfunction. It is triggered by multifaceted burdens such as cholinergic toxicity, insulin resistance, neuroinflammation, and oxidative stress. Syzygium plants are ethnomedicinally used in treating inflammation, diabetes, as well as memory impairment. They are rich in antioxidant phenolic compounds, which can be multi-target neuroprotective agents against AD. This review attempts to review the pharmacological importance of the Syzygium genus in neuroprotection, focusing on anti-cholinesterase, anti-diabetic, anti-inflammatory, and antioxidant properties. Articles published in bibliographic databases within recent years relevant to neuroprotection were reviewed. About 10 species were examined for their anti-cholinesterase capacity. Most studies were conducted in the form of extracts rather than compounds. Syzygium aromaticum (particularly its essential oil and eugenol component) represents the most studied species owing to its economic significance in food and therapy. The molecular mechanisms of Syzygium species in neuroprotection include the inhibition of AChE to correct cholinergic transmission, suppression of pro-inflammatory mediators, oxidative stress markers, RIS production, enhancement of antioxidant enzymes, the restoration of brain ions homeostasis, the inhibition of microglial invasion, the modulation of ß-cell insulin release, the enhancement of lipid accumulation, glucose uptake, and adiponectin secretion via the activation of the insulin signaling pathway. Additional efforts are warranted to explore less studied species, including the Australian and Western Syzygium species. The effectiveness of the Syzygium genus in neuroprotective responses is markedly established, but further compound isolation, in silico, and clinical studies are demanded.

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“…17,18 To date, a number of preclinical studies have demonstrated the ameliorative bioactive effects of lilly pilly extract in the context of diabetes mellitus. 19,20 This narrow scope highlights the need to explore the broader bioactive properties of Syzygium paniculatum . Furthermore, the polyphenol content of these fruits has not been extensively characterised.…”

Section: Introductionmentioning

confidence: 99%

Polyphenol characterisation and diverse bioactivities of native Australian lilly pilly (Syzygium paniculatum) extract

Pachulicz

Jovcevski

et al. 2022

Food Funct.

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Ethno-pharmacological insulin signaling induction of aqueous extract of Syzygium paniculatum fruits in a high-fat diet induced hepatic insulin resistance

Cited by 11 publications

References 37 publications

Plant‐based essential oil encapsulated in nanoemulsions and their enhanced therapeutic applications: An overview

Plant‐based essential oil encapsulated in nanoemulsions and their enhanced therapeutic applications: An overview

Roles of Syzygium in Anti-Cholinesterase, Anti-Diabetic, Anti-Inflammatory, and Antioxidant: From Alzheimer’s Perspective

Polyphenol characterisation and diverse bioactivities of native Australian lilly pilly (Syzygium paniculatum) extract

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