Ethnobotanical survey and cytotoxicity testing of plants of South-western Nigeria used to treat cancer, with isolation of cytotoxic constituents from Cajanus cajan Millsp. leaves

Ashidi, J. S.; Houghton, Peter J.; Hylands, Peter J.; Efferth, Thomas

doi:10.1016/j.jep.2010.01.009

Cited by 155 publications

(97 citation statements)

References 31 publications

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“…The glycolytic enzymes GAPDH are responsible for ATP production and have been reported to be vital for the survival of Trypanosomatids. 140,141 From the stem bark of Vernonia guineensis (Asteraceae), vernoguinosterol (60) and vernoguinoside (61), exhibited interesting trypanocidal activity with IC50 values in the range 4.60 -7.67 μM. …”

Section: Triterpenoidsmentioning

confidence: 99%

“…This might explain why about 80% of the population tends to rely on medicinal plants as a primary source of healthcare. [55][56][57][58][59][60][61][62][63][64][65][66][67] It is our goal to provide evidence of the efficacy and potency of plants used in traditional medicine against protozoal infections. The systematic documentation of the plant-based chemical constituents of African traditional medicine and attempting to using in silico procedures to investigate their modes of action are ongoing efforts, [44][45][46]52,53 particularly on the isolated compounds from African medicinal plants (AMPs) with evaluated in vitro and/or in vivo activities against trypanosomiasis, [68][69][70][71][72][73][74] schistosomiasis, leishmaniasis 73,74 and other parasitic protozoal diseases.…”

Section: Introductionmentioning

confidence: 99%

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Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Cv¹,

Ntie‐Kang²,

Sh.³

et al. 2018

Preprint

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An absolute configuration of 5R seems to decrease activity of the compound IntroductionProtozoa may be considered as microscopic, essentially single-celled, eukaryotic organisms that are free-living or parasitic (obtaining their food by eating other organisms or their products) in nature. Parasitic protozoal diseases continue to be a cause of considerable morbidity and mortality globally. 1,2Parasitic protozoal diseases include malaria, 3,4 trypanosomiasis (African sleeping sickness and Chagas disease), 5-7 leishmaniasis 8 and schistosomiasis. 9,10 They threaten almost one-third of the world's population, the most numerous incidents being recorded in over 100 Tropical and developing countries and territories, Figure 1. 11,12 Malaria, for example, was reported by the WHO, to be responsible for approximately 214 million sickness cases and 438,000 deaths globally in 2017. 13 The African region recorded the most death-related cases, especially amongst infants below the age of 5 and pregnant women. Schistosomiasis, caused by parasites of the Schistosoma genus are responsible for about 200 million sickness cases and about 280,000 death-related incidents annually worldwide.9,10,14 Only one drug (praziquantel) has been proven to be effective in the treatment of human schistosomiasis, with no vaccine available or in development so far.15-21 Serious concerns about drug selectivity and resistance were raised in 2013 when over 30 million people were treated in Sub-Saharan Africa. 20 Moreover, observed resistance and reduced efficiency of praziquantel in laboratory strains have prompted the search for alternative therapeutic strategies. Trypanosomiasis, which represents several diseases caused by parasites of the genus Trypanosoma, is also of interest. 5,27,29 This disease, which is much arguably the most important disease of man and domesticated animals, accounts for over 8 million reported annual cases globally, especially in the tropical regions of Latin America and Africa. 30,31 Although the present number of cases seems negligible on a worldwide scale, great socioeconomic effects on the endemic areas by this disease are forecast if inadequate attention (both at the communal, national, and international levels) is not given. 7,29,[32][33][34] Leishmaniasis is caused by parasites of the Leishmania type, which is also transmitted by certain types of sandflies. 35,36 The diseases are reported by the WHO to be responsible for about 1 million new cases leading to approximately 30,000 deaths annually on a global scale. The major cause is linked to environmental changes A R T I C L E I N F O A B S T R A C TArticle history:English abstract: Parasitic diseases continue represent a threat on a global scale, particularly among the poorest countries in the world. This is particularly because of the absence of vaccines, and in some cases, resistance against available drugs, currently being used for their treatment. In this review emphasis is laid on natural products and scaffolds from African medicinal plants (AMPs) for lead drug di...

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Section: Triterpenoidsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Cv¹,

Ntie‐Kang²,

Sh.³

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…The percent cell viability was calculated by dividing the average absorbance of the cells treated with the test compounds by that of the control; % cell viability was plotted against drug concentration (logarithmic scale) to determine the IC 50 (drug concentration at which 50% of the cells are viable relativeto the control), with the error estimated from the average of 3 trials. For the use of XTT solution the experimental procedure was followed as described in the literature [31].…”

Section: [Ru(dppb)(spymme 2 -Ns) 2 ] (2)mentioning

confidence: 99%

Ruthenium(II)/4,6-dimethyl-2-mercaptopyrimidine complexes: Synthesis, characterization, X-ray structures and in vitro cytotoxicity activities on cancer cell lines

et al. 2014

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“…文献报道木豆素 A、木豆素 C 具有抗脑缺血缺氧损伤 [1] 、治疗痢疾 [2] 、降低血糖和甘油三酯 [3] , 以及抗肿瘤 [4] 、保护神经 [5] 等作用. Cajanotone(具有较强的肿瘤细胞抑制活性 [6] .…”

unclassified

“…因此, 本文对木豆素 A、木豆素 C 及 Cajanotone 的合成方法进行了研究, 希望找到相对简单的合成方法, 为后续衍生物的合成提供参考. [8] , 之后用二氯亚砜氯代得到 3,5-二甲氧基苄氯(3), 再通过霍钠尔-沃兹沃思(HWE)反应以 93%收率得到(E)-3,5-二甲氧基二苯乙烯 (4) [8～11] , 化合物 4 经三溴化硼脱甲基得到(E)-3-羟基-5-甲氧基二苯乙烯(5) [12] , 化合物 5 与异戊烯基溴成醚得到(E)-3-异戊烯氧基-5-甲氧基二苯乙烯(6), 最后在弗罗里硅土(Florisil)催化下经 1,3-sigma 重排得到木豆素 A 和木豆素 C [13] . 合成路线如 Scheme 1 所示.…”

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Total Synthesis of Longistylin A, Longistylin C and Cajanotone

陈文章¹,

王聪²,

樊玲玲³

et al. 2015

Chin. J. Org. Chem.

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Natural products longistylin A, longistylin C and cajanotone belong to stilbenes family and exhibit varieties of bioactivities. Using Horner-Wadsworth-Emmons (HWE) and 1,3-sigma rearrangement reactions as key steps, longistylin A and longistylin C have been successfully synthesized in six steps from 3,5-dimethoxy benzoic acid. Besides, using Barbier and 1,3-sigma rearrangement reactions as key steps, cajanotone has been first prepared in eight steps from 3,5-dihydroxy benzoic acid.

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Ethnobotanical survey and cytotoxicity testing of plants of South-western Nigeria used to treat cancer, with isolation of cytotoxic constituents from Cajanus cajan Millsp. leaves

Cited by 155 publications

References 31 publications

Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Ruthenium(II)/4,6-dimethyl-2-mercaptopyrimidine complexes: Synthesis, characterization, X-ray structures and in vitro cytotoxicity activities on cancer cell lines

Total Synthesis of Longistylin A, Longistylin C and Cajanotone

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