Understanding the concept of chemistry can not only be done directly by studying chemistry, but even chemistry will also be more easily understood if contextualized with culture, because the concept of chemistry is very analogous to culture (Ethnochemistry). This paper will discuss Ethnochemistry in the local wisdom of the Sasak tribe, West Nusa Tenggara, Indonesia contained in the Merarik (wedding) tradition. In this tradition, there are social, moral and spiritual values such as the concept of giving and receiving, cooperation, mutual respect, and the concept of a mutual need to achieve stability. These concepts have very strong relevance to the theory of chemical bonds which includes the concept of electron stability, electron configuration, positive and negative ions, and the theory of chemical bond formation so that it can be concluded the theory of chemical bonds has interconnection with local wisdom of Sasak tribe (Ethnochemistry). The concept of material and its changes integrated into local Sasak wisdom are reflected in the use of chemical elements from various types of metals such as gold, silver, bronze, copper, brass, and various other metals for the manufacture of traditional ceremonial tools and traditional Sasak arts. Likewise, the concept of material change is found in food processing, traditional art tools and cultural products of the Sasak tribe. Thus the application of ethnhochemistry in chemistry learning can act as a natural laboratory & learning media so as to make chemistry learning more enjoyable and relevant to students' daily lives (contextual-based learning).