Ethnomedicinal and pharmacological properties of Caralluma tuberculata N. E. Brown – A review

doi:10.19045/bspab.2015.44008

Cited by 9 publications

(5 citation statements)

References 2 publications

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“…The high antibacterial activity of the Caralluma plant depicts that some natural compounds present in plants may lead to isolating the antibiotics. In the present study, the methanolic extract obtained from Caralluma tuberculate extract exhibited strong antimicrobial activities against (E. coli and Bacillus) while ethyl acetate extract showed strong antimicrobial activity against (Pseudomonas, Staphylococcus, B. subtilis, and P. aeruginous) (Al-Snafi, 2017;Bibi et al, 2015).…”

Section: Antibacterial Analysismentioning

confidence: 52%

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Screening of Phytochemical Compounds and Antimicrobial Activity of Caralluma tuberculate by In-Silico Study

Jamil,

Khan,

Jan

et al. 2023

SJA

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Medicinal plants have played a vital role in drug production. Herbal medicines have proved to be safe to use. Crude extract of Caralluma tuberculata stem was used to examine its antibacterial activity and phytochemical screening. Antibacterial assay was carried out by well diffusion method. A maximum number of compounds were eluted by methanolic extract by thin-layer chromatography and a total of 70 compounds were identified by GC-MS analysis. The phytochemical screening showed that the methanolic extract of the whole plant was rich in alkaloids and tannins. Zones of inhibition around the bacterial colonies show the antibacterial activity of the plant. Extract of the targeted plant was effective against all test organisms Escherichia coli, Bacillus, Staphylococcus, and Pseudomonas that revealed methanolic extract of medicinal plant Caralluma possesses high antimicrobial activity against E. coli. and Bacillus causing 16mm±0.53 and 12.6±0.43 while ethyl acetate solvent of plant extract against E. coli. and Bacillus inhibited 08±0.0.03 and 9.6±0.32mm respectively. Ethyl acetate extract showed the best inhibition against Pseudomonas and Staphylococcus 15.6±0.54 and 9.8±0.41mm respectively and the same extract exhibited the zone inhibition 0.68±0.14 and 0.53±0.51mm against B. subtilis and P. aeruginous. The inhibitory effect was compared to standard gentamycin. Four bioactive compounds were subjected to molecular docking from which all targeted compounds received scores ranging from (−3.5 to −5.9) kcal/mol with targeted protein. Hence the study revealed that bioactive compounds derived from the Caralluma tuberculata plant pose highly antibacterial activity and might be used to synthesize the antibacterial drug.

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Section: Antibacterial Analysismentioning

confidence: 52%

“…Plant extract contains many phytochemical compounds that possess highly medicinal properties. (Al-Snafi, 2017;Bibi et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

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Screening of Phytochemical Compounds and Antimicrobial Activity of Caralluma tuberculate by In-Silico Study

Jamil,

Khan,

Jan

et al. 2023

SJA

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“…Correspondingly, C. tuberculata, a family member of Asclepiadaceae (milkweed family), is an edible, juicy, leafless stiff plant that commonly grows in dry, undomesticated regions of Pakistan and other countries such as Saudi Arabia, Nigeria, and Iran (Mudrikah et al, 2015). C. tuberculata is extensively found in the mountainous areas of Khyber Pakhtunkhwa province of Pakistan, where it is called Pamankay in the local Pashto language.…”

Section: Introductionmentioning

confidence: 99%

“…The plant has commonly known for its ethnomedicinal applications including the treatment of dysentery, jaundice, constipation, stomach pain, blood purification, liver ailments and hypertension (Baig et al, 2021;Delaviz et al, 2017;Adnan et al, 2014). The disease prevention and health-promoting effects of the plant are primarily attributed to its antioxidant, antibacterial (Mudrikah et al, 2015), hypolipidemic, anti-hyperglycemic (Abdel-Sattar et al, 2011Essam et al, 2011), and in vitro anticancer potentials (Waheed et al, 2011). The plant has been shown to contain many bioactive secondary metabolites including steroids, reducing sugars, terpenoids, beta cyanin, tannins and amino acids.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effects of walnut oil and Caralluma tuberculata against paracetamol in experimentally induced liver toxicity in mice

Sana¹,

Rahman²,

Zahid³

et al. 2022

Acta Biochim Pol

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Walnut Oil and Caralluma are edible and form part of the traditional medicine system in many countries. These are frequently used in traditional medicine as remedies to relieve a wide range of illnesses and health problems. Walnut Oil and Caralluma species have demonstrated anti-inflammatory, anti-nociceptive, antidiabetics, hepatoprotective, gastric mucosa protecting, antimalarial, antioxidant, anti-trypanosomal, appetite suppressant and cytotoxic activities. The current study was planned to study the impacts of 21 days’ oral administration of walnut oil and methanolic extract of Caralluma tuberculata on the levels of some liver-associated parameters and hematological parameters in paracetamol intoxicated mice. It was observed that paracetamol intoxication resulted in a considerable rise in serum ALT, cholesterol, triglycerides, Creatinine, and urea levels while a decrease in HDL level in comparison to mice normal control group (P<0.05). Serum ALT, cholesterol, triglycerides, creatinine, and urea levels of mice that were administered with walnut oil and methanolic extract ofC. tuberculata at the doses of (1 ml/kg, 2 ml/kg and 3 ml/kg body weight) were significantly lower when compared to toxic control mice group (P<0.05), While HDL level was significantly increased. The significant reduction had also been observed in the levels of serum parameters of mice group, which received standard hepato-protective drug i.e., vitamin C, at the dose of 8 mg/kg body weight (P<0.05). Based on these results, it was evident that liver toxicity caused by the paracetamol administration has recovered toward the normal range by the walnut oil and C. tuberculata extract. Therefore, the present study revealed that (walnut oil andC. tuberculata) exhibit hepatoprotective activities in paracetamol intoxicated mice.

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Exploration of microbiome of medicinally important plants as biocontrol agents against Phytophthora parasitica

2021

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Ethnomedicinal and pharmacological properties of Caralluma tuberculata N. E. Brown – A review

Cited by 9 publications

References 2 publications

Screening of Phytochemical Compounds and Antimicrobial Activity of Caralluma tuberculate by In-Silico Study

Screening of Phytochemical Compounds and Antimicrobial Activity of Caralluma tuberculate by In-Silico Study

Hepatoprotective effects of walnut oil and Caralluma tuberculata against paracetamol in experimentally induced liver toxicity in mice

Exploration of microbiome of medicinally important plants as biocontrol agents against Phytophthora parasitica

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