Ethosomes: An Exciting and Promising Alcoholic Carrier System for Treating Androgenic Alopecia

Sankar, Veintramuthu; Ramesh, Santhanam; Karthik, S.

doi:10.5772/intechopen.79807

Cited by 6 publications

(6 citation statements)

References 10 publications

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“…This method is mainly utilised for developing multilamellar vesicles. 17 They used a rabbit model for the investigation. They concluded that 5-fluorouracil containing ethosomes showed better results than 5-fluorouracil only.…”

Section: ) Rotary Film Evaporation Methodsmentioning

confidence: 99%

Dermal and Transdermal Drug Delivery through Vesicles and Particles: Preparation and Applications

Garg¹,

Jain²

2021

Adv Pharm Bull

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Transdermal delivery over the past decade has become the field of interest for drug delivery due to its various advantages such as no first-pass metabolism, increased drug bioavailability, and easy administration. Different vesicle systems like ethosomes, liposomes, niosomes, and transferosomes along with particle systems like lipid nanoparticles, polymeric nanoparticles, carbon nanotubes, and fullerenes have been developed. These vesicles and particle systems have been developed using various easy and effective methods like cold injection method, rotary film evaporation, thin film hydration, high shear homogenization, solvent extraction method, and many more. These drug delivery systems are a very effective and feasible option for transdermal drug delivery and further developments can be made to increase their use. This article explains in detail the preparation methods and applications for these drug delivery systems.

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Section: ) Rotary Film Evaporation Methodsmentioning

confidence: 99%

Dermal and Transdermal Drug Delivery through Vesicles and Particles: Preparation and Applications

Garg¹,

Jain²

2021

Adv Pharm Bull

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“…Phosphatides (2-5%) [23] L-α-Lecithin, Phospholipon, and Phospholipon 90NG [24] Vesicle formation Edge stimulator [25] Oleic acid, cholalic acid sodium salt, Tween 80, Tween 20, desoxycholic acid sodium salt, and Span 80 [12] It gives the vesicle flexibility and improves penetration.…”

Section: Architecture Excipients Functionmentioning

confidence: 99%

Untitled

2023

AJP

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Since a few years ago, the delivery of drugs through the skin has gained popularity. By doing so, it gets around problems with the oral route. Despite the fact that only a few pathways are as appealing as the transdermal route, it is difficult to deliver drugs through the skin. Researchers have developed a technique that allows the medicine to be encapsulated into vesicles, which may then go deep into the layer of skin to reach the target spot. Consequently, bioactive agents can penetrate the skin more effectively. Liposomes, niosomes, transethosomes, and transferosomes are vesicular systems that frequently remain collected in the skin layers. Transethosomes can pass through multiple layers of skin because they have tiny particle sizes and can change the form of vesicles more easily than another vesicular system. Transethosomes allow the medicine to be conveniently delivered to the target place. Ethanol, phospholipids, and an edge stimulator make up transethosomes. Transethosomes' ability to penetrate the skin is improved by ethanol and edge stimulators. It increases patient cooperation because it is a non-intrusive procedure. It also improves the effectiveness of drug entrapment. These vesicles can hold a wide range of medications, including pain relievers, antitumor medicines, steroids, proteins, and peptides.

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“…Phospholipids (2 %-5%) 24 Soya phosphatidyl choline (S-75), Lipoid S100,Phospholipon 90G. 25 Component which forms vesicles.…”

Section: Gras Listed Rolementioning

confidence: 99%

“…Ethanol, Isopropyl Alcohol, Propylene glycol, transcutol. 25 It provides softness to the vesicle membrane Water ( qs 100) Water Used as a vesicle forming agent Epidermis: It is the outer layer of skin and is made up of keratinocytes. 33 It contains two types of epidermal layers i.e.…”

Section: Alcohol (30% -40%) 13mentioning

confidence: 99%

Nano-transethosomes: A Novel Tool for Drug Delivery through Skin

Bajaj¹,

Parab²,

Shidhaye³

2021

IJPER

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Transdermal drug delivery has become a popular tool from last few years. It overcomes drawbacks which are encountered with the oral route. Though very few routes are as attractive as transdermal route, transport of drug through the skin is challenging. In order to overcome the challenges, researchers have found a system in which the drug is encapsulated into the vesicle and these vesicles can penetrate deeper into the skin to hit the target site. Hence, better skin penetration of bioactive agents can be achieved. Vesicular systems like liposomes, niosomes, ethosomes and Transferosomes tend to remain accumulated in the skin layers. Since Transethosomes have small particle size and can easily alter the shape of vesicle as compared with other vesicular systems; it can penetrate through the layers of skin. Hence, the drug encapsulated into Transethosomes can easily reach the target site. Transethosomes consist of ethanol, phospholipids along with an edge activator. Ethanol and edge activator help to enhance skin permeation of Transethosomes. Since it is a non-invasive technique, it improves patient compliance. It also increases drug entrapment efficiency. These vesicles can accommodate different variety of drugs such as anticancer, corticosteroids, proteins and peptides, analgesics.

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Ethosomes: An Exciting and Promising Alcoholic Carrier System for Treating Androgenic Alopecia

Cited by 6 publications

References 10 publications

Dermal and Transdermal Drug Delivery through Vesicles and Particles: Preparation and Applications

Dermal and Transdermal Drug Delivery through Vesicles and Particles: Preparation and Applications

Untitled

Nano-transethosomes: A Novel Tool for Drug Delivery through Skin

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