Ethyl acetate fraction of Eclipta alba: a potential phytopharmaceutical targeting adipocyte differentiation

Gupta, Abhishek; Kumar, Ashok; Kumar, Durgesh; Nandan, Shiv; Shankar, Kripa; Varshney, Salil; Rajan, Sujith; Srivastava, Ankita; Gupta, Sanchita; Kanojiya, Sanjeev; Narender, T.; Gaikwad, Anil Nilkanth

doi:10.1016/j.biopha.2017.10.002

Cited by 16 publications

(4 citation statements)

References 29 publications

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“…As described earlier (59), serum triglycerides were estimated using a triglyceride estimation kit (TR210) from Randox laboratories as per the manufacturer's protocol. Briefly, 5µl of serum sample or standard was taken in a 96 well plate.…”

Section: Assessment Of Serum Triglyceridesmentioning

confidence: 99%

Human CIDEC transgene improves lipid metabolism and protects against high-fat diet–induced glucose intolerance in mice

Gupta¹,

Balakrishnan²,

Karki³

et al. 2022

Journal of Biological Chemistry

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Section: Assessment Of Serum Triglyceridesmentioning

confidence: 99%

Human CIDEC transgene improves lipid metabolism and protects against high-fat diet–induced glucose intolerance in mice

Gupta¹,

Balakrishnan²,

Karki³

et al. 2022

Journal of Biological Chemistry

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“…Among the anti-obesity effects of Juniperus communis [ 104 ], Ramulus mori [ 111 ], Vibrunum opulus [ 106 ], Paullinia cupana [ 96 ], Peucedanum japonicum [ 23 ], Aster yomena [ 97 ], Prunus salicina [ 98 ], Eclipta alba [ 99 ], and Polygonum cuspidatum [ 92 ] evaluated on 3T3-L1 cells, Eclipta alba showed the highest activity as it decreased the expression of PPARα (1.9 fold), C/EBPα (1.8 fold), FAS (1.4 fold) and FABP4 (1.8 fold) and also decreased the concentration of lipids in terms of cholesterol and triglycerides in these adipocytes. The above-described plants regulated the transcription factors and lipid accumulation in 3T3-L1 adipocytes.…”

Section: Anti-obesity Effects Of Different Plant Resourcesmentioning

confidence: 99%

A Review on Obesity Management through Natural Compounds and a Green Nanomedicine-Based Approach

et al. 2021

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Obesity is a serious health complication in almost every corner of the world. Excessive weight gain results in the onset of several other health issues such as type II diabetes, cancer, respiratory diseases, musculoskeletal disorders (especially osteoarthritis), and cardiovascular diseases. As allopathic medications and derived pharmaceuticals are partially successful in overcoming this health complication, there is an incessant need to develop new alternative anti-obesity strategies with long term efficacy and less side effects. Plants harbor secondary metabolites such as phenolics, flavonoids, terpenoids and other specific compounds that have been shown to have effective anti-obesity properties. Nanoencapsulation of these secondary metabolites enhances the anti-obesity efficacy of these natural compounds due to their speculated property of target specificity and enhanced efficiency. These nanoencapsulated and naive secondary metabolites show anti-obesity properties mainly by inhibiting the lipid and carbohydrate metabolizing enzymes, suppression of adipogenesis and appetite, and enhancing energy metabolism. This review focuses on the plants and their secondary metabolites, along with their nanoencapsulation, that have anti-obesity effects, with their possible acting mechanisms, for better human health.

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“…E. prostrata is a medium-sized, branched, annual herb-bearing white flower natively found in the tropical and subtropical regions of the world [ 9 , 10 ]. It grows mostly in moist sites such as swamp edges, river or lake banks and edge of rice-fields and easily propagated and spread throughout China, India, Nepal, Brazil and other parts of the world [ 8 , 11 , 12 , 13 ]. It is widely distributed in tropical and sub-tropical regions of Asia, Africa, and South America ( Figure 2 ) [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Eclipta prostrata (L.) L. (Asteraceae): Ethnomedicinal Uses, Chemical Constituents, and Biological Activities

Timalsina

Devkota

2021

Biomolecules

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Eclipta prostrata (L.) L. (Syn.: Eclipta alba (L.) Hassak, Family: Asteraceae) is an important medicinal plant in the tropical and subtropical regions. It is widely used in treating various diseases of skin, liver and stomach in India, Nepal, Bangladesh, and other countries. The main aim of this review was to collect and analyze the available information on traditional uses, phytoconstituents, and biological activities of E. prostrata. The scientific information was collected from the online bibliographic databases such as Scopus, MEDLINE/PubMed, Google Scholar, SciFinder, etc. and books and proceedings. The active phytochemicals were coumestan derivatives, phenolic acid derivatives, flavonoids, triterpenoid and steroid saponins, substituted thiophenes, etc. Various extracts and isolated compounds of E. prostrata showed a wide range of biological activities such as antimicrobial, anticancer, hepatoprotective, neuroprotective and hair growth promoting activities. Relatively a few studies have been performed to reveal the exact phytoconstituents responsible for their corresponding pharmacological activities. Future studies should focus on detailed mechanism based studies using animal models and clinical studies.

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Ethyl acetate fraction of Eclipta alba: a potential phytopharmaceutical targeting adipocyte differentiation

Cited by 16 publications

References 29 publications

Human CIDEC transgene improves lipid metabolism and protects against high-fat diet–induced glucose intolerance in mice

Human CIDEC transgene improves lipid metabolism and protects against high-fat diet–induced glucose intolerance in mice

A Review on Obesity Management through Natural Compounds and a Green Nanomedicine-Based Approach

Eclipta prostrata (L.) L. (Asteraceae): Ethnomedicinal Uses, Chemical Constituents, and Biological Activities

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