EtOH self-administration in anticipation of noise stress in C57BL/6J mice

Mollenauer, Sandra; Bryson, Rebecca; Robison, Molly; Sardo, James; Coleman, Christopher D.

doi:10.1016/0091-3057(93)90313-i

Cited by 22 publications

(10 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The direct relationship between ethanol PC and novelty-induced motor activity after the initial saline injection noted for female mice in our study supports this hypothesis. This finding is consistent with reports of enhanced ethanol PC and ethanol SA by stress and corticosterone treatment (Bienkowski et al, 1996;Mollenauer et al, 1993;Le et al, 1997;Pohorecky, 1990;Fahlke et al, 1995), as well as with evidence of increased anxiety and noveltyinduced locomotion by ethanol-preferring P rats, compared with NP rats . It is interesting that the relationship between novelty locomotion and ethanol PC in our study was gender-specific, because novelty produces greater corticosterone response for female than male C57 mice (Hennessy et al, 1977).…”

Section: Relationship Between Ethanol Pc and Ethanol Consumptionsupporting

confidence: 93%

Ethanol Consumption and Place‐Preference Conditioning in the Alcohol‐Preferring C57BL/6 Mouse: Relationship with Motor Activity Patterns

Nocjar

Middaugh

Tavernetti

1999

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

Ethanol place-preference conditioning (PC) was conducted in drug-naive and ethanol pre-exposed female and male C57BL/6J (C57) mice to assess whether environmental cues can develop positive incentive value for ethanol-preferring animals when associated with administration of ethanol. After 12 days episodic access to free-choice ethanol and/or water self-administration, mice received eight ethanol injections (1.75 g/kg/i.p.) 5 min before placement in their nonpreferred PC chamber and eight saline injections paired with their preferred chamber. Control mice received eight saline injections (20 ml/kg) in both their preferred and nonpreferred chambers. Mice of both sexes developed strong ethanol PC. Correlational analysis indicated that the strength of ethanol PC for mice with a prior ethanol drinking experience was inversely related to the amount of ethanol consumed regardless of gender. Furthermore, depending on gender and previous ethanol drinking experience, ethanol PC was differentially related to initial baseline motor activity, the initial motor response to ethanol, or rapid change in the motor response to ethanol. Thus, a complicated relationship between neural systems that mediate ethanol reward and motor activity may exist as suggested by current addiction theory.

show abstract

Section: Relationship Between Ethanol Pc and Ethanol Consumptionsupporting

confidence: 93%

Ethanol Consumption and Place‐Preference Conditioning in the Alcohol‐Preferring C57BL/6 Mouse: Relationship with Motor Activity Patterns

Nocjar

Middaugh

Tavernetti

1999

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

show abstract

“…The significance of stress in drug‐seeking behavior has also been amply documented in the animal literature. Physical, social, and emotional stress can facilitate acquisition or increase self‐administration of cocaine,47–49 heroin,50 and ethanol51–53 in rodents and nonhuman primates. Stressful stimuli have also been shown to elicit reinstatement of cocaine, heroin, and ethanol‐seeking behavior in drug‐free animals after extinction,54–56 and these findings provide experimental support for the role of stress in relapse.…”

Section: Dysregulation Of Brain Stress Systemsmentioning

confidence: 99%

Compulsive Drug‐Seeking Behavior and Relapse

Weiss

Ciccocioppo

Parsons

et al. 2001

Annals of the New York Academy of Sciences

353

View full text Add to dashboard Cite

The development of addiction and vulnerability to relapse following withdrawal is proposed to be the result of neuroadaptive processes within the central nervous system that oppose the acute reinforcing actions of drugs of abuse. These changes lead to impairment in the mechanisms that mediate positive reinforcement and the emergence of affective changes such as anxiety, dysphoria, and depression during withdrawal. Considerable evidence exists implicating perturbations in DA and 5‐HT transmission in the nucleus accumbens—neurochemical systems that are activated by cocaine and ethanol self‐administration and deficient during withdrawal—as potential substrates for these affective changes. In addition, growing evidence suggests that enhanced CRF release in the central nucleus of the amygdala represents a mechanism underlying the anxiogenic and stress‐like consequences of withdrawal that are common to all drugs of abuse. A growing body of evidence also implicates dysregulation of the non‐neuroendocrine CRF stress system within the central nucleus of the amygdala as a common factor in the anxiogenic and aversive consequences of withdrawal from drugs of abuse. Moreover, a possible link may exist between long‐lasting abnormalities in CRF function in the CeA and vulnerability to relapse during protracted abstinence. Another presumably critical element contributing to the chronic relapsing nature of drug addiction is the learned responses to drug‐related stimuli. The long‐lasting efficacy of drug‐ and alcohol‐associated contextual stimuli in eliciting drug‐seeking behavior in animal models of relapse resembles the endurance of conditioned cue reactivity and cue‐induced cocaine craving in humans and confirms a significant role of learning factors in the long‐lasting addictive potential of cocaine. With cocaine, D1‐dependent neural mechanisms within the medial prefrontal cortex and basolateral amygdala may be important substrates for the motivating effects of drug‐related environmental stimuli. With ethanol, available data suggest a role for opioid receptors in the mediation of conditioned drug‐seeking behavior. Finally, conditioning factors (i.e., exposure to drug‐associated stimuli) and stress can interact to augment vulnerability to relapse. This finding emphasizes that it will be important to consider the simultaneous effects of multiple environmental triggers for relapse in the development of treatment and medication strategies.

show abstract

“…Furthermore, some stressors have been shown to increase self-administration of EtOH (e.g. Eckardt et al 1998; Mollenauer et al 1993; Wolffgramm 1990) and inhibiting the stress axis via CRH antagonism reduces EtOH consumption (Funk et al 2006). In the clinic, alcoholism and anxiety disorders are frequently co-morbid (Kushner et al 1990; Bradizza et al 2006; Conway et al 2006; Fein et al 2006; Vendruscolo et al 2006) and a significant proportion of alcohol-dependent individuals report that alcohol is reinforcing because it reduces anxiety (Barrenha and Chester 2007; Hill and Angel 2005; Koven et al 2005; Lawyer et al 2002).…”

mentioning

confidence: 99%

Influence of β-Endorphin on anxious behavior in mice: interaction with EtOH

et al. 2008

View full text Add to dashboard Cite

Rationale-The opioid peptide β-endorphin (β-E) is synthesized by the pro-opiomelanocortin gene in response to environmental stressors and alcohol administration and is implicated in the behavioral sequelae associated with these stimuli.Objectives-We sought to determine the influence of β-E on the stress response by evaluating basal measures of anxiety as well as on EtOH-induced anxiolytic behavior using transgenic mice that differ with respect to β-E.Methods-Anxious behavior was evaluated for male and female heterozygous, wild type, and β-E knockout mice using the Light-Dark Box and Plus Maze assays. Subsequent tests evaluated behavior 20 min after administration of intraperitoneal saline or EtOH (0.5, 1.0 and 1.5 g/kg).Results-We observed an inverse relationship between β-E levels and the percentage of entries into open arms of the Plus Maze as well as the time spent in either the open arms or the light compartment of the Light-Dark box during basal conditions, suggesting that this peptide normally inhibits anxious behavior. However, mice lacking β-E demonstrated an exaggerated anxiolytic response to EtOH in these assays.Conclusions-These data suggest that β-E moderates the response to stressful stimuli and supports the hypothesis that this peptide influences the behavioral effects of EtOH. KeywordsAddiction; Ethanol; Anxiety; Opioids; Mice; Transgenic; Self-Medication β-endorphin (β-E) is a 31 amino-acid peptide that is cleaved from the carboxyl terminus of the Proopiomelanocortin (POMC) gene. As a member of the large family of opioid peptides that are widely and differentially distributed throughout the nervous system, it has been implicated in a variety of behaviors including the regulation of pain and reward, as well as in modulating neurocircuitry involved in learning and memory, motivation and processes associated with stress, fear or anxiety (e.g. Bloom 1980). The response to stressors involves a complex cascade of endocrine, autonomic and behavioral changes that seem to be generally aimed at maintaining or restoring homeostasis. At least in part because of its complexity, neither a precise definition nor thorough knowledge of the neurobiological underpinnings of the stress response has been elucidated (Pacak and Palkovitis 2001). Nonetheless, nearly any operational understanding includes activation of the hypothalamic-pituitary-adrenal (HPA) axis. This reaction involves Correspondence to: Judith E. Grisel, judy.grisel@furman.edu. NIH Public AccessAuthor Manuscript Psychopharmacology (Berl). Author manuscript; available in PMC 2010 February 9. The most well-studied effect of β-E is its ability to modulate pain, but an early report by Fratta et al. (1981) suggested that central administration of β-E produced opposite effects to that of ACTH administration ("reciprocal antagonism") on several behaviors in rats including cataplexy, rigidity and analgesia, and supported the notion that β-E is directly implicated in the homeostatic regulation of ACTH response. Indeed, β-E synthesis and release is prec...

show abstract

EtOH self-administration in anticipation of noise stress in C57BL/6J mice

Cited by 22 publications

References 14 publications

Ethanol Consumption and Place‐Preference Conditioning in the Alcohol‐Preferring C57BL/6 Mouse: Relationship with Motor Activity Patterns

Ethanol Consumption and Place‐Preference Conditioning in the Alcohol‐Preferring C57BL/6 Mouse: Relationship with Motor Activity Patterns

Compulsive Drug‐Seeking Behavior and Relapse

Influence of β-Endorphin on anxious behavior in mice: interaction with EtOH

Contact Info

Product

Resources

About