Etude des anticorps anti-Rh dans le liquide amniotique

Biermé, S; Marty, Y; Boissezon, J.F. de; Ducos, J

doi:10.1016/s0035-2977(68)80018-5

Cited by 3 publications

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“…By means of the albumin-papain technique, Bierme et al (2) demonstrated the presence of anti-D in the amniotic fluid of 57 % of 102 anti-D immunized pregnant women. They found that the presence of anti-D in amniotic fluid implied an unfavourable prognosis.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Quantitative Determination of Rhesus Antibody (Anti‐D) In Maternal Serum and Amniotic Fluid

Jørgensen

Rebbe

1971

Acta Obstet Gynecol Scand

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Quantitative determinations of anti‐D in sera and amniotic fluids were performed simultaneously in 63 pregnant Rh‐immunized women with Rh‐positive foetuses. It was demonstrated that the ratio of serum antibody to amniotic fluid antibody as a rule is the same. A quantitative analysis of the serum antibody enabled us to identify the foetuses with good prognoses. For ths remaining cases, it was possible to distinguish between moderate to severe cases and very severe cases of erythroblastosis by determining also the concentration or titre of amniotic fluid antibody. Where specimens were taken less than a fortnight before birth, the titre values alone made it possible to prognosticate correctly in 80% cases. Correlation of amniotic fluid antibody and bilirubin levels led to correct prognoses in 92% of the cases. With this background a plan for the control of pregnant Rh‐immunized women is suggested.

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Section: Discussionmentioning

confidence: 99%

Prognostic Value of Quantitative Determination of Rhesus Antibody (Anti‐D) In Maternal Serum and Amniotic Fluid

Jørgensen

Rebbe

1971

Acta Obstet Gynecol Scand

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Observations on Rh Iso-Immunisation: Past, Present and Future

Fraser¹,

Tovey²

1976

Clinics in Haematology

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Estimation of Antibody Protein in Amniotic Fluid to Predict Severity in Rhesus Haemolytic Disease

Fraser

Tovey

1972

BJOG

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Using rhesus antibody quantitation in amniotic fluid samples as a supplement to Liley's spectrophotometric method, the accuracy of prediction of severity of rhesus haemolytic disease has been improved from 77 to 90 per cent. When the antibody protein level was less than 0 -2 pg. per ml. the cord blood haemoglobin value was more than 11 -0 g. per 100 ml. However, when the antibody protein value was greater than0.6 pg. per ml. thecord blood haemoglobin level was less than 8.0 g. per 100 ml. In 32 of 34 rhesus (D) negative babies the amniotic fluid contained neglible amounts of anti-D.

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Etude des anticorps anti-Rh dans le liquide amniotique

Cited by 3 publications

References 0 publications

Prognostic Value of Quantitative Determination of Rhesus Antibody (Anti‐D) In Maternal Serum and Amniotic Fluid

Prognostic Value of Quantitative Determination of Rhesus Antibody (Anti‐D) In Maternal Serum and Amniotic Fluid

Observations on Rh Iso-Immunisation: Past, Present and Future

Estimation of Antibody Protein in Amniotic Fluid to Predict Severity in Rhesus Haemolytic Disease

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