Étude phytochimique et pharmacologique d’&lt;i&gt;Alchornea cordifolia&lt;/i&gt; (Schum. &amp; Thonn.) Mull. Arg. et de &lt;i&gt;Mangifera indica&lt;/i&gt; dans le traitement traditionnel de la maladie hémorroïdaire

Nga, Emmanuel Nnanga; Yinyang, Jacques; Bidias, Elisabeth Baran à; Etame-Loe, Gisèle; Dibong, Siegfried Didier

doi:10.4314/jab.v109i1.9

Cited by 13 publications

(9 citation statements)

References 19 publications

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“…According to the OECD Globally Harmonized Classification System (GHS), ETAAC is classified as non-toxic orally [14] . This same method was used by [17] who showed that the LD50 of ETAAC is greater than 5000 mg/kg of bw. Evaluating the signs of clinical and / or biological intoxication linked to repeated use of medicinal plants is judicious, especially since the acute use of medicinal plants is rather rare in traditional medicine [18] .…”

Section: Discussionmentioning

confidence: 99%

Assessment of the acute, subacute and Subchronic toxicity of a total aqueous extract of leaves of Alchornea cordifolia (Schumach and Thonn) Müll Arg (Euphorbiaceae) on rats Wistar

Goueh¹,

Allassane²,

John³

et al. 2021

J Pharmacogn Phytochem

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The leaves of Alchornea cordifolia are traditionally used by African populations for the treatment of several diseases. The acute toxicity study concluded that the total aqueous extract of Alchornea cordifolia (ETAAC) is not toxic by single administration and that its LD50 is greater than 5000 mg/kg of body weight (bw). Tests carried out by daily administration of ETAAC did not result in any significant change in the body weight of the animals and the weight of vital organs. After 28 days of treatment, no significant difference was observed in the figurative elements of the blood and in the biochemical parameters. Significant decreases were observed in urea and alanine-amino transferase after 60 days of treatment. Alchornea cordifolia does not affect the functioning of the kidneys, liver and heart. It is therefore not toxic at doses of 100 mg/kg of bw, 200 mg/kg of bw and 400 mg/kg of bw in rats.

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Section: Discussionmentioning

confidence: 99%

Assessment of the acute, subacute and Subchronic toxicity of a total aqueous extract of leaves of Alchornea cordifolia (Schumach and Thonn) Müll Arg (Euphorbiaceae) on rats Wistar

Goueh¹,

Allassane²,

John³

et al. 2021

J Pharmacogn Phytochem

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“…Les plantes les plus incriminées étaient Citrus limon (17.14%), Carica papaya (11.43%), Manguifera indica (8.57%) et Garcinia kola (8.57%). Ainsi selon des études faites sur certaines de ces plantes, elles ont des propriétés anti-inflammatoires, anxiolytiques, antalgiques et antidépresseurs (Mpondo et al, 2012;Nga et al, 2017;Idris et al, 2020). Nous avons enregistré 0.15% des sportifs qui avait affirmé déjà utilisé l'amphétamine qui est un produit interdit.…”

Section: Discussionunclassified

Perceptions sur les Conduites Dopantes dans le Sport dans la Ville de Bobo-Dioulasso (Burkina Faso)

Ouedraogo

Guenné²,

Somda

et al. 2022

ESJ

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L’objectif de cette étude était d’évaluer les Connaissances, Attitudes et Pratiques (CAP) chez les sportifs face aux conduites dopantes dans la ville de Bobo-Dioulasso au Burkina Faso. Il s’est agi d’une étude transversale, de novembre 2020 à janvier 2021, portant sur 390 sportifs de trois disciplines sportives: football, basketball, et handball. Les données ont été collectées à partir de questionnaires anonymes administrés ou auto-administrés. Au total, 73.1% (285) des sportifs ont participé à l’étude. Le sexe masculin était majoritaire, soit un sex-ratio de 2.47 et l’âge moyen des sportifs était de 21.4±3.68 ans. De plus, 69.12% (197) des sportifs ont déclaré avoir des connaissances sur le dopage ou sur les conduites dopantes et que les canaux privilégiés étaient les mass médias (55.79%) et les amis (10.18%). A l’issue de l’enquête CAP, 76.84% (219) ont déclaré pratiqué les conduites dopantes (p<0.001) et le football était de loin le sport qui favorisait ces conduites (p<0.001). Les conduites dopantes étaient corrélées positivement avec le sexe masculin (p<0.001), l’âge élevé du sportif (p=0.009) et son faible niveau d’instruction (p=0.006). Par ailleurs, les substances utilisées citées pour ces conduites étaient des produits pharmaceutiques, non pharmaceutiques et 9.82% (28) des sportifs utilisaient des plantes médicinales locales. L’amphétamine, une substance interdite, a été utilisée par 0.15% des sportifs. L’étude revèle que les participants ont une conduite dopante élevée et un manque d’information sur ces conduites. Des recommandations ont été formulées à leur regard afin de leur éviter les dangers liés au dopage. This study focuses on evaluating the Knowledge, Attitudes, and Practices (KAP) of sportsmen and women on doping behaviour in the city of Bobo-Dioulasso in Burkina Faso. It was a cross-sectional study, from November 2020 to January 2021, consisting of 390 athletes in three sports: football, basketball, and handball. The data were collected by using anonymous administered questionnaires or self-administered questionnaires. A total of 73.1% (285) of the athletes agreed to participate in the study. The majority were male, with a sex ratio of 2.47, and the mean age of the athletes was 21.4±3.68 years. 69.12% (197) of the athletes also stated that they had knowledge about doping or doping behaviour, and the source of this information was from mass media (55.79%) and friends (10.18%). From the KAP survey, 76.84% (219) declared that they practised doping behaviour (p<0.001) and football was the sport that favoured this behaviour (p<0.001). Doping behaviours were positively correlated with male gender (p<0.001), older age (p=0.009), and lower education level (p=0.006). The substances used were pharmaceutical and non-pharmaceutical, while 9.82% (28) of the athletes used local medicinal plants. Amphetamine, an illegal substance, was used by 0.15% of the athletes. The study further reveals that participants have a high level of doping behaviour and a lack of information about these behaviours. Recommendations were formulated for them to avoid the dangers of doping.

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“…Oral acute toxicity study of JCLAE showed a lethal dose 50 (LD 50 ) greater than 5000 mg/kg body weight. Dabiré et al [9]; Nga et al [10] and Ping et al [11] Hematological analyses showed that total Jatropha curcas leaves aqueous extract did not cause significant changes in the number of erythrocytes and leucocytes. On the other hand, platelets number and mean platelet volume decreased significantly between batch I, batch III and IV respectively, and between batch I and batch IV.…”

Section: Discussionmentioning

confidence: 99%

In Vivo Evaluation of <i>Jatropha curcas</i> L (Euphorbiaceae) Leaves Acute and Subacute Toxicity in Mice

Sawadogo

Sanou²,

Dabiré³

et al. 2018

J. Sci. Res.

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Jatropha curcas is a medicinal plant whose dead leaves are particularly used in arterial hypertension and diabetes treatment. The purpose of this study is to conduct an acute and subacute toxicity study of Jatropha curcas leaves aqueous extract (JCLAE) using OECD method. For acute toxicity, dose limits of 2000 and 5000 mg/kg were used. In subacute toxicity study 4 batches were constituted including a control batch that received distilled water for 28 days and the other 3 batches, JCLAE doses of respectively 200, 400, 800 mg/kg for the same duration. The LD50 was determined and the hematological, biochemical and histological parameters were analyzed in mice. The LD50 is greater than 5000 mg/kg. HDL-C is the only biochemical parameter that has experienced significant rise variation. Hematological analysis showed a decrease in mean platelet volume and Platelets number. The histological study revealed cases of hepatic cellular apoptosis and kidneys tubular necrosis among animals treated with highest dose. JCLAE is less toxic than Jatropha curcas leaves aqueous extract and high-dose JCLAE also has a moderate toxic effect on thrombocyte line and a protective effect on cardiovascular system.

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Étude phytochimique et pharmacologique d’<i>Alchornea cordifolia</i> (Schum. & Thonn.) Mull. Arg. et de <i>Mangifera indica</i> dans le traitement traditionnel de la maladie hémorroïdaire

Cited by 13 publications

References 19 publications

Assessment of the acute, subacute and Subchronic toxicity of a total aqueous extract of leaves of Alchornea cordifolia (Schumach and Thonn) Müll Arg (Euphorbiaceae) on rats Wistar

Assessment of the acute, subacute and Subchronic toxicity of a total aqueous extract of leaves of Alchornea cordifolia (Schumach and Thonn) Müll Arg (Euphorbiaceae) on rats Wistar

Perceptions sur les Conduites Dopantes dans le Sport dans la Ville de Bobo-Dioulasso (Burkina Faso)

In Vivo Evaluation of <i>Jatropha curcas</i> L (Euphorbiaceae) Leaves Acute and Subacute Toxicity in Mice

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