Eugenol: Some Pharmacologic Observations

Sticht, Frank D.; Smith, Roy M.

doi:10.1177/00220345710500062801

Cited by 47 publications

(24 citation statements)

References 3 publications

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“…Although the action of eugenol is thought to be analgesic (Feng and Lipton, 1987;Thompson and Eling, 1989), authors reported that eugenol appears to have other actions (Sticht and Smith, 1971;Brodin and Roed, 1984). This compound reduces arterial blood pressure in dogs after intravenous injections, and increases blood flow after both intra-arterial and intravenous injections (Sticht and Smith, 1971), suggesting that the action of eugenol on the cardiovascular system might be on blood vessels.…”

Section: Introductionmentioning

confidence: 99%

“…This compound reduces arterial blood pressure in dogs after intravenous injections, and increases blood flow after both intra-arterial and intravenous injections (Sticht and Smith, 1971), suggesting that the action of eugenol on the cardiovascular system might be on blood vessels. It was also reported that methyleugenol, an analogue of the phenolic compound eugenol, relaxes the isolated ileum and inhibits contractions induced by stimulation of voltage-dependent and receptor-operated channels (Lima et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Vasorelaxant effects of eugenol on rat thoracic aorta

Damiani

Rossoni

Vassallo

2003

Vascular Pharmacology

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Eugenol is a natural pungent substance and the main component of clove oil, with vasorelaxant action. To elucidate some of the possible mechanisms involved in this action isometric tension was measured in aortic rings from male Wistar rats precontracted with phenylephrine (PHE, 10 À7 M) or KCl (75 mM). Responses to increasing concentrations of eugenol (10 À6 -10 À2 M) were obtained in the presence and absence of endothelium. In the presence of eugenol, dose -response curves to PHE (10 À9 to 10 À4 M) and KCl (5 -125 mM) were displaced downwards. Concentration-dependent relaxation was observed in rings precontracted with PHE (10 À7 M) and KCl (75 mM). The tension increment produced by increasing external calcium concentration (0.25 -3 mM) was also reduced by eugenol (300 mM) treatment. The inhibitory effects of eugenol (300 mM) were compared to those induced by nifedipine (0.01 mM), a selective Ca 2+ channel blocker, producing similar relaxant effects. Two other protocols were performed. After precontraction with PHE (10 À7 M), increasing concentrations of eugenol (10 À6 -10 À2 M) were used before and after N w -nitro-L-arginine (L-NAME, 10 À4 M) and methylene blue (10 À5 M) treatment. Eugenolinduced relaxation was reduced by endothelial damage (rubbing), L-NAME and methylene blue treatments. Results suggested that eugenol produces smooth muscle relaxation resulting from the blockade of both voltage-sensitive and receptor-operated channels that are modulated by endothelial-generated nitric oxide. D

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vasorelaxant effects of eugenol on rat thoracic aorta

Damiani

Rossoni

Vassallo

2003

Vascular Pharmacology

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“…In the scientific literature, too, a great variety of pharmacologi cal and toxicological data on the isolated con stituents of the volatile oil fractions are accu mulating. Eugenol is reported to show anti septic and analgesic properties {Dobbs, 1961; Kay, 1972), local anesthetic activity {Siemoneit et al" 1966), spasmolytic activity (Jurcic and Wagner, 1976), parasympathetic effects (in- O C H 3 crease in salivary gland secretion) and direct peripheral vasodilatation (Sticht and Smith, 1971). It is also shown to inhibit partially the carcinogenic effect of benzopyrene ( Van Duuren and Goldschmidt, 1976).…”

Section: Introductionmentioning

confidence: 99%

Anesthetic, Hypothermic, Myorelaxant and Anticonvulsant Effects of Synthetic Eugenol Derivatives and Natural Analogues

1981

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Nine newly synthesized eugenol derivatives were investigated in rats or mice as to their anesthetic, hypothermic, myorelaxant and anticonvulsant effects. Additional pharmacological activity which appeared during the experiments is described. For comparative purposes, six naturally occurring eugenol analogues were included in the study. The results are further discussed as to possible structure-activity relationships between the test compounds and the four investigated effects.

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“…This plant is known by several of its psychotropic effects in man, among them depression and states of unconsciousness (8,19,20). Animal studies also disclosed that eugenol (E) and several of its synthetic derivatives induce depression, loss of postural reflexes and potentiation of barbi turate sleeping time (10,14,15,17). Furthermore, several of these compounds revealed to be intravenous general anesthetics in humans (5,6,12).…”

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confidence: 99%

Anesthetic Action of Methyleugenol and Other Eugenol Derivatives

Sell¹,

Carlini²

1976

Pharmacology

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A comparative study of four natural eugenol compounds found in the volatile oil fraction of Myristica pagans, namely eugenol (E), methyleugenol (ME), isoeugenol and methylisoeugenol, was carried out in mice. Using a mixture of saline + tween-80 to suspend the compounds and the intraperitoneal route, ME revealed to be the most active and the less toxic in inducing the loss of the righting reflex. ME was further compared with pentobarbital and with the synthetic E derivative, propanidid, using the intraperitoneal route in rats. ME anesthetized the rats more rapidly than pentobarbital; however, the duration of anesthesia was the same for both drugs. Propanidid was not active when injected through the intraperitoneal route. Rats under ME anesthesia could be more easily operated, showed less cyanosis, and recovered better than those under pentobarbital. When injected intravenously in rabbits, ME and propanidid showed equivalent anesthetic effects. Daily intraperitoneal injections of ME in rats and mice for up to 42 days, showed that the drug was not toxic and that the animals became more sensitive to the anesthetic action with repeating the injections. Similarly to pentobarbital, ME induced large amounts of slow wave activity in EEG of rats and did not change the total brain levels of dopamine, norepinephrine, and 5-hydroxytryptamine.

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Eugenol: Some Pharmacologic Observations

Cited by 47 publications

References 3 publications

Vasorelaxant effects of eugenol on rat thoracic aorta

Vasorelaxant effects of eugenol on rat thoracic aorta

Anesthetic, Hypothermic, Myorelaxant and Anticonvulsant Effects of Synthetic Eugenol Derivatives and Natural Analogues

Anesthetic Action of Methyleugenol and Other Eugenol Derivatives

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