Euphorbia tirucalli L.: Review on morphology, medicinal uses, phytochemistry and pharmacological activities

Mali, Prashant; Panchal, Shital S.

doi:10.1016/j.apjtb.2017.06.002

Cited by 31 publications

(17 citation statements)

References 52 publications

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“…Taraxerone has allelopathic and antifungal effect 20 , Morusin has anti-oxidant and anticancer properties 21 , RA VII compound is an antitumor agent 22 , and neoruscogenin is used against chronic venous disorders 23 . Justicidin D exhibits anti-inflammatory properties 24 , Licoricidin is an antimetastatic molecule 25 whereas euphol is used against asthma and cancer along with syphilis, and rheumatism 26 . Schisandrene has anti-oxidant activity 27 , curine is reported as a vasodilator 27 , angoluvarin has antimicrobial activity 28 , baicalin is used to treat cardiovascular diseases, inflammation and hypertension 29 .…”

Section: Discussionmentioning

confidence: 99%

Coronavirus disease 2019 drug discovery through molecular docking

Singh

Flórez

2020

F1000Res

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Background: The dawn of the year 2020 witnessed the spread of the highly infectious and communicable disease coronavirus disease 2019 (COVID-19) globally since it was ﬁrst reported in 2019. Severe acute respiratory syndrome coronavirus-2 is the main causative agent. In total, 3,096,626 cases and 217,896 deaths owing to COVID-19 were reported by 30th April, 2020 by the World Health Organization. This means infection and deaths show an exponential growth globally. In order to tackle this pandemic, it is necessary to ﬁnd possible easily accessible therapeutic agents till an effective vaccine is developed. Methods: In this study, we present the results of molecular docking processes through high throughput virtual screening to analyze drugs recommended for the treatment of COVID-19. Results: Atovaquone, fexofenadine acetate (Allegra), ethamidindole, baicalin, glycyrrhetic acid, justicidin D, euphol, and curine are few of the lead molecules found after docking 129 known antivirals, antimalarial, antiparasitic drugs and 992 natural products. Conclusions: These molecules could act as an effective inhibitory drug against COVID-19.

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Section: Discussionmentioning

confidence: 99%

Coronavirus disease 2019 drug discovery through molecular docking

Singh

Flórez

2020

F1000Res

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“…ex Boiss. like E. lathyris , can be used as an emetic against snakebites [39,51]. A recent review has been published showing that E. tirucalli (whole plant and its parts individually separated) has some records in South America, India, the Middle East, and Africa regarding beneficial effects on leprosy, syphilis, cancer, asthma, and intestinal parasites [51].…”

Section: Traditional Medicine Uses Of Euphorbia Plantsmentioning

confidence: 99%

“…like E. lathyris , can be used as an emetic against snakebites [39,51]. A recent review has been published showing that E. tirucalli (whole plant and its parts individually separated) has some records in South America, India, the Middle East, and Africa regarding beneficial effects on leprosy, syphilis, cancer, asthma, and intestinal parasites [51]. The same research group [52] also published a review where they report the various applications in traditional medicine of E. neriifolia L. Its latex is used as a carminative and expectorant, as well as in the treatment of tumours, abdominal and skin problems, leprosy, asthma, and kidney stones, while the roots are used in the treatment of scorpion stings and snake bites.…”

Section: Traditional Medicine Uses Of Euphorbia Plantsmentioning

confidence: 99%

“…Plants belonging to the genus Euphorbia are also of the great interest in the matter of their antimicrobial activity [51,52,[78][79][80]. In fact, these plants are also widely used in the traditional medicine in the microbial infections [81,82], and some Euphorbia plants are believed to be a promising source of phytochemicals used in the pharmacy and food industries [83].…”

Section: Antibacterial and Antifungal Activity Of Euphorbia Plantsmentioning

confidence: 99%

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Euphorbia-Derived Natural Products with Potential for Use in Health Maintenance

et al. 2019

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Euphorbia genus (Euphorbiaceae family), which is the third largest genus of angiosperm plants comprising ca. 2000 recognized species, is used all over the world in traditional medicine, especially in the traditional Chinese medicine. Members of this taxa are promptly recognizable by their specialized inflorescences and latex. In this review, an overview of Euphorbia-derived natural products such as essential oils, extracts, and pure compounds, active in a broad range of biological activities, and with potential usages in health maintenance, is described. The chemical composition of essential oils from Euphorbia species revealed the presence of more than 80 phytochemicals, mainly oxygenated sesquiterpenes and sesquiterpenes hydrocarbons, while Euphorbia extracts contain secondary metabolites such as sesquiterpenes, diterpenes, sterols, flavonoids, and other polyphenols. The extracts and secondary metabolites from Euphorbia plants may act as active principles of medicines for the treatment of many human ailments, mainly inflammation, cancer, and microbial infections. Besides, Euphorbia-derived products have great potential as a source of bioactive extracts and pure compounds, which can be used to promote longevity with more health.

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“…It also has various medicinal uses such as in cases of cough, asthma, warts and rheumatism. The sap of the Euphorbia tirucalli was proved to be irritating to the human eyes and may result in kerato-conjunctivitis [36].…”

Section: Euphorbia Tirucalli Latexmentioning

confidence: 99%

Staphyloxanthin as a Potential Novel Target for Deciphering Promising Anti-Staphylococcus aureus Agents

et al. 2022

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Staphylococcus aureus is a fatal Gram-positive pathogen threatening numerous cases of hospital-admitted patients worldwide. The emerging resistance of the pathogen to several antimicrobial agents has pressurized research to propose new strategies for combating antimicrobial resistance. Novel strategies include targeting the virulence factors of S. aureus. One of the most prominent virulence factors of S. aureus is its eponymous antioxidant pigment staphyloxanthin (STX), which is an auspicious target for anti-virulence therapy. This review provides an updated outline on STX and multiple strategies to attenuate this virulence factor. The approaches discussed in this article focus on bioprospective and chemically synthesized inhibitors of STX, inter-species communication and genetic manipulation. Various inhibitor molecules were found to exhibit appreciable inhibitory effect against STX and hence would be able to serve as potential anti-virulence agents for clinical use.

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Euphorbia tirucalli L.: Review on morphology, medicinal uses, phytochemistry and pharmacological activities

Cited by 31 publications

References 52 publications

Coronavirus disease 2019 drug discovery through molecular docking

Coronavirus disease 2019 drug discovery through molecular docking

Euphorbia-Derived Natural Products with Potential for Use in Health Maintenance

Staphyloxanthin as a Potential Novel Target for Deciphering Promising Anti-Staphylococcus aureus Agents

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