Evaluating Insect Odorant Receptor Display Formats for Biosensing Using Graphene Field Effect Transistors

Murugathas, Thanihaichelvan; Hamiaux, Cyril; Colbert, Damon; Kralicek, Andrew V.; Plank, Natalie O. V.; Carraher, Colm

doi:10.1021/acsaelm.0c00677

Cited by 26 publications

(16 citation statements)

References 45 publications

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“…Positive threshold voltage also con rms that the majority change carrier of the Cs 2 AgBiBr 6 FET is holes when the gate bias is not applied. 24,25,33,34 The negative shift in threshold voltage with increasing channel length is a signi cance of reduced effective hole concentration with increasing channel length which is opposite to the observations by Matsushima et al on (C 6 H 5 C 2 H 4 NH 3 ) 2 SnI 4 perovskite FETs. 32 This also shows that the electron and hole transport can be hindered by the grain boundaries during the transport.…”

Section: Discussioncontrasting

confidence: 65%

Air Processed Cs2AgBiBr6 Lead-free Double Perovskite High-mobility Thin Film Field-effect Transistors

Abiram

Gourji

Pitchaiya

et al. 2021

Preprint

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This study focuses on the fabrication and characterization of Cs2AgBiBr6 double perovskite thin film for field-effect transistor (FET) applications. The Cs2AgBiBr6 thin films were fabricated using a solution process technique and the observed XRD patterns demonstrate no diffraction peaks of secondary phases, which confirms the phase-pure crystalline nature. The average grain sizes of the spin-deposited film were also calculated by analysing the statistics of grain size in SEM image and was found to be around 412 (±44) nm the larger grain size was also confirmed by the XRD measurements. FETs with different channel lengths of Cs2AgBiBr6 thin films were fabricated on an electrode deposited heavily doped p-type Si substrate with a 300 nm thermally grown SiO2 dielectric under ideal conditions in air processing under ambient pressure and temperature. The Cs2AgBiBr6 FETs showed a p-type nature with a positive threshold voltage. The on current, threshold voltage and hole-mobility of the FETs decreased with increasing channel length. A high average hole mobility of 0.29 cm2s-1V-1 was obtained for the FETs with a channel length of 30 µm, and the hole mobility was reduced by an order of magnitude (0.012 cm2s-1V-1) when the channel length was doubled. The on current and hole-mobility of Cs2AgBiBr6 FETs followed a power fit, which confirmed the dominance of channel length in electrostatic gating in Cs2AgBiBr6 FETs. A very high-hole mobility observed in or FET that could be attributed to the much larger grain size of Cs2AgBiBr6 film made in this work.

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Section: Discussioncontrasting

confidence: 65%

Air Processed Cs2AgBiBr6 Lead-free Double Perovskite High-mobility Thin Film Field-effect Transistors

Abiram

Gourji

Pitchaiya

et al. 2021

Preprint

Self Cite

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“…Among the existing diagnostic methods, the FET based biosensor delivers several obvious advantages for virus detection, including high selectivity through modified with target receptors, high sensitivity with label free process, real time electrical signal in-situ amplification and recording, cost-effective mass production with microelectronics manufacturing processes, and small size for portable point-of-care test [ [26] , [27] , [28] ]. Graphene, a one atom-thick large area 2D carbon material, has excellent chemical and physical properties in biosensing, such as good biocompatibility, strong interaction with biomolecules through π-π stacking and high intrinsic carrier mobility [ [29] , [30] , [31] ]. Many efforts have recently been devoted to the Gr-FET biosensors for highly sensitive and label-free cancer and virus protein detection [ 25 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Graphene oxide-graphene Van der Waals heterostructure transistor biosensor for SARS-CoV-2 protein detection

Gao

Chu

Han

et al. 2022

Talanta

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The current outbreaking of the coronavirus SARS-CoV-2 pandemic threatens global health and has caused serious concern. Currently there is no specific drug against SARS-CoV-2, therefore, a fast and accurate diagnosis method is an urgent need for the diagnosis, timely treatment and infection control of COVID-19 pandemic. In this work, we developed a field effect transistor (FET) biosensor based on graphene oxide-graphene (GO/Gr) van der Waals heterostructure for selective and ultrasensitive SARS-CoV-2 proteins detection. The GO/Gr van der Waals heterostructure was in-situ formed in the microfluidic channel through π-π stacking. The developed biosensor is capable of SARS-CoV-2 proteins detection within 20 min in the large dynamic range from 10 fg/mL to 100 pg/mL with the limit of detection of as low as ∼8 fg/mL, which shows ∼3 × sensitivity enhancement compared with Gr-FET biosensor. The performance enhancement mechanism was studied based on the transistor-based biosensing theory and experimental results, which is mainly attributed to the enhanced SARS-CoV-2 capture antibody immobilization density due to the introduction of the GO layer on the graphene surface. The spiked SARS-CoV-2 protein samples in throat swab buffer solution were tested to confirm the practical application of the biosensor for SARS-CoV-2 proteins detection. The results indicated that the developed GO/Gr van der Waals heterostructure FET biosensor has strong selectivity and high sensitivity, providing a potential method for SARS-CoV-2 fast and accurate detection.

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“…Moreover, despite some pioneering bioengineering efforts (e.g. [ 300 ]) integrating biological sensors into sensitive and robust optical- or electrical-based recording devices remains a huge technical challenge.…”

Section: Applicationsmentioning

confidence: 99%

Drosophila olfaction: past, present and future

Benton

2022

Proc. R. Soc. B.

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Among the many wonders of nature, the sense of smell of the fly Drosophila melanogaster might seem, at first glance, of esoteric interest. Nevertheless, for over a century, the ‘nose’ of this insect has been an extraordinary system to explore questions in animal behaviour, ecology and evolution, neuroscience, physiology and molecular genetics. The insights gained are relevant for our understanding of the sensory biology of vertebrates, including humans, and other insect species, encompassing those detrimental to human health. Here, I present an overview of our current knowledge of D. melanogaster olfaction, from molecules to behaviours, with an emphasis on the historical motivations of studies and illustration of how technical innovations have enabled advances. I also highlight some of the pressing and long-term questions.

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Evaluating Insect Odorant Receptor Display Formats for Biosensing Using Graphene Field Effect Transistors

Cited by 26 publications

References 45 publications

Air Processed Cs2AgBiBr6 Lead-free Double Perovskite High-mobility Thin Film Field-effect Transistors

Air Processed Cs2AgBiBr6 Lead-free Double Perovskite High-mobility Thin Film Field-effect Transistors

Graphene oxide-graphene Van der Waals heterostructure transistor biosensor for SARS-CoV-2 protein detection

Drosophila olfaction: past, present and future

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