Evaluation in vivo of anti-inflammatory and analgesic properties of Matricaria pubescens alkaloids

Metrouh-Amir, Hassiba; Amir, Nadir

doi:10.1016/j.sajb.2018.03.008

Cited by 9 publications

(5 citation statements)

References 22 publications

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“…The genus Crinum have also been documented to present huge number alkaloids [27,28]. While alkaloids are well known for their ability to inhibit the perception of pain and to be an anti-inflammatory [29]. The presence of these chemical compounds in the extract could be responsible for anti-inflammatory activity.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Anti-inflammatory Activity of Crinum scillifolium Extracts in Wistar Rats

Donald¹,

Genevieve²,

Etienne³

et al. 2018

ijbb

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Aim of study: Inflammation was associated with many diseases in humans. Crinum species have a considerable medicinal reputation as potent folkloric remedies. The main objective of the study was to evaluate the anti-inflammatory activity of aqueous and hydroethanolic extracts of Crinum scillifolium bulbs in in vivo models. Materials and methods: The anti-inflammatory effect of Crinum scillifolium extracts was also evaluated in carrageenan-induced paw edema models and C-reactive protein (CRP) levels was measured. Two doses 100 and 200 mg/kg body weight for each extract, were tested. The results obtained were compared with those of the standard drug (Diclofenac at 25 mg/kg body weight) and those of the control (normal saline). Results: The results showed a highly significant decrease in the edema size (p < 0.01) and significant decrease in CRP values (p < 0.01) compared to control group when the animals were treated with diclofenac at 25 mg/kg, and 200 mg/kg of aqueous and hydroethanolic extracts. Conclusion: The study suggests that the extracts possess enough potential to reduce inflammation on rat model and directs the importance of further research and development of novel anti-inflammatory agents.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Anti-inflammatory Activity of Crinum scillifolium Extracts in Wistar Rats

Donald¹,

Genevieve²,

Etienne³

et al. 2018

ijbb

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“…It is an endemic North African species. [12] In the southeast of Algeria, this plant is used in traditional medicine to treat many diseases, such as rheumatic and muscular pains, scorpion stings, dysmenorrhea, dehydration, coughs, allergies, ocular affections, and toothache. The aerial part of this plant is prepared as an infusion or powdered in food and used internally.…”

Section: Introductionmentioning

confidence: 99%

“…M. pubescens is a plant of the Asteraceae family, known as the chamomile of the Sahara. It is an endemic North African species [12] . In the southeast of Algeria, this plant is used in traditional medicine to treat many diseases, such as rheumatic and muscular pains, scorpion stings, dysmenorrhea, dehydration, coughs, allergies, ocular affections, and toothache.…”

Section: Introductionmentioning

confidence: 99%

Potential Hepatoprotective Effect of Matricaria Pubescens on High‐Fat Diet‐Induced Non‐Alcoholic Fatty Liver Disease in Rats

Chenna,

Khelef,

Halimi

et al. 2024

Chemistry & Biodiversity

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This study aimed to identify the phytochemical compounds of Matricaria pubescens by LC–MS/MS and evaluate the potential protective effect of its supplementation in high‐fat diet (HFD)‐induced non‐alcoholic fatty liver disease (NAFLD) in adult rats through modulation of oxidative stress and histopathological changes. Twenty‐four male rats were randomly divided into four groups. The first group served as control and received the standard diet. The second group (HFD) received a high‐fat diet only (30 % of sheep fat). The third group‘s (control+MP) animals received a standard diet supplemented with 5 % M. pubescens (w/w). The fourth group (HFD+MP) received a high‐fat diet supplemented with 5 % M. pubescens for 16 weeks. LC–MS/MS analysis showed that M. pubescens contains many phytochemical compounds. It was observed that the ethanolic extract of M. pubescens has a higher phenolic content than the aqueous extract. The supplementation of M. pubescens (5 % w/w) to HFD rats decreased significantly (p<0.01) body weight, liver and epididymal adipose tissue relative weights, glycemia, triglycerides (TG), insulin resistance, liver markers, TNF‐α, malondialdehyde (MDA), protein carbonyl (PCO), advanced oxidation protein products (AOPP) level, and increased reduced glutathione (GSH) level, glutathione peroxidase (GPx), glutathione‐S‐transferase (GST), superoxide dismutase (SOD), and catalase activities as well as ameliorated histological alterations through the reduction hepatic lipid deposition and adipocytes hypertrophy compared to the HFD group. We conclude that M. pubescens powder may be effective for correcting hyperglycemia, hypertriglyceridemia, insulin resistance, and liver markers while decreasing inflammation and oxidative stress in the liver of high‐fat diet‐fed rats.

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“…Alkaloids the main active ingredients of E. tubulosa Dunn. are increasingly used in clinical treatment [3] with anti-tumor [4], antiviral and antibacterial [5], anti-inflammatory and analgesic [6], cardiovascular effect [7], insecticidal [8]. Matrine and oxymatrine are recently proved to have anti-cancer potentials, such as inhibiting cancer cell proliferation, inducing cell differentiation [9].…”

Section: Introductionmentioning

confidence: 99%

Systematic Separation and Purification of Alkaloids from Euchresta tubulosa Dunn. by Various Chromatographic Methods

2019

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High-speed countercurrent chromatography (HSCCC) and silica gel column chromatography were used to separate and purify alkaloids from Chinese herbal medicine Euchresta tubulosa Dunn. The purpose of this study is to provide a system mode for rapid separation of alkaloids from natural products. In the experiment, the eluent of silica gel column chromatography was screened by thin layer chromatography (TLC) to obtain four components with different polarity. Then, the two-phase solvent systems of different components were selected and purified by HSCCC. Four alkaloids with relatively high content were obtained by this mode successfully, including matrine (28 mg), oxymatrine (32 mg), N-formyl cytisine (24 mg), and cytisine (58 mg). The purity was higher than 91% by high performance liquid chromatography–ultraviolet (HPLC-UV) and their chemical structures were identified by nuclear magnetic resonance (NMR) and electron ionization mass spectrometry (EI-MS). The results showed that the combination of HSCCC and silica gel column chromatography could make alkaloids from natural products separate systematically.

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Evaluation in vivo of anti-inflammatory and analgesic properties of Matricaria pubescens alkaloids

Cited by 9 publications

References 22 publications

Evaluation of Anti-inflammatory Activity of Crinum scillifolium Extracts in Wistar Rats

Evaluation of Anti-inflammatory Activity of Crinum scillifolium Extracts in Wistar Rats

Potential Hepatoprotective Effect of Matricaria Pubescens on High‐Fat Diet‐Induced Non‐Alcoholic Fatty Liver Disease in Rats

Systematic Separation and Purification of Alkaloids from Euchresta tubulosa Dunn. by Various Chromatographic Methods

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